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Personal profile

Research interests

The impact of Noncoding RNAs (ncRNAs) such as microRNAs and, more recently, long ncRNAs (LncRNAs) onto eukaryotic gene regulation has just started to be understood. The research Group of Jan-Wilhelm Kornfeld lab would like to take part in this 'Noncoding RNA revolution' by identifying novel ncRNAs and elucidating their role in homeostatic circuits regulating energy homeostasis in health and disease. We apply state-of-the art techniques such as next-generation sequencing, the generation of transgenic mouse models and in vivo anti-ncRNA approaches to ultimately better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.

Research areas

Noncoding RNAs, Energy Metabolism, Obesity, Type 2 Diabetes, Adipose tissue, Epigenetics

Research areas

  • Bioinformatics
  • Antisense and siRNA
  • Obesity
  • Fat cell development and function
  • Cirrhosis

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Research Output

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Pradas-Juni, M., Hansmeier, N. R., Link, J. C., Schmidt, E., Larsen, B. D., Klemm, P., Meola, N., Topel, H., Loureiro, R., Dhaouadi, I., Kiefer, C. A., Schwarzer, R., Khani, S., Oliverio, M., Awazawa, M., Frommolt, P., Heeren, J., Scheja, L., Heine, M., Dieterich, C. & 15 others, Büning, H., Yang, L., Cao, H., Jesus, D. F. D., Kulkarni, R. N., Zevnik, B., Tröder, S. E., Knippschild, U., Edwards, P. A., Lee, R. G., Yamamoto, M., Ulitsky, I., Fernandez-Rebollo, E., Vallim, T. Q. D. A. & Kornfeld, J-W., 31. Jan 2020, In : Nature Communications. 11, 1, p. 644

Research output: Contribution to journalJournal articleResearchpeer-review

  • Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

    Fernandez-Rebollo, E., Franzen, J., Goetzke, R., Hollmann, J., Ostrowska, A., Oliverio, M., Sieben, T., Rath, B., Kornfeld, J-W. & Wagner, W., 11. Feb 2020, In : Stem Cell Reports. 14, 2, p. 201-209

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

    Hansmeier, N. R., Widdershooven, P. J. M., Khani, S. & Kornfeld, J-W., 23. Jan 2019, In : Non-Coding R N A. 5, 1, p. 1-12 12.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 156 Downloads (Pure)

    s ·nr: a visual analytics framework for contextual analyses of private and public RNA-seq data

    Klemm, P., Frommolt, P. & Kornfeld, J. W., 24. Jan 2019, In : BMC Genomics. 20, 12 p., 85.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 131 Downloads (Pure)

    LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

    Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N. R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P. & 5 others, Ørom, U. A., Heeren, J., Blüher, M., Bilban, M. & Kornfeld, J. W., 6. Sep 2018, In : Nature Communications. 9, 1, 16 p., 3622.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 128 Downloads (Pure)

    Activities

    Conference talk 'Long noncoding RNAs in Energy Homeostasis and Metabolic Disease'

    Jan-Wilhelm Kornfeld (Guest lecturer)
    11. Dec 2019

    Activity: Talks and presentationsTalks and presentations in private or public companies

    Workshop 'Does diabetes start from before conception? – An transgenerational perspective on Metabolic Disease'

    Jan-Wilhelm Kornfeld (Guest lecturer), Joo Hyun Park (Guest lecturer)
    27. Nov 2019

    Activity: Talks and presentationsGuest lectures, external teaching and course activities at other universities

    Conference talk 'Long noncoding RNAs in Energy Homeostasis and Metabolic Diseases'

    Jan-Wilhelm Kornfeld (Lecturer)
    12. Sep 2019

    Activity: Talks and presentationsConference presentations

    Conference talk 'Plasticity of BAT signaling responses during cold exposure and metabolic disease'

    Jan-Wilhelm Kornfeld (Lecturer)
    3. Jun 2019

    Activity: Talks and presentationsTalks and presentations in private or public companies

    ADIPOSIGN Opening Sympoisum

    Susanne Mandrup (Organizer), Marianne Holmer (Panel member), Jakob Møller-Jensen (Panel member), Jan-Wilhelm Kornfeld (Panel member), Zachary Gerhart-Hines (Panel member), M. Madan Babu (Panel member), Matthias Blüher (Panel member), Ruth J F Loos (Panel member), Martin Klingenspor (Panel member), Christian Wolfrum (Panel member)
    27. May 2019

    Activity: Attending an eventOrganisation or participation in workshops, courses or seminars

    Projects

    Press / Media

    Kan spøgelses-gen hæmme diabetes?

    Jan-Wilhelm Kornfeld

    05/02/2020

    1 Media contribution

    Press/Media: Press / Media

    PRM / Ny forskning: Spøgelses-gener holder diabetes i skak

    Jan-Wilhelm Kornfeld

    03/02/2020

    1 Media contribution

    Press/Media: Press / Media

    PRM / Ny forskning: Spøgelses-gener holder diabetes i skak

    Jan-Wilhelm Kornfeld

    03/02/2020

    1 Media contribution

    Press/Media: Press / Media

    Spøgelses-gen har betydning for stofskiftefunktionen

    Jan-Wilhelm Kornfeld

    03/02/2020

    1 Media contribution

    Press/Media: Press / Media

    PRM / Ny forskning: Spøgelses-gener holder diabetes i skak

    Jan-Wilhelm Kornfeld

    03/02/2020

    1 Media contribution

    Press/Media: Press / Media

    Teaching & Supervision

    NAT501 - First year project - Responsible supervisor

    Jan-Wilhelm Kornfeld & Christoph Andreas Kiefer

    01/01/2018 → …

    Course: Teaching and supervisionTeaching

    BMB508 - Advanced Molecular Biology

    Jan-Wilhelm Kornfeld

    01/01/2018 → …

    Course: Teaching and supervisionTeaching

    BMB822 - Modern Developments and Technologies in Molecular Cell Biology

    Jan-Wilhelm Kornfeld &

    01/01/2018 → …

    Course: Teaching and supervisionTeaching