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Personal profile

Research interests

The impact of Noncoding RNAs (ncRNAs) such as microRNAs and, more recently, long ncRNAs (LncRNAs) onto eukaryotic gene regulation has just started to be understood. The research Group of Jan-Wilhelm Kornfeld lab would like to take part in this 'Noncoding RNA revolution' by identifying novel ncRNAs and elucidating their role in homeostatic circuits regulating energy homeostasis in health and disease. We apply state-of-the art techniques such as next-generation sequencing, the generation of transgenic mouse models and in vivo anti-ncRNA approaches to ultimately better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.

Research areas

Noncoding RNAs, Energy Metabolism, Obesity, Type 2 Diabetes, Adipose tissue, Epigenetics

Research areas

  • Bioinformatics
  • Antisense and siRNA
  • Obesity
  • Fat cell development and function
  • Cirrhosis

Fingerprint Dive into the research topics where Jan-Wilhelm Kornfeld is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Metabolism Chemical Compounds
Gene expression Chemical Compounds
Somatotropin Receptors Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2020

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Pradas-Juni, M., Hansmeier, N. R., Link, J. C., Schmidt, E., Larsen, B. D., Klemm, P., Meola, N., Topel, H., Loureiro, R., Dhaouadi, I., Kiefer, C. A., Schwarzer, R., Khani, S., Oliverio, M., Awazawa, M., Frommolt, P., Heeren, J., Scheja, L., Heine, M., Dieterich, C. & 15 others, Büning, H., Yang, L., Cao, H., Jesus, D. F. D., Kulkarni, R. N., Zevnik, B., Tröder, S. E., Knippschild, U., Edwards, P. A., Lee, R. G., Yamamoto, M., Ulitsky, I., Fernandez-Rebollo, E., Vallim, T. Q. D. A. & Kornfeld, J-W., 31. Jan 2020, In : Nature Communications. 11, 1, p. 644

Research output: Contribution to journalJournal articleResearchpeer-review

obesity
Long Noncoding RNA
nutrients
metabolism
Metabolism

Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

Fernandez-Rebollo, E., Franzen, J., Goetzke, R., Hollmann, J., Ostrowska, A., Oliverio, M., Sieben, T., Rath, B., Kornfeld, J-W. & Wagner, W., 11. Feb 2020, In : Stem Cell Reports. 14, 2, p. 201-209

Research output: Contribution to journalJournal articleResearchpeer-review

Galactosidases
Orotic Acid
Ribonucleotides
Niacinamide
Cell Aging
127 Downloads (Pure)

Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

Hansmeier, N. R., Widdershooven, P. J. M., Khani, S. & Kornfeld, J-W., 23. Jan 2019, In : Non-Coding R N A. 5, 1, p. 1-12 12.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Long Noncoding RNA
Gene Targeting
Guide RNA
Gene Knockout Techniques
112 Downloads (Pure)

s ·nr: a visual analytics framework for contextual analyses of private and public RNA-seq data

Klemm, P., Frommolt, P. & Kornfeld, J. W., 24. Jan 2019, In : BMC Genomics. 20, 12 p., 85.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Research Personnel
RNA
Transcriptome
Datasets
102 Downloads (Pure)

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N. R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P. & 5 others, Ørom, U. A., Heeren, J., Blüher, M., Bilban, M. & Kornfeld, J. W., 6. Sep 2018, In : Nature Communications. 9, 1, 16 p., 3622.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
obesity
adipose tissues
fats
genes
Genes

Activities 2018 2019

Conference talk 'Long noncoding RNAs in Energy Homeostasis and Metabolic Disease'

Jan-Wilhelm Kornfeld (Guest lecturer)
11. Dec 2019

Activity: Talks and presentationsTalks and presentations in private or public companies

Workshop 'Does diabetes start from before conception? – An transgenerational perspective on Metabolic Disease'

Jan-Wilhelm Kornfeld (Guest lecturer), Joo Hyun Park (Guest lecturer)
27. Nov 2019

Activity: Talks and presentationsGuest lectures, external teaching and course activities at other universities

Conference talk 'Long noncoding RNAs in Energy Homeostasis and Metabolic Diseases'

Jan-Wilhelm Kornfeld (Lecturer)
12. Sep 2019

Activity: Talks and presentationsConference presentations

Conference talk 'Plasticity of BAT signaling responses during cold exposure and metabolic disease'

Jan-Wilhelm Kornfeld (Lecturer)
3. Jun 2019

Activity: Talks and presentationsTalks and presentations in private or public companies

ADIPOSIGN Opening Sympoisum

Susanne Mandrup (Organizer), Marianne Holmer (Panel member), Jakob Møller-Jensen (Panel member), Jan-Wilhelm Kornfeld (Panel member), Zachary Gerhart-Hines (Panel member), M. Madan Babu (Panel member), Matthias Blüher (Panel member), Ruth J F Loos (Panel member), Martin Klingenspor (Panel member), Christian Wolfrum (Panel member)
27. May 2019

Activity: Attending an eventOrganisation or participation in workshops, courses or seminars

Projects 2016 2024

Press / Media

Kan spøgelses-gen hæmme diabetes?

Jan-Wilhelm Kornfeld

05/02/2020

1 Media contribution

Press/Media: Press / Media

Spøgelses-gen har betydning for stofskiftefunktionen

Jan-Wilhelm Kornfeld

03/02/2020

1 Media contribution

Press/Media: Press / Media

Ny forskning: Spøgelses-gener holder diabetes i skak

Jan-Wilhelm Kornfeld

03/02/2020

1 Media contribution

Press/Media: Press / Media

PRM / Ny forskning: Spøgelses-gener holder diabetes i skak

Jan-Wilhelm Kornfeld

03/02/2020

1 Media contribution

Press/Media: Press / Media

PRM / Ny forskning: Spøgelses-gener holder diabetes i skak

Jan-Wilhelm Kornfeld

03/02/2020

1 Media contribution

Press/Media: Press / Media