• Campusvej 55

    5230 Odense M

    Denmark

19992020

Research output per year

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Research Output

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Journal article
2020

Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells

Barrio-Hernandez, I., Jafari, A., Rigbolt, K. T. G., Hallenborg, P., Sanchez-Quiles, V., Skovrind, I., Akimov, V., Kratchmarova, I., Dengjel, J., Kassem, M. & Blagoev, B., Jan 2020, In : Genome Research. 30, 1, p. 127-137 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
16 Downloads (Pure)

SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Muñoa-Hoyos, I., Gianzo, M., Rodriguez, J. A., Ganzabal, T., Blagoev, B., Kratchmarova, I. & Subiran, N., 27. Mar 2020, In : Scientific Reports. 10, 9 p., 5625.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
16 Downloads (Pure)
2019

NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells

Marquez, J., Kratchmarova, I., Akimov, V., Unda, F., Ibarretxe, G., Clerigué, A. S., Osinalde, N. & Badiola, I., 1. Feb 2019, In : Oncology Reports. 41, 2, p. 742-752

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
123 Downloads (Pure)

Phosphoproteomic and functional analyses reveal sperm-specific protein changes downstream of kappa opioid receptor in human spermatozoa

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Candenas, L., Pinto, F. M., Muñoa-Hoyos, I., Gianzo, M., Matorras, R., Irazusta, J., Blagoev, B., Subiran, N. & Kratchmarova, I., 15. Mar 2019, In : Molecular and Cellular Proteomics. 18, Suppl 1, p. S118-S131

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
198 Downloads (Pure)
2018

Data on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation

Sanchez-Quiles, V., Osinalde, N., Akimov, V., Kratchmarova, I. & Blagoev, B., 1. Jun 2018, In : Data in Brief. 18, p. 1856-1863

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
153 Downloads (Pure)

StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites

Akimov, V., Olsen, L. C. B., Hansen, S. V. F., Barrio-Hernandez, I., Puglia, M., Jensen, S. S., Solov'yov, I. A., Kratchmarova, I. & Blagoev, B., 2018, In : Journal of Proteome Research. 17, 1, p. 296-304

Research output: Contribution to journalJournal articleResearchpeer-review

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Akimov, V., Barrio-Hernandez, I., Hansen, S. V. F., Hallenborg, P., Pedersen, A-K., Bekker-Jensen, D. B., Puglia, M., Christensen, S. D. K., Vanselow, J. T., Nielsen, M. M., Kratchmarova, I., Kelstrup, C. D., Olsen, J. V. & Blagoev, B., 2018, In : Nature Structural and Molecular Biology. 25, 7, p. 631-640

Research output: Contribution to journalJournal articleResearchpeer-review

2017

Characterization of receptor-associated protein complex assembly in interleukin (IL)-2- and IL-15-activated T-cell lines

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Aloria, K., Arizmendi, J. M., Blagoev, B. & Kratchmarova, I., 6. Jan 2017, In : Journal of Proteome Research. 16, 1, p. 106-121

Research output: Contribution to journalJournal articleResearchpeer-review

Cylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor

Sanchez-Quiles, V., Akimov, V., Osinalde, N., Francavilla, C., Puglia, M., Barrio-Hernandez, I., Kratchmarova, I., Olsen, J. V. & Blagoev, B., 2017, In : Molecular and Cellular Proteomics. 16, 8, p. 1433-1446 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
137 Downloads (Pure)

Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes

Osinalde, N., Sánchez-Quiles, V., Blagoev, B. & Kratchmarova, I., 2017, In : Data in Brief. 11, p. 499-506

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
143 Downloads (Pure)

Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates

Mead, A. F., Osinalde, N., Ørtenblad, N., Nielsen, J., Brewer, J., Vellema, M., Adam, I., Scharff, C., Song, Y., Frandsen, U., Blagoev, B., Kratchmarova, I. & Elemans, C. P., 2017, In : eLife. 6, 20 p., e29425.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
234 Downloads (Pure)
2016

Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes

Osinalde, N., Sánchez-Quiles, V., Blagoev, B. & Kratchmarova, I., 2016, In : Scientific Reports. 6, p. 23530 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
147 Downloads (Pure)

Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes

Osinalde, N., Mitxelena, J., Sánchez-Quiles, V., Akimov, V., Aloria, K., Arizmendi, J. M., Zubiaga, A. M., Blagoev, B. & Kratchmarova, I., Jun 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 2076-92 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
197 Downloads (Pure)
2015

Cellular Proteome Dynamics during Differentiation of Human Primary Myoblasts

Le Bihan, M-C., Barrio, I., Mortensen, T. P., Henningsen, J., Jensen, S. S., Bigot, A., Blagoev, B., Butler-Browne, G. & Kratchmarova, I., 7. Aug 2015, In : Journal of Proteome Research. 14, 8, p. 3348-3361

Research output: Contribution to journalJournal articleResearchpeer-review

SILAC-based quantification of changes in protein tyrosine phosphorylation induced by Interleukin-2 (IL-2) and IL-15 in T-lymphocytes

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Blagoev, B. & Kratchmarova, I., Dec 2015, In : Data in Brief. 5, p. 53-58

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
148 Downloads (Pure)

Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Guerra, B., Blagoev, B. & Kratchmarova, I., 2015, In : Proteomics. 15, 2-3, p. 520-31

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Analysis of Secreted Proteins Using SILAC

Henningsen, J., Blagoev, B. & Kratchmarova, I., 2014, In : Methods in Molecular Biology. 1188, p. 313-26 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

StUbEx: Stable Tagged Ubiquitin Exchange System for the Global Investigation of Cellular Ubiquitination

Akimov, V., Henningsen, J., Hallenborg, P., Rigbolt, K. T. G., Jensen, S. S., Nielsen, M. M., Kratchmarova, I. & Blagoev, B., 2014, In : Journal of Proteome Research. 13, 9, p. 4192-4204

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Temporal Profiling and Pulsed SILAC Labeling Identify Novel Secreted Proteins during ex vivo Osteoblast Differentiation of Human Stromal Stem Cells

Kristensen, L. P., Chen, L., Nielsen, M. O., Qanie, D. W., Kratchmarova, I., Kassem, M. & Andersen, J. S., 2012, In : Molecular and Cellular Proteomics. 11, 10, p. 989-1007 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells

Andersen, D. C., Kortesidis, A., Zannettino, A. C. W., Kratchmarova, I., Chen, L., Jensen, O. N., Teisner, B., Gronthos, S., Jensen, C. H. & Kassem, M., 2011, In : Molecules and Cells. 32, 2, p. 133-142 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics

Osinalde, N., Moss, H., Arrizabalaga, O., Omaetxebarria, M. J., Blagoev, B., Zubiaga, A. M., Fullaondo, A., Arizmendi, J. M. & Kratchmarova, I., 2011, In : Journal of Proteomics. 75, 1, p. 177-91 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Quantitative analysis of the secretion of the MCP family of chemokines by muscle cells

Henningsen, J., Pedersen, B. K. & Kratchmarova, I., 2011, In : Molecular BioSystems. 7, 2, p. 311-21 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation

Rigbolt, K. T. G., Prokhorova, T. A., Akimov, V., Henningsen, J., Johansen, P. T., Kratchmarova, I., Kassem, M., Mann, M., Olsen, J. V. & Blagoev, B., 2011, In : Science Signaling. 4, 164, p. rs3

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Dynamics of the Skeletal Muscle Secretome during Myoblast Differentiation

Henningsen, J., Rigbolt, K. T. G., Blagoev, B., Pedersen, B. K. & Kratchmarova, I., 1. Nov 2010, In : Molecular and Cellular Proteomics. 9, 11, p. 2482-96 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mapping Protein-Protein Interactions by Quantitative Proteomics

Dengjel, J., Kratchmarova, I. & Blagoev, B., 2010, In : Methods in Molecular Biology. 658, p. 267-278 12 p.

Research output: Contribution to journalJournal articleResearch

Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks

Hammond, D. E., Hyde, R., Kratchmarova, I., Beynon, R. J., Blagoev, B. & Clague, M. J., 7. May 2010, In : Journal of Proteome Research. 9, 5, p. 2734-42 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6

Lissanu Deribe, Y., Wild, P., Chandrashaker, A., Curak, J., Schmidt, M. H. H., Kalaidzidis, Y., Milutinovic, N., Kratchmarova, I., Buerkle, L., Fetchko, M. J., Schmidt, P., Kittanakom, S., Brown, K. R., Jurisica, I., Blagoev, B., Zerial, M., Stagljar, I. & Dikic, I., 1. Jan 2009, In : Science Signaling. 2, 102, p. ra84

Research output: Contribution to journalJournal articleResearchpeer-review

Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells

Prokhorova, T. A., Rigbolt, K. T. G., Johansen, P. T., Henningsen, J., Kratchmarova, I., Kassem, M. & Blagoev, B., 1. May 2009, In : Molecular and Cellular Proteomics. 8, 5, p. 959-70 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2008

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

Krüger, M., Kratchmarova, I., Blagoev, B., Tseng, Y-H., Kahn, C. R. & Mann, M., 2008, In : Proceedings of the National Academy of Science of the United States of America. 105, 7, p. 2451-2456 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2006

PPAR (gamma) recuits the P-TEFb complex to activate transcription and promote adipogenesis

Iankova, I., Annicotte, J-S., Petersen, R. K., Chavey, C., Hansen, J. B., Kratchmarova, I., Sarruf, D., Benkirane, M., Kristiansen, K. & Fajas, L., 2006, In : Molecular Endocrinology. 20, p. 1494-1505

Research output: Contribution to journalJournal articleResearchpeer-review

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hacker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Hacker, G., Mann, M. & Karin, M., 2006, In : Nature. 439, 7073, p. 204-207

Research output: Contribution to journalJournal articleResearchpeer-review

2005

Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation

Kratchmarova, I., Blagoev, B., Haack-Sorensen, M., Kassem, M. & Mann, M., 2005, In : Science. 308, 5727, p. 1472-1477

Research output: Contribution to journalJournal articleResearchpeer-review

2004

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.

Ibarrola, N., Kratchmarova, I., Nakajima, D., Schiemann, W. P., Moustakas, A., Pandey, A. & Mann, M., 2004, In : BMC Cell Biology. 5

Research output: Contribution to journalJournal articleResearchpeer-review

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.

Blagoev, B., Ong, S. E., Kratchmarova, I. & Mann, M., 2004, In : Nature Biotechnology. 22, p. 1139-1145

Research output: Contribution to journalJournal articleResearchpeer-review

2003

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

Blagoev, B., Kratchmarova, I., Ong, S. E., Nielsen, M., Foster, L. J. & Mann, M., 2003, In : Nature Biotechnology. 21(3), p. 315-18

Research output: Contribution to journalJournal articleResearchpeer-review

Properties of 13C-substituted arginine in stable isotope labeling by amino acids in cell culture (SILAC)

Ong, S. E., Kratchmarova, I. & Mann, M., 2003, In : Journal of Proteome Research. 2(2), p. 173-81

Research output: Contribution to journalJournal articleResearch

2002

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling

Pandey, A., Ibarrola, N., Kratchmarova, I., Fernandez, M. M., Constantinescu, S. N., Ohara, O., Sawasdikosol, S., Lodish, H. F. & Mann, M., 2002, In : Journal of Biological Chemistry. 12, p. 12

Research output: Contribution to journalJournal articleResearch

A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes.

Kratchmarova, I., Kalume, D. E., Blagoev, B., Scherer, P. E., Podtelejnikov, A. V., Molina, H., Bickel, P. E., Andersen, J. S., Fernandez, M. M., Bunkenborg, J., Roepstorff, P., Kristiansen, K., Lodish, H. F., Mann, M. & Pandey, A., 1. Mar 2002, In : Molecular and Cellular Proteomics. 1, 3, p. 213-22 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases

Pandey, A., Blagoev, B., Kratchmarova, I., Fernandez, M. M., Nielsen, M. M., Kristiansen, T. Z., Ohara, O., Podtelejnikov, A. V., Roche, S., Lodish, H. F. & Mann, M., 2002, In : Oncogene. 21(52), p. 8029-36

Research output: Contribution to journalJournal articleResearchpeer-review

Inhibition of adipocyte differentiation by resistin-like molecule alpha. Biochemical characterization of its oligomeric nature.

Blagoev, B., Kratchmarova, I., Nielsen, M. M., Fernandez, M. M., Voldby, J., Andersen, J. S., Kristiansen, K., Pandey, A. & Mann, M., 1. Nov 2002, In : Journal of Biological Chemistry. 277, 44, p. 42011-6 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Opposing effects of fatty acids and acyl-CoA esters on conformation and cofactor recruitment of peroxisome proliferator-activated receptors

JØrgensen, C., Krogsdam, A-M., Kratchmarova, I., Willson, T. M., Knudsen, J., Mandrup, S. & Kristiansen, K., 2002, In : Annals of the New York Academy of Sciences. 967, 1, p. 431-439 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Role of adipocyte lipid-binding protein (ALBP) and acyl-CoA binding protein (ACBP) in PPAR-mediated transactivation

Helledie, T., Jørgensen, C., Antonius, A., Krogsdam, A-M., Kratchmarova, I., Kristiansen, K. & Mandrup, S., 2002, In : Molecular and Cellular Biochemistry. 239, 1-2, p. 157-164

Research output: Contribution to journalJournal articleResearch

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

Ong, S. E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A. & Mann, M., 2002, In : Molecular and Cellular Proteomics. 1(5), p. 376-86

Research output: Contribution to journalJournal articleResearch

2001

Acyl-CoA esters antagonize the effects of ligands on peroxisome proliferator-activated receptor alpha conformation, DNA binding, and interaction with Co-factors.

Elholm, M., Dam, I., Jorgensen, C., Krogsdam, A. M., Holst, D., Kratchmarova, I., Gottlicher, M., Gustafsson, J. A., Berge, R., Flatmark, T., Knudsen, J., Mandrup, S. & Kristiansen, K., 15. Jun 2001, In : Journal of Biological Chemistry. 276, 24, p. 21410-16 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Automatic inducer addition and harvesting of recombinant Escherichia coli cultures based on indirect on-line estimation of biomass concentration and specific growth rate

Eriksen, N. T., Kratchmarova, I., Neve, S., Kristiansen, K. & Iversen, J. J. L., 2001, In : Biotechnology and Bioengineering (Print). 75, p. 355-61

Research output: Contribution to journalJournal articleResearch

Modulation of Keratinocyte Gene Expression and Differentiation by PPAR-Selective Ligands and Tetradecylthioacetic Acid

Westergaard, M., Henningsen, J., Svendsen, M. L., Johansen, C., Jensen, U. B., Schrøder, H. D., Kratchmarova, I., Berge, R. K., Iversen, L., Bolund, L., Kragballe, K. & Kristiansen, K., 2001, In : Journal of Investigative Dermatology. 116, 5, p. 702-12 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1999

Microaffinity columns for analysis of protein-protein interactions

Kussmann-Gerber, S., Kratchmarova, I., Mandrup, S. & Kristiansen, K., 1999, In : Analytical Biochemistry. 271, 1, p. 102-105

Research output: Contribution to journalJournal articleResearchpeer-review