• Campusvej 55

    5230 Odense M

    Denmark

1982 …2019
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Research Output 1982 2019

2019

Anogenital distance in children born of mothers with polycystic ovary syndrome: the Odense Child Cohort

Glintborg, D., Jensen, R. C., Schmedes, A. V., Brandslund, I., Kyhl, H. B., Nielsen, T. K. & Andersen, M. S., 2. Oct 2019, In : Human reproduction (Oxford, England). 34, 10, p. 2061-2070

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Mothers
Penis
Denmark
Research
68 Downloads (Pure)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jørgensen, M. E., Grarup, N. & 9 others, Pedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., Feb 2019, In : Diabetologia. 62, 2, p. 292-305

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Exome
Albuminuria
Meta-Analysis
Kidney Diseases
Type 2 Diabetes Mellitus
22 Downloads (Pure)

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3. Jan 2019, In : American Journal of Human Genetics. 104, 1, p. 112-138

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Mitochondrial Genes
Body Mass Index
Insulin
Adipocytes
Type 2 Diabetes Mellitus
54 Downloads (Pure)

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

Olesen, M. N., Soelberg, K., Debrabant, B., Nilsson, A. C., Lillevang, S. T., Grauslund, J., Brandslund, I., Madsen, J. S., Paul, F., Smith, T. J., Jarius, S. & Asgari, N., 11. Mar 2019, In : Journal of Neuroinflammation. 16, 12 p., 59.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Optic Neuritis
Cerebrospinal Fluid
Cohort Studies
Prospective Studies
Intermediate Filaments

EGFR and EGFR ligands in serum in healthy women: reference intervals and age dependency

Kjær, I. M., Olsen, D. A., Alnor, A., Brandslund, I., Bechmann, T. & Madsen, J. S., 16. Jul 2019, In : Clinical Chemistry and Laboratory Medicine. 57, 12, p. 1948-1955

Research output: Contribution to journalJournal articleResearchpeer-review

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Ligands
Serum
Transforming Growth Factors

Home Management of Warfarin Treatment Through a Real-Time Supervised Telemedicine Solution: A Randomized Controlled Trial

Brasen, C. L., Madsen, J. S., Parkner, T. & Brandslund, I., Feb 2019, In : Telemedicine and e-Health. 25, 2, p. 109-115

Research output: Contribution to journalJournal articleResearchpeer-review

Warfarin
Randomized Controlled Trials
International Normalized Ratio
Point-of-Care Systems
Delivery of Health Care

Mannan-binding lectin and cardiovascular events and mortality in type 2 diabetes: a cohort study of 7,307 patients in the Danish DD2 cohort

Gedebjerg, A., Bjerre, M., Steffensen, R., Nielsen, J. S., Rungby, J., Friborg, S., Brandslund, I., Thiel, S., Beck-Nielsen, H., Sørensen, H. T., Krarup Hansen, T. & Thomsen, R. W., Oct 2019, In : Diabetologia.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

91 Downloads (Pure)

Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, N. R., Vestergaard, H., Hansen, T., Hansen, T. H., Pedersen, O. & Nielsen, T., Jun 2019, In : Diabetologia. 62, 6, p. 1024-1035

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Bilophila
Bacterial DNA
Microbiota
Denmark

Myalgisk encefalomyelitis eller kronisk træthedssyndrom

Translated title of the contribution: Myalgic encephalomyelitis or chronic fatigue syndromeBrinth, L., Nielsen, H., Varming, K., Boonen, S. E., Ebsen, A. G., Fernandez-Guerra, P., Schou, A-S., Mehlsen, J., Gregersen, N., Brandslund, I. & Olsen, R. K. J., 10. Jun 2019, In : Ugeskrift for Laeger. 181, V08180570.

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic Fatigue Syndrome
Research

Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma

Poulsen, H. E., Weimann, A., Henriksen, T., Kjær, L. K., Larsen, E. L., Carlsson, E. R., Christensen, C. K., Brandslund, I. & Fenger, M., Dec 2019, In : Free Radical Biology and Medicine. 145, p. 336-341

Research output: Contribution to journalReviewResearchpeer-review

Nucleic Acids
Creatinine
Nucleosides
Urine
Plasmas
35 Downloads (Pure)

Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey

Pharmacogenomics Education Working Group (PGxEWG), Jun 2019, In : Pharmacogenomics. 20, 9, p. 643-657

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pharmacy Schools
Pharmacogenetics
Medical Schools
Education
Health Occupations

Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

The Danish IBD Genetics Working Group, Apr 2019, In : Alimentary Pharmacology and Therapeutics. 49, 7, p. 890-903

Research output: Contribution to journalJournal articleResearchpeer-review

Interleukin-18
Inflammatory Bowel Diseases
Ulcerative Colitis
Tumor Necrosis Factor-alpha
Crohn Disease

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

CHD Exome+ Consortium, Mar 2019, In : Nature Genetics. 51, 3, p. 452-469

Research output: Contribution to journalJournal articleResearchpeer-review

Homeostasis
Lipids
Fats
Exome
White Adipose Tissue

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

Rabing Brix Petersen, E., Witte, D. R., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, ReproGen Consortium, INTERVAL Study, T2D-GENES Consortium, the MAGIC Investigators & Understanding Society Scientific Group, Jul 2019, In : Nature Genetics. 51, 7, p. 1191-1192

Research output: Contribution to journalComment/debateResearchpeer-review

Energy Metabolism
Body Mass Index
Proteins
37 Downloads (Pure)

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

Sun, J., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Pedersen, O., Nielsen, J. S., Rungby, J., Christensen, C., Brandslund, I., Kristiansen, K., Jun, W., Hansen, T. & Gjesing, A. P., 15. Aug 2019, In : PLOS ONE. 14, 8, 10 p., e0220805.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
diabetes
Glutamate Decarboxylase

Serum vitamin K1 associated to micro- and/or macroangiopathy in individuals with and without diabetes: Serum vitamin K1 and micro- and macroangiopathy

Bøgh Andersen, I., Brasen, C. L., Nasimi, H., Stougaard, M., Bliddal, M., Green, A., Schmedes, A., Brandslund, I. & Madsen, J. S., 2019, (In preparation).

Research output: Contribution to conference without publisher/journalPaperResearchpeer-review

Polycystic Ovary Syndrome
Third Pregnancy Trimester
Mothers
Cortisone
Fasting

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

Kofoed Kjær, L., Cejvanovic, V., Henriksen, T., Hansen, T., Pedersen, O., Kjeldahl Christensen, C., Torp-Pedersen, C., Alexander Gerds, T., Brandslund, I., Mandrup-Poulsen, T. & Enghusen Poulsen, H., 4. Jun 2019, In : Free Radical Research. 53, 6, p. 694-703

Research output: Contribution to journalJournal articleResearchpeer-review

Medical problems
Type 2 Diabetes Mellitus
Nucleic Acids
RNA
Oxidation
2018
84 Downloads (Pure)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Finnish Diabetic Nephropathy Study (FinnDiane), 1. Jul 2018, In : Diabetes. 67, 7, p. 1414-1427

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Glomerular Filtration Rate
Sample Size
101 Downloads (Pure)

Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis

Loft, N. D., Skov, L., Iversen, L., Gniadecki, R., Dam, T. N., Brandslund, I., Hoffmann, H. J., Andersen, M. R., Dessau, R. B., Bergmann, A. C., Møller Andersen, N., Andersen, P. S., Bank, S., Vogel, U. & Andersen, V., 22. May 2018, In : Pharmacogenomics Journal. 18, 3, p. 494–500

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Psoriasis
Single Nucleotide Polymorphism
Psoriatic Arthritis
Interleukin-13
Pharmacogenetics
128 Downloads (Pure)

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 others, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjær, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y. H., Færgeman, N. J. & Gerhart-Hines, Z., 3. Jul 2018, In : Cell Metabolism. 28, 1, p. 159-174.e11

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Homeostasis
Fats
Energy Metabolism
Insulin Resistance
Adipocytes

Cerebrospinal fluid biomarkers of inflammation and neurodegeneration in acute optic neuritis

Olesen, M. N., Soelberg, K., Nilsson, A. C., Jarius, S., Madsen, J. S., Grauslund, J., Smith, T. J., Lillevang, S. T., Brandslund, I., Paul, F. & Asgari, N., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

79 Downloads (Pure)

Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort of newly diagnosed patients with type 2 diabetes: a cohort profile

Christensen, D. H., Nicolaisen, S. K., Berencsi, K., Beck-Nielsen, H., Rungby, J., Friborg, S., Brandslund, I., Christiansen, J. S., Vaag, A., Sørensen, H. T., Nielsen, J. S. & Thomsen, R. W., 1. Apr 2018, In : BMJ Open. 8, 4, 11 p., e017273.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Research
Diabetes Complications
Albuminuria
Diabetic Neuropathies
52 Downloads (Pure)
Open Access
File
Immunoassay
Ligands
Serum
Limit of Detection
Betacellulin

False increase of glycated hemoglobin due to aspirin interference in Tosoh G8 analyzer

Gils, C., Reinholdt, B., Andreassen, B. D., Brandslund, I. & Vinholt, P. J., 25. Apr 2018, In : Clinical Chemistry and Laboratory Medicine. 56, 5, p. e118-e120

Research output: Contribution to journalComment/debateResearchpeer-review

49 Downloads (Pure)

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Mägi, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., Preuss, M. H. & 95 others, Prins, B. P., Guo, X., Bielak, L. F., Below, J. E., Bowden, D. W., Chambers, J. C., Kim, Y. J., Ng, M. C. Y., Petty, L. E., Sim, X., Zhang, W., Bennett, A. J., Bork-Jensen, J., Brummett, C. M., Canouil, M., Ec Kardt, K-U., Fischer, K., Kardia, S. L. R., Kronenberg, F., Läll, K., Liu, C-T., Locke, A. E., Luan, J., Ntalla, I., Nylander, V., Schönherr, S., Schurmann, C., Yengo, L., Bottinger, E. P., Brandslund, I., Christensen, C., Dedoussis, G., Florez, J. C., Ford, I., Franco, O. H., Frayling, T. M., Giedraitis, V., Hackinger, S., Hattersley, A. T., Herder, C., Ikram, M. A., Ingelsson, M., Jørgensen, M. E., Jørgensen, T., Kriebel, J., Kuusisto, J., Ligthart, S., Lindgren, C. M., Linneberg, A., Lyssenko, V., Mamakou, V., Meitinger, T., Mohlke, K. L., Morris, A. D., Nadkarni, G., Pankow, J. S., Peters, A., Sattar, N., Stančáková, A., Strauch, K., Taylor, K. D., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Tuomilehto, J., Witte, D. R., Dupuis, J., Peyser, P. A., Zeggini, E., Loos, R. J. F., Froguel, P., Ingelsson, E., Lind, L., Groop, L., Laakso, M., Collins, F. S., Jukema, J. W., Palmer, C. N. A., Grallert, H., Metspalu, A., Dehghan, A., Köttgen, A., Abecasis, G. R., Meigs, J. B., Rotter, J. I., Marchini, J., Pedersen, O., Hansen, T., Langenberg, C., Wareham, N. J., Stefansson, K., Gloyn, A. L., Morris, A. P., Boehnke, M. & McCarthy, M. I., Nov 2018, In : Nature Genetics. 50, 11, p. 1505–1513

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Genome-Wide Association Study
Epigenomics
Equipment and Supplies

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Groop, L. C., Leslie, R. D., Grant, S. F. A. & Bone Mineral Density in Childhood Study, Nov 2018, In : Diabetes Care. 41, 11, p. 2396-2403

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
Glycolysis
76 Downloads (Pure)

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

Sode, J., Bank, S., Vogel, U., Andersen, P. S., Sørensen, S. B., Bojesen, A. B., Andersen, M. R., Brandslund, I., Dessau, R. B., Hoffmann, H. J., Glintborg, B., Hetland, M. L., Locht, H., Heegaard, N. H. & Andersen, V., 12. Sep 2018, In : BMC Medical Genetics. 19, 16 p., 165.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Tumor Necrosis Factor-alpha
Interleukin-18
Odds Ratio
Confidence Intervals
Antirheumatic Agents
134 Downloads (Pure)

Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

Loft, N. D., Skov, L., Rasmussen, M. K., Gniadecki, R., Dam, T. N., Brandslund, I., Hoffmann, H. J., Andersen, M. R., Dessau, R. B., Bergmann, A. C., Andersen, N. M., Abildtoft, M. K., Andersen, P. S., Hetland, M. L., Glintborg, B., Bank, S., Vogel, U. & Andersen, V., 1. Feb 2018, In : PLOS ONE. 13, 2, 12 p., e0192010.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
psoriasis
Psoriatic Arthritis
arthritis
Genetic Polymorphisms
Polymorphism
104 Downloads (Pure)

Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Christensen, R., Heitmann, B. L., Andersen, K. W., Nielsen, O. H., Sørensen, S. B., Jawhara, M., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F. & 21 others, Bojesen, A. B., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Bennike, T. B., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Boye, M., Werner, L., Nielsen, C. L., Munk, H. L., Nexøe, A. B., Ellingsen, T., Holmskov, U., Kjeldsen, J. & Andersen, V., Feb 2018, In : B M J Open. 8, 2, 17 p., e018166.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Precision Medicine
Cohort Studies
Prospective Studies
Tumor Necrosis Factor-alpha
Hidradenitis Suppurativa

Pathophysiology-based phenotyping in type 2 diabetes: A clinical classification tool

Stidsen, J. V., Henriksen, J. E., Olsen, M. H., Thomsen, R. W., Nielsen, J. S., Rungby, J., Ulrichsen, S. P., Berencsi, K., Kahlert, J. A., Friborg, S. G., Brandslund, I., Nielsen, A. A., Christiansen, J. S., Sørensen, H. T., Olesen, T. B. & Beck-Nielsen, H., Jul 2018, In : Diabetes - Metabolism: Research and Reviews (Print Edition). 34, 5, 11 p., e3005.

Research output: Contribution to journalJournal articleResearchpeer-review

Medical problems
Type 2 Diabetes Mellitus
Insulin Resistance
Glucocorticoids
Insulin
31 Downloads (Pure)

Personalized laboratory medicine: A patient-centered future approach

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., Podgornik, H., Repič Lampret, B., Trebušak Podkrajšek, K., Sipeky, C., Van Schaik, R., Brandslund, I., Vermeersch, P., Schwab, M. & Marc, J., 27. Nov 2018, In : Clinical Chemistry and Laboratory Medicine. 56, 12, p. 1981–1991

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Precision Medicine
Medicine
Biostatistics
Cost effectiveness
Restoration
121 Downloads (Pure)

Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

Gedebjerg, A., Almdal, T. P., Berencsi, K., Rungby, J., Nielsen, J. S., Witte, D. R., Friborg, S., Brandslund, I., Vaag, A., Beck-Nielsen, H., Sørensen, H. T. & Thomsen, R. W., Jan 2018, In : Journal of Diabetes and its Complications. 32, 1, p. 34-40

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Diabetes Complications
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Confidence Intervals
Hypertriglyceridemia

Prognostic and predictive value of EGFR and EGFR-ligands in blood of breast cancer patients: a systematic review

Kjaer, I. M., Bechmann, T., Brandslund, I. & Madsen, J. S., 2018, In : Clinical Chemistry and Laboratory Medicine. 56, 5, p. 688-701

Research output: Contribution to journalReviewResearchpeer-review

Epidermal Growth Factor Receptor
Blood
Ligands
Biomarkers
Publications

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 31 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Brandslund, I., Christensen, C., Jensen, G. B., Jørgensen, M. E., Thuesen, B. H. & CHD Exome+ Consortium, 2018, In : Nature Genetics. 50, 1, p. 26-41

Research output: Contribution to journalJournal articleResearchpeer-review

Energy Metabolism
Body Mass Index
Genome-Wide Association Study
Proteins
Adipocytes
102 Downloads (Pure)

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 others, Badia, R. M., Udler, M., Leong, A., Kaur, V., Flannick, J., Jørgensen, T., Linneberg, A., Jørgensen, M. E., Witte, D. R., Christensen, C., Brandslund, I., Appel, E. V., Scott, R. A., Luan, JA., Langenberg, C., Wareham, N. J., Pedersen, O., Zorzano, A., Florez, J. C., Hansen, T., Ferrer, J., Mercader, J. M. & Torrents, D., 30. May 2018, In : Nature Communications. 9, 1, 2162.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
Research Ethics Committees
Clinical Medicine
Medical problems
Computational Biology
Type 2 Diabetes Mellitus
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 others, Badia, R. M., Udler, M., Leong, A., Kaur, V., Flannick, J., Jørgensen, T., Linneberg, A., Jørgensen, M. E., Witte, D. R., Christensen, C., Brandslund, I., Appel, E. V., Scott, R. A., Luan, J., Langenberg, C., Wareham, N. J., Pedersen, O., Zorzano, A., Florez, J. C., Hansen, T., Ferrer, J., Mercader, J. M. & Torrents, D., 1. Dec 2018, In : Nature Communications. 9, 1, 14 p., 321.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Medical problems
Type 2 Diabetes Mellitus
genome
Genes
Genome-Wide Association Study
79 Downloads (Pure)

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D. R. & Hansen, T., 1. Apr 2018, In : Nature Genetics. 50, 4, p. 559-571

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Causality
Odds Ratio
42 Downloads (Pure)

Testosterone levels in third trimester in polycystic ovary syndrome: Odense Child Cohort

Glintborg, D., Jensen, R. C., Bentsen, K., Schmedes, A. V., Brandslund, I., Kyhl, H. B., Bilenberg, N. & Andersen, M. S., 1. Oct 2018, In : The Journal of clinical endocrinology and metabolism. 103, 10, p. 3819–3827

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycystic Ovary Syndrome
Third Pregnancy Trimester
Testosterone
Sex Hormone-Binding Globulin
Pregnant Women
2017

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning, A. K., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S. B., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M. J., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S. M., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E-S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J. C. N., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G. R., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Jul 2017, In : Diabetes. 66, 7, p. 2019-2032

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Type 2 Diabetes Mellitus
Fasting
Insulin
Exome
Population
202 Downloads (Pure)

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Andersen, V., Holmskov, U., Sørensen, S. B., Jawhara, M., Andersen, K. W., Bygum, A., Sylvester Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F., Nielsen, O. H. & 18 others, Christensen, R., Bojesen, A. B., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Heitmann, B., Boye, M., Lindgaard Nielsen, C., Werner, L., Kjeldsen, J. & Ellingsen, T., 2017, In : Nutrients. 9, 5, 16 p., 499.

Research output: Contribution to journalLetterResearchpeer-review

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File
Precision Medicine
tumor necrosis factors
lifestyle
medicine
inflammatory bowel disease

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, T., Pedersen, O., Christensen, C. K., Torp-Pedersen, C., Gerds, T. A., Brandslund, I., Mandrup-Poulsen, T. & Poulsen, H. E., 2017, In : Diabetes Care. 40, 2, p. 1771-1778

Research output: Contribution to journalJournal articleResearchpeer-review

Type 2 Diabetes Mellitus
Cohort Studies
Prospective Studies
RNA
8-hydroxyguanosine

Cell-Free DNA in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

Spindler, K-L. G., Boysen, A. K., Pallisgård, N., Johansen, J. S., Tabernero, J., Sørensen, M. M., Jensen, B. V., Hansen, T. F., Sefrioui, D., Andersen, R. F., Brandslund, I. & Jakobsen, A., 2017, In : Oncologist. 22, 9, p. 1049-1055

Research output: Contribution to journalReviewResearchpeer-review

Meta-Analysis
Colorectal Neoplasms
DNA
Magnetics
Mutation

Differential intrathecal inflammatory markers in acute optic neuritis and later conversion to multiple sclerosis

Olesen, M. N., Soelberg, K., Nilsson, A. C., Jarius, S., Madsen, J. S., Grauslund, J., Smith, T. J., Lillevang, S. T., Brandslund, I., Paul, F., Weinshenker, B. G. & Asgari, N., 2017. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Optic Neuritis
Cerebrospinal Fluid
Interleukin-10
Interleukin-17
Interleukin-6
61 Downloads (Pure)

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 31 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M-P., Ebeling, T., Eiriksdottir, G., Hansen, T., Jensen, G. B., Jørgensen, M. E. & Charge Diabetes Working Group, 2017, In : Nature Genetics. 49, p. 1758–1766

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Exome
Lipids
Type 2 Diabetes Mellitus
Coronary Artery Disease
LDL Cholesterol
66 Downloads (Pure)

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

Gjesing, A. P., Rui, G., Lauenborg, J., Have, C. T., Hollensted, M., Andersson, E., Grarup, N., Sun, J., Quan, S., Brandslund, I., Damm, P., Pedersen, O., Wang, J. & Hansen, T., 2017, In : Journal of the Endocrine Society. 1, 6, p. 681-690

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Gestational Diabetes
Type 2 Diabetes Mellitus
Diet
Glucose Intolerance
Introns
56 Downloads (Pure)

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 31 others, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Käräjämäki, A., Kooperberg, C., Linneberg, A., Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Mägi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Christensen, C. K., Hansen, T. & Understanding Society Scientific Group, 2017, In : Circulation: Cardiovascular Genetics. 10, 5, e001778.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Meta-Analysis
Exome
Genome-Wide Association Study
114 Downloads (Pure)

Rare and low-frequency coding variants alter human adult height

Marouli, E., Graff, M., Medina-Gómez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T. & 31 others, Locke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G. R., Aben, K. K., Adair, L. S., Alam, D. S., Albrecht, E., Allin, K. H., Allison, M. A., Amouyel, P., Appel, E. V. R., Arveiler, D., Asselbergs, F. W., Auer, P. L., Balkau, B., Banas, B., Bang, L. E., Benn, M., Bergmann, S., Brandslund, I., Christensen, C., Hansen, T., Jensen, G. B., Jørgensen, M. E. & EPIC-InterAct Consortium, 9. Feb 2017, In : Nature. 542, 7640, p. 186-190

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Alleles
Insulin-Like Growth Factor Binding Protein 4
Pregnancy-Associated Plasma Protein-A
Multifactorial Inheritance
Genome-Wide Association Study

Rhodopsin in plasma from patients with diabetic retinopathy - development and validation of digital ELISA by Single Molecule Array (Simoa) technology

Petersen, E. R. B., Olsen, D. A., Christensen, H., Hansen, S. B., Christensen, C. & Brandslund, I., 2017, In : Journal of Immunological Methods. 446, p. 60-69

Research output: Contribution to journalJournal articleResearchpeer-review

Rhodopsin
Diabetic Retinopathy
Western World
Young Adult