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Research Output 2003 2019

2019

[58mCo]Co‐DOTA‐hEGF: A novel ligand for targeted Auger electron therapy of glioblastoma using convection‐enhanced delivery

Laursen, V., Baun, C., Aaberg Poulsen, C., Olsen, B. B., Dam, J. H., Jensen, A. & Thisgaard, H., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, S1, p. S511-S512

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Neoplasms
Somatostatin Receptors
68Ga-DOTATATE
64Cu-DOTATATE
HEPES

Multi-Curie Production of Gallium-68 on a Biomedical Cyclotron

Kumlin, J., Dam, J. H., Chua, C. J., Borjian, S., Kassaian, A., Hook, B., Zeisler, S., Schaffer, P. & Thisgaard, H., 1. Oct 2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 46, Suppl. 1, p. S39 1 p., OP-086.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

14 Downloads (Pure)

Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Mitran, B., Thisgaard, H., Rinne, S., Dam, J. H., Azami, F., Tolmachev, V., Orlova, A. & Rosenström, U., 19. Nov 2019, In : Scientific Reports. 9, 11 p., 17086.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Bombesin Receptors
Chelating Agents
Cobalt
Prostatic Neoplasms
Neoplasms
2018
35 Downloads (Pure)
Open Access
File
Cobalt
Neoplasms
Half-Life
Ligands
oleylamine

Effects of insulin and blood glucose on FDG-uptake in a mouse lung tumour model

Baun, C., Nielsen, A. L., Gerke, O., Falch Braas, K., Olsen, B. B., Thisgaard, H. & Høilund-Carlsen, P. F., Oct 2018, In : European Journal of Nuclear Medicine and Molecular Imaging. 45, Suppl 1, p. S563 1 p., EP-0662.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Selection of optimal macrocyclic chelator for high contrast PET imaging of gastrin releasing peptide receptor using cobalt-labeled bombesin antagonist RM26

Mitran, B., Thisgaard, H., Rinne, S. S., Rosenström, U., Azamy, F., Dam, J. H., Tolmachev, V. & Orlova, A., Oct 2018, In : European Journal of Nuclear Medicine and Molecular Imaging. 45, Suppl. 1, p. S672-S673 EP-0913.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2017

[55Co]Co-DOTA-PSMA-617 for PET/CT Imaging of Prostate Cancer in Xenograft Mice

Dam, J. H., Olsen, B. B., Baun, C. & Thisgaard, H., 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, Suppl. 1, p. S640 1 p., P 458 .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

[55Co]Co-DOTA-PSMA-617 for PET/CT Imaging of Prostate Cancer in Xenograft Mice

Dam, J. H., Olsen, B. B., Baun, C. & Thisgaard, H., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

[58mCo]Co-DOTA-PSMA-617: A novel radioligand for Auger electron therapy of prostate cancer

Thisgaard, H., Olsen, B. B., Baun, C. & Dam, J. H., 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, Suppl. 1, p. S327 1 p., P 167.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

A PSMA Ligand Labeled with Cobalt-55 for PET Imaging of Prostate Cancer

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 2017, In : Molecular Imaging and Biology. 19, 6, p. 915–922

Research output: Contribution to journalJournal articleResearchpeer-review

Cobalt
Prostatic Neoplasms
Ligands
Heterografts
Neoplasms
117 Downloads (Pure)

Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411

Holmboe, S., Hansen, P. L., Thisgaard, H., Block, I., Müller, C., Langkjær, N., Høilund-Carlsen, P. F., Olsen, B. B. & Mollenhauer, J., 2017, In : PLOS ONE. 12, 5, 12 p., e0178286.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Somatostatin Receptors
somatostatin
lung neoplasms
Somatostatin
Stem cells

Formulation and in vivo biodistribution of 57Co-porphyrin-labelled hydrophobic liquid nanoparticles

Hervella, P., Dam, J. H., Thisgaard, H., Baun, C., Olsen, B. B., Høilund-Carlsen, P. F. & Needham, D., 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, Suppl. 2, p. 307-308 OP-533.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

165 Downloads (Pure)

High contrast pet imaging of GRPR expression in prostate cancer using cobalt-labeled bombesin antagonist RM26

Mitran, B., Thisgaard, H., Rosenström, U., Dam, J. H., Larhed, M., Tolmachev, V. & Orlova, A., 2017, In : Contrast Media & Molecular Imaging (Print). 2017, 10 p., 6873684.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Bombesin Receptors
Cobalt
Prostatic Neoplasms
Radioactivity
Neoplasms
105 Downloads (Pure)

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

Garousi, J., Andersson, K. G., Dam, J. H., Olsen, B. B., Mitran, B., Orlova, A., Buijs, J., Ståhl, S., Löfblom, J., Thisgaard, H. & Tolmachev, V., 2017, In : Scientific Reports. 7, 10 p., 5961.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epidermal Growth Factor Receptor
Radioisotopes
Neoplasms
Cobalt Radioisotopes
Cobalt Isotopes
2016

Evaluation of nucleolin and somatostatin receptor targeting for therapeutic delivery to lung cancer stem cells

Hansen, P. L., Holmboe, S., Olsen, B. B., Thisgaard, H., Christiansen, H., Schmidt, S., Block, I., Müller, C., Langkjær, N., Jørgensen, P. T., Vogel, S., Wengel, J., Høilund-Carlsen, P. F. & Mollenhauer, J., 27. Jun 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

134 Downloads (Pure)

Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery

Thisgaard, H., Halle, B., Aaberg-Jessen, C., Olsen, B. B., Nautrup Therkelsen, A. S., Dam, J. H., Langkjær, N., Munthe, S., Någren, K., Høilund-Carlsen, P. F. & Kristensen, B. W., 2016, In : Theranostics. 6, 12, p. 2278-2291

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

In Vivo Evaluation of a Bombesin Analogue Labeled with Ga-68 and Co-55/57

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 2016, In : Molecular Imaging and Biology. 18, 3, p. 368-376

Research output: Contribution to journalJournal articleResearchpeer-review

Radiation-resistant cancer stem cells are sensitive to Auger-electron emission

Olsen, B. B., Høilund-Carlsen, P. F. & Thisgaard, H., 16. Oct 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Radiation-resistant cancer stem cells are sensitive to Auger-electron emission

Olsen, B. B., Høilund-Carlsen, P. F. & Thisgaard, H., 2016, In : European Journal of Nuclear Medicine and Molecular Imaging. 43, suppl. 1, p. S480 1 p., EP674.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2015

Auger electron therapy for glioblastoma

Thisgaard, H., Halle, B., Høilund-Carlsen, P. F., Kristensen, B. W. & Aaberg-Jessen, C., 23. Dec 2015, Patent No. WO2015EP63823, 19. Jun 2015, Priority date 20. Jun 2014, Priority No. EP20140173218

Research output: PatentResearch

Estimation of Tumor Volumes by 11C-MeAIB and 18F-FDG PET in an Orthotopic Glioblastoma Rat Model

Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015, In : Journal of Nuclear Medicine. 56, 10, p. 1562-1568

Research output: Contribution to journalJournal articleResearchpeer-review

Fluorodeoxyglucose F18
Glioblastoma
Tumor Burden
Acids
Neoplasms

Estimation of tumour volumes by [11C]MeAIB and [18F]FDG PET in an orthotopic glioblastoma model

Aaberg-Jessen, C., Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 1 Supplement, p. 423-425 1 p., P173.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Estimation of tumour volumes by [11C]MeAIB and [18F]FDG PET in an orthotopic glioblastoma model

Aaberg-Jessen, C., Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Novel treatment strategy for glioblastomas using Auger-electron therapy and concomitant chemotherapy: in vitro studies

Therkelsen, A., Olsen, B. B., Halle, B., Høilund-Carlsen, P. F. & Thisgaard, H., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 1 Supplement, p. 113 1 p., OP275.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

PET imaging with the non-pure positron emitters: 55Co, 86Y and 124I

Braad, P-E., Hansen, S. B., Thisgaard, H. & Høilund-Carlsen, P. F., 9. Apr 2015, In : Physics in Medicine and Biology. 60, 9, p. 3479-3497 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Computer-Assisted Image Processing
Isotopes
Electrons
Signal-To-Noise Ratio

Relationship between somatostatin receptor expression, DNA damage and cell survival in cancer cells incubated with a cobalt-labeled octreotide analogue

Olsen, B. B., Dam, J. H., Müller, C., Mollenhauer, J., Høilund-Carlsen, P. F. & Thisgaard, H., 29. May 2015.

Research output: Contribution to conference without publisher/journalPosterResearch

Seeing the unseen-bioturbation in 4D: Tracing bioirrigation in marine sediment using positron emission tomography and computed tomography

Delefosse, M., Kristensen, E., Crunelle, D., Braad, P. E., Dam, J. H., Thisgaard, H., Thomassen, A. & Høilund-Carlsen, P. F., 4. Apr 2015, In : PLOS ONE. 10, 4, p. 1-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Geologic Sediments
positron-emission tomography
Positron emission tomography
bioturbation
marine sediments

The use of radiocobalt as a label improves PET imaging of EGFR using DOTA-conjugated affibody molecules

Garousi, J., Anderson, K., Dam, J. H., Olsen, B. B., Orlova, A., Buijs, J., Ståhl, S., Thisgaard, H. & Tolmachew, V., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 1 Supplement, p. 244 1 p., OP582.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2014

Convection-enhanced delivery of the Auger-electron-emitter I-125-UdR: A highly efficient therapy in an Orthotopic Glioblastoma Xenograft Model

Halle, B., Thisgaard, H., Aaberg-Jessen, C., Olsen, B. B., Dam, J. H., Langkjaer, N., Munthe, S., Någren, K., Hoilund-Carlsen, P. F. & Kristensen, B. W., 2014, In : Neuro-Oncology. 16, p. 1

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Evaluation of Cobalt-Labeled Octreotide Analogs for Molecular Imaging and Auger Electron-Based Radionuclide Therapy

Thisgaard, H., Olsen, B. B., Dam, J. H., Bollen, P., Mollenhauer, J. & Høilund-Carlsen, P. F., 29. May 2014, In : Journal of Nuclear Medicine. 55, 8, p. 1311-1316

Research output: Contribution to journalJournal articleResearchpeer-review

Octreotide
Cobalt
Radioisotopes
Electrons
Therapeutic Uses

In Vivo Evaluation of a Bombesin Analogue Labelled with 68Ga and 55/57Co

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 18. Oct 2014, In : European Journal of Nuclear Medicine and Molecular Imaging. 41, 2. Supplement, p. S251 1 p., OP414.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

1071 Downloads (Pure)

Fully Automated Radiosynthesis and Formulation of [11C]MeAIB Applied for In Vivo Imaging of Glioblastoma

Dam, J. H., Halle, B., Thisgaard, H., Hvidsten, S., Kristensen, B. W. & Någren, K., 17. May 2013.

Research output: Contribution to conference without publisher/journalPosterResearch

Open Access
File
161 Downloads (Pure)

Fully Automated Radiosynthesis and Formulation of [11C]MeAIB Applied for In Vivo Imaging of Glioblastoma

Dam, J. H., Halle, B., Thisgaard, H., Hvidsten, S., Kristensen, B. W. & Någren, K., 2013, In : Journal of Labelled Compounds and Radiopharmaceuticals. 56, S1, p. S112 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
File

Novel radioisotope-based nanomedical approaches

Olsen, B. B., Thisgaard, H., Vogel, S., Thomassen, M., Kruse, T. A., Needham, D., Mollenhauer, J. & Høilund-Carlsen, P. F., 2013, In : European Journal of Nanomedicine. 5, 4, p. 181–193

Research output: Contribution to journalJournal articleResearchpeer-review

Set-up of Mouse Models for Nanodrug Testing

Hansen, P. L., Riedel, A., Schmidt, S., Terp, M. G., Trojnar, J. H., Schifter, S., Olsen, B. B., Thisgaard, H., Ditzel, H., Høilund-Carlsen, P. F. & Mollenhauer, J., 2013.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2012

Experimental verification of Auger emitter radiotoxicity using exotic radionuclides

Jensen, M., Koester, U. & Thisgaard, H., 2012, In : Radiotherapy & Oncology. 102, Suppl. 1, p. 178-179

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Quantitative 124I-PET: Evaluation of Prompt Gamma Coincidence Correction on a Clinical PET/CT system

Braad, P-E., Hansen, S. B., Thisgaard, H. & Høilund-Carlsen, P. F., 27. Oct 2012.

Research output: Contribution to conference without publisher/journalPosterResearch

2011

A new and simple calibration-independent method for measuring the beam energy of a cyclotron

Gagnon, K., Jensen, M., Thisgaard, H., Publicover, J., Lapi, S., McQuarrie, S. & Ruth, T. J., Jan 2011, In : Applied Radiation and Isotopes. 69, 1, p. 247–253

Research output: Contribution to journalJournal articleResearchpeer-review

Cyclotrons
Radiotherapy
Radioisotopes
radioactive isotopes
cyclotrons

Production and dosimetric aspects of the potent Auger emitter 58mCo for targeted radionuclide therapy of small tumors

Thisgaard, H., Elema, DR. & Jensen, M., 2011, In : Medical Physics. 38, 8, p. 4535-4541 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Radiosynthesis of 55Co- and 58mCo-labelled DOTATOC for positron emission tomography imaging and targeted radionuclide therapy

Thisgaard, H., Olesen, M. L. & Dam, J. H., 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, 12, p. 758-762 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

SPECT imaging with the therapeutic Auger electron emitter Er-165

Thisgaard, H., Hvidsten, S. & Bollen, P., Sep 2011.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2010

Production and dosimetric aspects of the potent Auger emitter 58mCo for targeted radionuclide therapy of small tumours

Thisgaard, H., Jensen, M. & Elema, D. R., 2010, In : European Journal of Nuclear Medicine and Molecular Imaging. 37, Suppl 2, p. S356-S357

Research output: Contribution to journalConference articleResearchpeer-review

Production of therapeutic quantities of 64Cu and 119Sb for radionuclide therapy using a small PET cyclotron

Thisgaard, H., Jensen, M. & Elema, D. R., 2010. 2 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2009
Cyclotrons
Radioisotopes
radioactive isotopes
cyclotrons
Tumors
2008

119Sb — A potent Auger emitter for targeted radionuclide therapy

Thisgaard, H. & Jensen, M., 7. Aug 2008, In : Medical Physics. 35, 9, p. 3839-3846

Research output: Contribution to journalJournal articleResearchpeer-review

Accelerator based Production of Auger-electron-emitting Isotopes for Radionuclide Therapy

Thisgaard, H., 27. Aug 2008, Risø National Laboratory. 127 p.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch