Henrik Holbech

Search results

• 2020

  Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

  Baumann, L., Holbech, H., Schmidt-Posthaus, H., Moissl, A. P., Hennies, M., Tiedemann, J., Weltje, L., Segner, H. & Braunbeck, T., Jan 2020, In: Chemosphere. 238, p. 124589 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • OECD
  • marker
  • test
  • gene
  • endocrine system

• ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

  Holbech, H., Matthiessen, P., Hansen, M., Schüürmann, G., Knapen, D., Reuver, M., Flamant, F., Sachs, L., Kloas, W., Hilscherova, K., Leonard, M., Arning, J., Strauss, V., Iguchi, T. & Baumann, L., 22. Apr 2020, In: International Journal of Molecular Sciences . 21, 8

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Endocrine disrupters
  • Environmental testing
  • vertebrates
  • Environmental Health
  • health
  52 Downloads (Pure)

• Raman spectroscopy as a tool for viability assessment of planktonic organisms in UV treated ballast water

  Andreasen, M., Lundgreen, K., Holbech, H. & Hedegaard, M. A. B., 1. Sep 2020, In: Vibrational Spectroscopy. 110, 8 p., 103142.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Algae
  • Raman spectroscopy
  • Water
  • Salinum
  • Raman scattering

• Thymus development in the zebrafish (Danio rerio) from an ecoimmunology perspective

  Kernen, L., Rieder, J., Duus, A., Holbech, H., Segner, H. & Bailey, C., 11. Dec 2020, In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • thymocytes
  • Danio rerio
  • Thymus Gland
  • immune system
  • teleost

• Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

  Knapen, D., Stinckens, E., Cavallin, J. E., Ankley, G. T., Holbech, H., Villeneuve, D. L. & Vergauwen, L., 21. Jul 2020, In: Environmental Science & Technology. 54, 14, p. 8491-8499

  Research output: Contribution to journal › Journal article › Research › peer-review

  • hormone
  • Thyroid Hormones
  • Fish
  • Testing
  • Endocrine Disruptors
• 2019

  Ballast water UV treatment effectiveness, an ATR-FTIR approach: Detection of UV damage in micro-phytoplankton

  Jouvet, L., Holbech, H. & Hedegaard, M. A. B., 2. Dec 2019.

  Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

  File

  • ballast water
  • water treatment
  • phytoplankton
  • detection
  • analysis
  8 Downloads (Pure)

• Development of a novel automated analytical method for viability assessment of phytoplankton used for validation of ballast water treatment systems

  Lundgreen, K., Eckford-Soper, L., Pedersen, K. L. & Holbech, H., Oct 2019, In: Journal of Applied Phycology. 31, 5, p. 2941-2955 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ballast water
  • water treatment
  • phytoplankton
  • analytical methods
  • viability

• Installation and use of ballast water treatment systems – Implications for compliance and enforcement

  Gerhard, W. A., Lundgreen, K., Drillet, G., Baumler, R., Holbech, H. & Gunsch, C. K., 1. Nov 2019, In: Ocean & Coastal Management. 181, 104907.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ballast water
  • enforcement
  • compliance
  • water treatment
  • vessel

• Use of standard test organisms for sound validation of UV-based ballast water treatment systems

  Lundgreen, K., Holbech, H., Pedersen, K. L., Petersen, G. I., Andreasen, R. R., George, C., Drillet, G. & Andersen, M., 1. Jul 2019, In: Marine Pollution Bulletin. 144, p. 253-264

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ballast water
  • test organism
  • Water treatment
  • water treatment
  • Acoustic waves
• 2018

  A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β-trenbolone

  Ankley, G. T., Coady, K. K., Gross, M., Holbech, H., Levine, S. L., Maack, G. & Williams, M., 2018, In: Environmental Toxicology and Chemistry. 37, 8, p. 2064-2078

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Trenbolone Acetate
  • androgen
  • vertebrate
  • Androgens
  • Vertebrates

• Ballast Water and Invasive Species in the Arctic

  Holbech, H. & Pedersen, K. L., 1. Apr 2018, Arctic Marine Resource Governance and Development. Vestergaard, N., A. Kaiser, B., Fernandez, L. & Larsen, J. N. (eds.). Springer, p. 115-137 (Springer Polar Sciences).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  • ballast water
  • invasive species
  • marine ecosystem
  • shipping
  • regulation

• Investigation of the potential endocrine effect of nitrate in zebrafish Danio rerio and brown trout Salmo trutta

  Bjerregaard, P., Kinnberg, K. L., Pedersen Mose, M. & Holbech, H., 2018, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 211, p. 32-40

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Trout
  • Nitrates
  • Vitellogenins
  • Nitrites
  • Sex Ratio
  212 Downloads (Pure)

• Raman Spectroscopy as a Tool to Measure Viability of Planktonic Organisms in UV-Treated Ballast Water

  Andreasen, M., Lundgreen, K., Holbech, H. & Hedegaard, M. A. B., Oct 2018.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

• Statistical analysis of ecotoxicity studies: A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment

  Green, J. W., Springer, T. A. & Holbech, H., 1. Jul 2018, United States: John Wiley & Sons Ltd. 416 p.

  Research output: Monograph/anthology/thesis/report › Monograph › Research

  • statistical analysis
  • interpretation
  • experiment
  • regression
  • computer simulation

• Two common mild analgesics have no effect on general endocrine mediated endpoints in zebrafish (Danio rerio)

  Morthorst, J. E., Lund, B., Holbech, H. & Bjerregaard, P., Jan 2018, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 204, p. 63-70

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Acetaminophen
  • Analgesics
  • Vitellogenins
  • Prostaglandins E
  • Prostaglandins
  187 Downloads (Pure)

• UV fluences required for compliance with ballast water discharge standards using two approved methods for algal viability assessment

  Lundgreen, K., Holbech, H., Pedersen, K. L., Petersen, G. I., Andreasen, R. R., Drillet, G., George, C. & Andersen, M., 28. Aug 2018, In: Marine Pollution Bulletin. 135, p. 1090-1100

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ballast water
  • compliance
  • viability
  • Compliance
  • Algae

• Vitellogenin concentrations in feral Danish brown trout have decreased: An effect of improved sewage treatment in rural areas?

  Morthorst, J. E., Korsholm Mathiesen, K., Holbech, H., Pedersen, K. L. & Bjerregaard, P., 2018, In: Environmental Toxicology and Chemistry. 37, 3, p. 839-845

  Research output: Contribution to journal › Journal article › Research › peer-review

  • feral
  • Sewage treatment
  • Vitellogenins
  • Trout
  • Waste Water
• 2017

  Current Limitations and Recommendations to Improve Testing for the Environmental Assessment of Endocrine Active Substances

  Coady, K. K., Biever, R. C., Denslow, N. D., Gross, M., Guiney, P. D., Holbech, H., Karouna-Renier, N. K., Katsiadaki, I., Krueger, H., Levine, S. L., Maack, G., Williams, M., Wolf, J. C. & Ankley, G. T., 2017, In: Integrated Environmental Assessment and Management. 13, 2, p. 302–316

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Environmental assessment
  • environmental assessment
  • recommendation
  • test
  • androgen
  223 Downloads (Pure)

• Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)

  Ruppert, K., Geiß, C., Askem, C., Benstead, R., Brown, R., Coke, M., Ducrot, V., Egeler, P., Holbech, H., Hutchinson, T. H., Kinnberg, K. L., Lagadic, L., Le Page, G., Macken, A., Matthiessen, P., Ostermann, S., Schimera, A., Schmitt, C., Seeland-Fremer, A., Smith, A. J. & 2 others, Weltje, L. & Oehlmann, J., 2017, In: Chemosphere. 181, p. 589-599

  Research output: Contribution to journal › Journal article › Research › peer-review

  • OECD
  • toxicity test
  • tributyltin
  • chemical
  • snail

• Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances

  Matthiessen, P., Ankley, G. T., Biever, R. C., Bjerregaard, P., Borgert, C., Brugger, K., Blankinship, A., Chambers, J., Coady, K., Constantine, L., Dang, Z., Denslow, N. D., Dreier, D. A., Dungey, S., Gray, L. E., Gross, M., Guiney, P. D., Hecker, M., Holbech, H., Iguchi, T. & 28 others, Kadlec, S., Karouna-Renier, N., Katsiadaki, I., Kawashima, Y., Kloas, W., Krueger, H., Kumar, A., Lagadic, L., Leopold, A., Levine, S. L., Maack, G., Marty, S., Meador, J., Mihaich, E., Odum, J., Ortego, L., Parrott, J., Pickford, D., Roberts, M., Schaefers, C., Schwarz, T., Solomon, K., Verslycke, T., Weltje, L., Wheeler, J. R., Williams, M., Wolf, J. C. & Yamazaki, K., 2017, In: Integrated Environmental Assessment and Management. 13, 2, p. 267–279

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • endocrine system
  • hazard
  • hazard assessment
  • risk assessment
  • evaluation
  297 Downloads (Pure)

• Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

  Geiss, C., Ruppert, K., Askem, C., Barroso, C., Faber, D., Ducrot, V., Holbech, H., Hutchinson, T. H., Kajankari, P., Kinnberg, K. L., Lagadic, L., Matthiessen, P., Morris, S., Neiman, M., Penttinen, O-P., Sanchez-Marin, P., Teigeler, M., Weltje, L. & Oehlmann, J., 2017, In: Ecotoxicology. 26, 3, p. 370–382

  Research output: Contribution to journal › Journal article › Research › peer-review

  • prochloraz
  • Trenbolone Acetate
  • Organisation for Economic Co-Operation and Development
  • OECD
  • New Zealand

• Viability assessment of invasive microplankton in ship’s treated ballast water

  Lundgreen, K., Holbech, H. & Pedersen, K. L., 22. Jun 2017. 1 p.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2016

  Current limitations and a path forward to improve testing for the environmental assessment of endocrine active substances

  Coady, K. K., Biever, R. C., Denslow, N. D., Gross, M., Guiney, P. D., Holbech, H., Karouna-Renier, N. K., Katsiadaki, I., Krueger, H. O., Levine, S. L., Maack, G., Williams, M., Wolf, J. & Ankley, G. T., 25. May 2016. 1 p.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  Open Access

  • environmental assessment
  • testing
  • screening
  • wolves
  • assays

• Is nitrate an endocrine active compound in fish?

  Pedersen Mose, M., Kinnberg, K. L., Bjerregaard, P. & Holbech, H., 25. May 2016.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  • nitrates
  • Salmo trutta
  • Danio rerio
  • fish
  • sex ratio

• Neuro-endocrine disruption in molluscs: Effects of pharmaceuticals on a serotonin- and dopamine dependent system

  Holbech, H., Bech Sanderhoff, L., Waller, S. P. & Pedersen, K. L., 25. May 2016.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  Open Access

  • molluscs
  • serotonin
  • Lymnaea stagnalis
  • drugs
  • embryo (animal)

• Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis

  Charles, S., Ducrot, V., Azam, D., Benstead, R., Brettschneider, D., De Schamphelaere, K., Filipe Goncalves, S., Green, J. W., Holbech, H., Hutchinson, T. H., Faber, D., Laranjeiro, F., Matthiessen, P., Norrgren, L., Oehlmann, J., Reategui-Zirena, E., Seeland-Fremer, A., Teigeler, M., Thome, J-P., Tobor Kaplon, M. & 2 others, Weltje, L. & Lagadic, L., 25. Jul 2016, In: Regulatory Toxicology and Pharmacology. 81, p. 47-56

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lymnaea
  • Ponds
  • Toxicity Tests
  • Reproduction
  • Organisation for Economic Co-Operation and Development

• Sexual disruption in zebrafish (Danio rerio) exposed to mixtures of 17α-ethinylestradiol and 17β-trenbolone

  Örn, S., Holbech, H. & Norrgren, L., 4. Jan 2016, In: Environmental Toxicology and Pharmacology. 41, January, p. 225-231

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Androgens
  • Trenbolone Acetate
  • Estrogens
  • Ethinyl Estradiol
  • Fish
• 2015

  Endocrine-disrupting effect of the ultraviolet filter benzophenone-3 in zebrafish, Danio rerio

  Kinnberg, K. L., Petersen, G. I., Albrektsen, M., Minghlani, M., Awad, S. M., Holbech, B. F., Green, J. W., Bjerregaard, P. & Holbech, H., 2015, In: Environmental Toxicology and Chemistry. 34, 12, p. 2833-2840 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • oxybenzone
  • dose-response relationship
  • filter
  • Fish
  • sex ratio

• Information/testing strategies for identification of substances with endocrine disrupting properties

  Christiansen, S., Holbech, H., Bjerregaard, P. & Hass, U., 16. Oct 2015. 1 p.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

  • Health

• Let's discuss: Endocrine Biomarkers in bivalves - facts and pitfalls

  Morthorst, J. E., Pedersen, K. L., Holbech, H. & Bjerregaard, P., 2015.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2014

  Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

  Ducrot, V., Askem, C., Azam, D., Brettschneider, D., Brown, R., Charles, S., Coke, M., Collinet, M., Delignette-Muller, M-L., Forfait-Dubuc, C., Holbech, H., Hutchinson, T., Jach, A., Kinnberg, K. L., Lacoste, C., Le Page, G., Matthiessen, P., Oehlmann, J., Rice, L., Roberts, E. & 6 others, Ruppert, K., Davis, J. E., Veauvy, C., Weltje, L., Wortham, R. & Lagadic, L., Dec 2014, In: Regulatory Toxicology and Pharmacology. 70, 3, p. 605-614 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Development and validation of a partial life-cycle test with Potamopyrgus antipodarum

  Geiss, C., Holbech, H., Kinnberg, K. L., Oehlmann, J., Hutchinson, T. & Ruppert, K., 2014.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research

  • Potamopyrgus antipodarum
  • tributyltin
  • life cycle (organisms)
  • molluscs
  • testing

• Development of a Cellular Efflux Pump Inhibition Assay (CEPIA) for Lymnaea stagnalis eggs

  Pedersen, K. L. & Holbech, H., 2014.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Development of a standard protocol for using Lymnea stagnalis eggs for the assessment of mixture toxicity in freshwater mollusks.

  Pedersen, K. L., Bech Sanderhoff, L. & Holbech, H., 17. Nov 2014.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Evaluation of yolk protein levels as estrogenic biomarker in bivalves; Comparison of the alkali labile phosphate method (ALP) and a species specific immunoassay (ELISA)

  Morthorst, J. E., Holbech, H., Jeppesen, M., Kinnberg, K. L., Pedersen, K. L. & Bjerregaard, P., Nov 2014, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 166, November, p. 88-95

  Research output: Contribution to journal › Journal article › Research › peer-review

• Identity and synthesis of the major egg yolk proteins of the fresh water mussel Unio tumidus and its occurence and inducability during a full reproductive cycle

  Pedersen, K. L., Morthorst, J. E., Holbech, H., Kinnberg, K. L., Madsen, S. & Bjerregaard, P., 2014.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone

  Baumann, L., Knörr, S., Keiter, S., Nagel, T., Rehberger, K., Volz, S., Oberrauch, S., Schiller, V., Fenske, M., Holbech, H., Segner, H. & Braunbeck, T., Nov 2014, In: Environmental Toxicology and Chemistry. 33, 11, p. 2488-2496

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Trenbolone Acetate
  • androgen
  • Vitellogenins
  • Hatches
  • Androgens

• Proposal of how to update the standard information requirements in REACH, PPPR and BPR – a testing strategy for identification of endocrine disruptors

  Holbech, H., Bjerregaard, P., Hass, U. & Christiansen, S., 2014.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Communication

  • plant protection product
  • endocrine disruptor
  • regulation
  • EC regulation
  • product

• Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol

  Baumann, L., Knörr, S., Keiter, S., Rehberger, K., Volz, S., Schiller, V., Fenske, M., Holbech, H., Segner, H. & Braunbeck, T., 15. Aug 2014, In: Toxicology and Applied Pharmacology. 278, 3, p. 230-237 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ethinyl Estradiol
  • Hatches
  • Estrogens
  • Vitellogenins
  • Sexual Development

• Session 2 – Identification of endocrine disruptors and amendments of standard information requirements

  Christiansen, S. & Holbech, H., 7. May 2014, In: TemaNord. 2014, 529, p. 15-17 3 p.

  Research output: Contribution to journal › Journal article › Communication

  • endocrine disruptor
  • combination effect
  • regulation
  • effect
• 2013

  Baseline growth and reproductive parameters in Lymnaea stagnalis for OECD test guideline development: optimization of diets and culturing conditions

  Tasker, J. & Holbech, H., 19. May 2013. 1 p.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  • Lymnaea stagnalis
  • flakes
  • sweet potatoes
  • diet
  • Polycentridae

• Can yolk proteins in molluscs be used as biomarkers for estrogenic effect?

  Holbech, H., Kinnberg, K. L., Morthorst, J. E., Pedersen, K. L. & Bjerregaard, P., 28. May 2013. 1 p.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

• Development and validation of OECD test guidelines on mollusc reproductive toxicity tests

  Lagadic, L., Holbech, H. & Virginie Ducrot, INRA France, 19. May 2013.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research

  • reproductive toxicology
  • molluscs
  • standard operating procedures
  • testing
  • ring tests

• Discharge from houses in the open land: A potential source of oestrogenicity to headwater streams

  Morthorst, J. E., Korsholm Mathiesen, K., Holbech, H., Pedersen, K. L. & Bjerregaard, P., 28. May 2013.

  Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

• Estrogenic effect of the phytoestrogen biochanin A in zebrafish, Danio rerio, and brown trout, Salmo trutta

  Holbech, H., Schröder, K. D., Nielsen, L. M., Brande-Lavridsen, N., Holbech, B. F. & Bjerregaard, P., 19. Sep 2013, In: Aquatic Toxicology. 144-145, p. 19-25

  Research output: Contribution to journal › Journal article › Research › peer-review

• Evaluation of yolk protein as biomarkers for endocrine disruption in molluscs

  Morthorst, J. E., Holbech, H., Kinnberg, K. L., Pedersen, K. L. & Bjerregaard, P., Nov 2013.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Information/testing strategy for identification of substances with endocrine disrupting properties

  Hass, U., Christiansen, S., Bjerregaard, P. & Holbech, H., 30. Jun 2013, CeHOS, DANISH CENTRE ON ENDOCRINE DISRUPTERS. 52 p.

  Research output: Monograph/anthology/thesis/report › Report › Commissioned

  • testing
  • United States Environmental Protection Agency
  • plant protection

• Statistical refinements for data analysis of mollusc reproduction tests: an example with Lymnaea stagnalis

  Charles, S., 20. May 2013.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research

  • mollusc
  • data analysis
  • mortality
  • experimental design
  • snail

• The maturity index as a tool to facilitate the interpretation of changes in vitellogenin production and sex ratio in the Fish Sexual Development Test

  Baumann, L., Holbech, H., Keiter, S., Kinnberg, K. L., Knörr, S., Nagel, T. & Braunbeck, T., 15. Mar 2013, In: Aquatic Toxicology. 128– 129, p. 34– 42 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vitellogenins
  • Sexual Development
  • Endocrine Disruptors
  • sex ratio
  • Sex Ratio

• The use of yolk protein as biomarkers for endocrine disruption in molluscs

  Holbech, H., Kinnberg, K. L., Bjerregaard, P., Morthorst, J. E. & Pedersen, K. L., 19. May 2013. 1 p.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  • molluscs
  • Unio pictorum
  • fish
  • histology
  • gender