Henrik Holbech

2022

Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Morthorst, J. E., Holbech, H., De Crozé, N., Matthiessen, P. & LeBlanc, G. A., 17. May 2022, (E-pub ahead of print) In: Integrated Environmental Assessment and Management.

Research output: Contribution to journal › Journal article › Research › peer-review

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2021

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

Audouze, K. M. L., Zgheib, E., Abass, K., Baig, A. H., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P. E. G., Lupu, D. I., Palaniswamy, S., Rautio, A., Sapounidou, M. & Martin, O. V., Dec 2021, In: Frontiers in Toxicology . 3, 10 p., 787017.

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Investigation of the in vivo estrogenicity of the UV-filters 4-methylbenzylidene camphor and octyl methoxy cinnamate in rainbow trout (Oncorhynchus mykiss)

Søgaard, R., Holbech, H., Nørum, U. & Bjerregaard, P., Nov 2021, In: Ecotoxicology and Environmental Safety. 224, 6 p., 112657.

Research output: Contribution to journal › Journal article › Research › peer-review

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2020

Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

Baumann, L., Holbech, H., Schmidt-Posthaus, H., Moissl, A. P., Hennies, M., Tiedemann, J., Weltje, L., Segner, H. & Braunbeck, T., Jan 2020, In: Chemosphere. 238, p. 124589 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Holbech, H., Matthiessen, P., Hansen, M., Schüürmann, G., Knapen, D., Reuver, M., Flamant, F., Sachs, L., Kloas, W., Hilscherova, K., Leonard, M., Arning, J., Strauss, V., Iguchi, T. & Baumann, L., 22. Apr 2020, In: International Journal of Molecular Sciences . 21, 8

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Raman spectroscopy as a tool for viability assessment of planktonic organisms in UV treated ballast water

Andreasen, M., Lundgreen, K., Holbech, H. & Hedegaard, M. A. B., 1. Sep 2020, In: Vibrational Spectroscopy. 110, 8 p., 103142.

Research output: Contribution to journal › Journal article › Research › peer-review

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Thymus development in the zebrafish (Danio rerio) from an ecoimmunology perspective

Kernen, L., Rieder, J., Duus, A., Holbech, H., Segner, H. & Bailey, C., Dec 2020, In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 333, 10, p. 805-819

Research output: Contribution to journal › Journal article › Research › peer-review

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Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

Knapen, D., Stinckens, E., Cavallin, J. E., Ankley, G. T., Holbech, H., Villeneuve, D. L. & Vergauwen, L., 21. Jul 2020, In: Environmental Science & Technology. 54, 14, p. 8491-8499

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Østrogene effekter i ferskvandsvandsmiljøet

Morthorst, J. E., Holbech, H., Pedersen, K. L. & Bjerregaard, P., 2020, In: Vand & Jord. 27, 2, p. 44-46 3 p.

Research output: Contribution to journal › Journal article › Communication

2019

Ballast water UV treatment effectiveness, an ATR-FTIR approach: Detection of UV damage in micro-phytoplankton

Jouvet, L., Holbech, H. & Hedegaard, M. A. B., 2. Dec 2019.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

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Development of a novel automated analytical method for viability assessment of phytoplankton used for validation of ballast water treatment systems

Lundgreen, K., Eckford-Soper, L., Pedersen, K. L. & Holbech, H., Oct 2019, In: Journal of Applied Phycology. 31, 5, p. 2941-2955 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Installation and use of ballast water treatment systems – Implications for compliance and enforcement

Gerhard, W. A., Lundgreen, K., Drillet, G., Baumler, R., Holbech, H. & Gunsch, C. K., 1. Nov 2019, In: Ocean & Coastal Management. 181, 104907.

Research output: Contribution to journal › Journal article › Research › peer-review

Use of standard test organisms for sound validation of UV-based ballast water treatment systems

Lundgreen, K., Holbech, H., Pedersen, K. L., Petersen, G. I., Andreasen, R. R., George, C., Drillet, G. & Andersen, M., 1. Jul 2019, In: Marine Pollution Bulletin. 144, p. 253-264

Research output: Contribution to journal › Journal article › Research › peer-review

2018

A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β-trenbolone

Ankley, G. T., Coady, K. K., Gross, M., Holbech, H., Levine, S. L., Maack, G. & Williams, M., 2018, In: Environmental Toxicology and Chemistry. 37, 8, p. 2064-2078

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

Ballast Water and Invasive Species in the Arctic

Holbech, H. & Pedersen, K. L., 1. Apr 2018, Arctic Marine Resource Governance and Development. Vestergaard, N., A. Kaiser, B., Fernandez, L. & Larsen, J. N. (eds.). Springer, p. 115-137 (Springer Polar Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

Investigation of the potential endocrine effect of nitrate in zebrafish Danio rerio and brown trout Salmo trutta

Bjerregaard, P., Kinnberg, K. L., Pedersen Mose, M. & Holbech, H., 2018, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 211, p. 32-40

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Raman Spectroscopy as a Tool to Measure Viability of Planktonic Organisms in UV-Treated Ballast Water

Andreasen, M., Lundgreen, K., Holbech, H. & Hedegaard, M. A. B., Oct 2018.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Statistical analysis of ecotoxicity studies: A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment

Green, J. W., Springer, T. A. & Holbech, H., 1. Jul 2018, United States: John Wiley & Sons Ltd. 416 p.

Research output: Book/report › Monograph › Research

Two common mild analgesics have no effect on general endocrine mediated endpoints in zebrafish (Danio rerio)

Morthorst, J. E., Lund, B., Holbech, H. & Bjerregaard, P., Jan 2018, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 204, p. 63-70

Research output: Contribution to journal › Journal article › Research › peer-review

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UV fluences required for compliance with ballast water discharge standards using two approved methods for algal viability assessment

Lundgreen, K., Holbech, H., Pedersen, K. L., Petersen, G. I., Andreasen, R. R., Drillet, G., George, C. & Andersen, M., 28. Aug 2018, In: Marine Pollution Bulletin. 135, p. 1090-1100

Research output: Contribution to journal › Journal article › Research › peer-review

Vitellogenin concentrations in feral Danish brown trout have decreased: An effect of improved sewage treatment in rural areas?

Morthorst, J. E., Korsholm Mathiesen, K., Holbech, H., Pedersen, K. L. & Bjerregaard, P., 2018, In: Environmental Toxicology and Chemistry. 37, 3, p. 839-845

Research output: Contribution to journal › Journal article › Research › peer-review

2017

Current Limitations and Recommendations to Improve Testing for the Environmental Assessment of Endocrine Active Substances

Coady, K. K., Biever, R. C., Denslow, N. D., Gross, M., Guiney, P. D., Holbech, H., Karouna-Renier, N. K., Katsiadaki, I., Krueger, H., Levine, S. L., Maack, G., Williams, M., Wolf, J. C. & Ankley, G. T., 2017, In: Integrated Environmental Assessment and Management. 13, 2, p. 302–316

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Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)

Ruppert, K., Geiß, C., Askem, C., Benstead, R., Brown, R., Coke, M., Ducrot, V., Egeler, P., Holbech, H., Hutchinson, T. H., Kinnberg, K. L., Lagadic, L., Le Page, G., Macken, A., Matthiessen, P., Ostermann, S., Schimera, A., Schmitt, C., Seeland-Fremer, A., Smith, A. J., & 2 othersWeltje, L. & Oehlmann, J., 2017, In: Chemosphere. 181, p. 589-599

Research output: Contribution to journal › Journal article › Research › peer-review

Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances

Matthiessen, P., Ankley, G. T., Biever, R. C., Bjerregaard, P., Borgert, C., Brugger, K., Blankinship, A., Chambers, J., Coady, K., Constantine, L., Dang, Z., Denslow, N. D., Dreier, D. A., Dungey, S., Gray, L. E., Gross, M., Guiney, P. D., Hecker, M., Holbech, H., Iguchi, T., & 28 othersKadlec, S., Karouna-Renier, N., Katsiadaki, I., Kawashima, Y., Kloas, W., Krueger, H., Kumar, A., Lagadic, L., Leopold, A., Levine, S. L., Maack, G., Marty, S., Meador, J., Mihaich, E., Odum, J., Ortego, L., Parrott, J., Pickford, D., Roberts, M., Schaefers, C., Schwarz, T., Solomon, K., Verslycke, T., Weltje, L., Wheeler, J. R., Williams, M., Wolf, J. C. & Yamazaki, K., 2017, In: Integrated Environmental Assessment and Management. 13, 2, p. 267–279

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Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

Geiss, C., Ruppert, K., Askem, C., Barroso, C., Faber, D., Ducrot, V., Holbech, H., Hutchinson, T. H., Kajankari, P., Kinnberg, K. L., Lagadic, L., Matthiessen, P., Morris, S., Neiman, M., Penttinen, O-P., Sanchez-Marin, P., Teigeler, M., Weltje, L. & Oehlmann, J., 2017, In: Ecotoxicology. 26, 3, p. 370–382

Research output: Contribution to journal › Journal article › Research › peer-review

Viability assessment of invasive microplankton in ship’s treated ballast water

Lundgreen, K., Holbech, H. & Pedersen, K. L., 22. Jun 2017. 1 p.

Research output: Contribution to conference without publisher/journal › Poster › Research

2016

Current limitations and a path forward to improve testing for the environmental assessment of endocrine active substances

Coady, K. K., Biever, R. C., Denslow, N. D., Gross, M., Guiney, P. D., Holbech, H., Karouna-Renier, N. K., Katsiadaki, I., Krueger, H. O., Levine, S. L., Maack, G., Williams, M., Wolf, J. & Ankley, G. T., 25. May 2016. 1 p.

Research output: Contribution to conference without publisher/journal › Poster › Research

Open Access

Is nitrate an endocrine active compound in fish?

Pedersen Mose, M., Kinnberg, K. L., Bjerregaard, P. & Holbech, H., 25. May 2016.

Research output: Contribution to conference without publisher/journal › Poster › Research

Neuro-endocrine disruption in molluscs: Effects of pharmaceuticals on a serotonin- and dopamine dependent system

Holbech, H., Bech Sanderhoff, L., Waller, S. P. & Pedersen, K. L., 25. May 2016.

Research output: Contribution to conference without publisher/journal › Poster › Research

Open Access

Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis

Charles, S., Ducrot, V., Azam, D., Benstead, R., Brettschneider, D., De Schamphelaere, K., Filipe Goncalves, S., Green, J. W., Holbech, H., Hutchinson, T. H., Faber, D., Laranjeiro, F., Matthiessen, P., Norrgren, L., Oehlmann, J., Reategui-Zirena, E., Seeland-Fremer, A., Teigeler, M., Thome, J-P., Tobor Kaplon, M., & 2 othersWeltje, L. & Lagadic, L., 25. Jul 2016, In: Regulatory Toxicology and Pharmacology. 81, p. 47-56

Research output: Contribution to journal › Journal article › Research › peer-review

Sexual disruption in zebrafish (Danio rerio) exposed to mixtures of 17α-ethinylestradiol and 17β-trenbolone

Örn, S., Holbech, H. & Norrgren, L., 4. Jan 2016, In: Environmental Toxicology and Pharmacology. 41, January, p. 225-231

Research output: Contribution to journal › Journal article › Research › peer-review

2015

Endocrine-disrupting effect of the ultraviolet filter benzophenone-3 in zebrafish, Danio rerio

Kinnberg, K. L., Petersen, G. I., Albrektsen, M., Minghlani, M., Awad, S. M., Holbech, B. F., Green, J. W., Bjerregaard, P. & Holbech, H., Dec 2015, In: Environmental Toxicology and Chemistry. 34, 12, p. 2833-2840 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

Information/testing strategies for identification of substances with endocrine disrupting properties

Christiansen, S., Holbech, H., Bjerregaard, P. & Hass, U., 16. Oct 2015. 1 p.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Let's discuss: Endocrine Biomarkers in bivalves - facts and pitfalls

Morthorst, J. E., Pedersen, K. L., Holbech, H. & Bjerregaard, P., 2015.

Research output: Contribution to conference without publisher/journal › Poster › Research

2014

Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Ducrot, V., Askem, C., Azam, D., Brettschneider, D., Brown, R., Charles, S., Coke, M., Collinet, M., Delignette-Muller, M-L., Forfait-Dubuc, C., Holbech, H., Hutchinson, T., Jach, A., Kinnberg, K. L., Lacoste, C., Le Page, G., Matthiessen, P., Oehlmann, J., Rice, L., Roberts, E., & 6 othersRuppert, K., Davis, J. E., Veauvy, C., Weltje, L., Wortham, R. & Lagadic, L., Dec 2014, In: Regulatory Toxicology and Pharmacology. 70, 3, p. 605-614 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Development and validation of a partial life-cycle test with Potamopyrgus antipodarum

Geiss, C., Holbech, H., Kinnberg, K. L., Oehlmann, J., Hutchinson, T. & Ruppert, K., 2014.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research

Development of a Cellular Efflux Pump Inhibition Assay (CEPIA) for Lymnaea stagnalis eggs

Pedersen, K. L. & Holbech, H., 2014.

Research output: Contribution to conference without publisher/journal › Poster › Research

Development of a standard protocol for using Lymnea stagnalis eggs for the assessment of mixture toxicity in freshwater mollusks.

Pedersen, K. L., Bech Sanderhoff, L. & Holbech, H., 17. Nov 2014.

Research output: Contribution to conference without publisher/journal › Poster › Research

Evaluation of yolk protein levels as estrogenic biomarker in bivalves; Comparison of the alkali labile phosphate method (ALP) and a species specific immunoassay (ELISA)

Morthorst, J. E., Holbech, H., Jeppesen, M., Kinnberg, K. L., Pedersen, K. L. & Bjerregaard, P., Nov 2014, In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 166, November, p. 88-95

Research output: Contribution to journal › Journal article › Research › peer-review

Identity and synthesis of the major egg yolk proteins of the fresh water mussel Unio tumidus and its occurence and inducability during a full reproductive cycle

Pedersen, K. L., Morthorst, J. E., Holbech, H., Kinnberg, K. L., Madsen, S. & Bjerregaard, P., 2014.

Research output: Contribution to conference without publisher/journal › Poster › Research

Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone

Baumann, L., Knörr, S., Keiter, S., Nagel, T., Rehberger, K., Volz, S., Oberrauch, S., Schiller, V., Fenske, M., Holbech, H., Segner, H. & Braunbeck, T., Nov 2014, In: Environmental Toxicology and Chemistry. 33, 11, p. 2488-2496

Research output: Contribution to journal › Journal article › Research › peer-review

Proposal of how to update the standard information requirements in REACH, PPPR and BPR – a testing strategy for identification of endocrine disruptors

Holbech, H., Bjerregaard, P., Hass, U. & Christiansen, S., 2014.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Communication

Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol

Baumann, L., Knörr, S., Keiter, S., Rehberger, K., Volz, S., Schiller, V., Fenske, M., Holbech, H., Segner, H. & Braunbeck, T., 15. Aug 2014, In: Toxicology and Applied Pharmacology. 278, 3, p. 230-237 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Session 2 – Identification of endocrine disruptors and amendments of standard information requirements

Christiansen, S. & Holbech, H., 7. May 2014, In: TemaNord. 2014, 529, p. 15-17 3 p.

Research output: Contribution to journal › Journal article › Communication

2013

Baseline growth and reproductive parameters in Lymnaea stagnalis for OECD test guideline development: optimization of diets and culturing conditions

Tasker, J. & Holbech, H., 19. May 2013. 1 p.

Research output: Contribution to conference without publisher/journal › Poster › Research

Henrik Holbech

Research output

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