• J.B. Winsløws Vej 21, 3.

    5000 Odense C

    Denmark

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2020

Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability

Plain, A., Pan, W., O'Neill, D., Ure, M., Beggs, M. R., Farhan, M., Dimke, H., Cordat, E. & Alexander, R. T., 18. Mar 2020, In : International Journal of Molecular Sciences. 21, 6, 18 p., 2074.

Research output: Contribution to journalJournal articleResearchpeer-review

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2019

A bacterial display system for effective selection of protein-biotin ligase BirA variants with novel peptide specificity

Granhøj, J., Dimke, H. & Svenningsen, P., 11. Mar 2019, In : Scientific Reports. 9, 1, 11 p., 4118.

Research output: Contribution to journalJournal articleResearchpeer-review

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Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption

Lee, J. J., Liu, X., O'Neil, D., Beggs, M. R., Weissgerber, P., Flockerzi, V., Chen, X-Z., Dimke, H. & Alexander, R. T., 6. Jun 2019, In : JCI Insight. 4, 11, 14 p., e128013.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Granhøj, J., Dimke, H. & Svenningsen, P., 3. Oct 2019, In : Journal of visualized experiments : JoVE. 2019, 152, 8 p., e60266.

Research output: Contribution to journalJournal articleResearchpeer-review

Forskere efterspørger små og mellemstore bevillinger

Christiansen, P. M., Dimke, H., Norn, M-T., Wohlert, J. & Zinner, N. T., 31. Oct 2019, In : Forskningspolitikk.

Research output: Contribution to journalJournal articleCommunication

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Nephrotic syndrome is associated with increased plasma K + concentration, intestinal K + losses, and attenuated urinary K + excretion: a study in rats and humans

Ydegaard, R., Svenningsen, P., Bistrup, C., Andersen, R. F., Stubbe, J., Buhl, K. B., Marcussen, N., Hinrichs, G. R., Iraqi, H., Zamani, R., Dimke, H. & Jensen, B. L., 1. Dec 2019, In : American Journal of Physiology: Renal Physiology. 317, 6, p. F1549-F1562

Research output: Contribution to journalJournal articleResearchpeer-review

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter

Cheng, L., Poulsen, S. B., Wu, Q., Esteva-Font, C., Olesen, E. T. B., Peng, L., Olde, B., Leeb-Lundberg, L. M. F., Pisitkun, T., Rieg, T., Dimke, H. & Fenton, R. A., Aug 2019, In : Journal of the American Society of Nephrology. 30, 8, p. 1454-1470

Research output: Contribution to journalJournal articleResearchpeer-review

The kidney anion exchanger 1 affects tight junction properties via claudin-4

Lashhab, R., Rumley, A. C., Arutyunov, D., Rizvi, M., You, C., Dimke, H., Touret, N., Zimmermann, R., Jung, M., Chen, X-Z., Alexander, T. & Cordat, E., 1. Dec 2019, In : Scientific Reports. 9, 1, 16 p., 3099.

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Transcriptional regulation of Hepatic Stellate Cell activation in NASH

Marcher, A-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. Feb 2019, In : Scientific Reports. 9, 1, 55 p., 2324.

Research output: Contribution to journalJournal articleResearchpeer-review

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TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning

Beggs, M. R., Lee, J. J., Busch, K., Raza, A., Dimke, H., Weissgerber, P., Engel, J., Flockerzi, V. & Alexander, R. T., 2019, In : Cellular and Molecular Gastroenterology and Hepatology. 8, 4, p. 625-642

Research output: Contribution to journalJournal articleResearchpeer-review

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2018

Axial and Cellular Heterogeneity in Electrolyte Transport Pathways Along the Thick Ascending Limb

Dimke, H. & Schnermann, J., May 2018, In : Acta Physiologica (Print). 223, 1, 17 p., e13057.

Research output: Contribution to journalJournal articleResearchpeer-review

Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Krishnan, D., Pan, W., Beggs, M. R., Trepiccione, F., Chambrey, R., Eladari, D., Cordat, E., Dimke, H. & Alexander, R. T., 2018, In : Frontiers in Physiology. 8, 12 p., 1108.

Research output: Contribution to journalJournal articleResearchpeer-review

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Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

Laursen, S. B., Finsen, S., Marcussen, N., Quaggin, S. E., Hansen, P. B. L. & Dimke, H., 1. Feb 2018, In : PLOS ONE. 13, 2, 20 p., e0193032.

Research output: Contribution to journalJournal articleResearchpeer-review

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H +-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney

Frische, S., Chambrey, R., Trepiccione, F., Zamani, R., Marcussen, N., Alexander, R. T., Skjødt, K., Svenningsen, P. & Dimke, H., 1. Sep 2018, In : American Journal of Physiology: Renal Physiology. 315, 3, p. F429-F444

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Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney

Zachar, R., Al-Mashhadi, A., Dimke, H., Svenningsen, P., Jensen, B. L. & Carlström, M., 1. Sep 2018, In : American Journal of Physiology: Renal Physiology. 315, 3, p. F547-F557

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2017

A variant in a Cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones

Ure, M. E., Heydari, E., Pan, W., Ramesh, A., Rehman, S., Morgan, C., Pinsk, M., Erickson, R., Herrmann, J. M., Dimke, H., Cordat, E., Lemaire, M., Walter, M. & Alexander, R. T., Jun 2017, In : Human Mutation. 38, 6, p. 649–657

Research output: Contribution to journalJournal articleResearchpeer-review

Effect of Diuretics on Renal Tubular Transport of Calcium and Magnesium

Alexander, R. T. & Dimke, H., 1. Jun 2017, In : American Journal of Physiology: Renal Physiology. 312, 6, p. F998-F1015

Research output: Contribution to journalJournal articleResearchpeer-review

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Effects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule: [version 1; referees: 2 approved]

Lee, J. J., Plain, A., Beggs, M. R., Dimke, H. & Alexander, R. T., 2017, In : F1000Research. 6, 14 p., 1797.

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Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation

Beggs, M. R., Appel, I., Svenningsen, P., Skjødt, K., Alexander, T. R. & Dimke, H., 1. Sep 2017, In : American Journal of Physiology: Renal Physiology. 313, 3, p. F629-F640

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2016

Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders

Alexander, R. T., Cordat, E., Chambrey, R., Dimke, H. & Eladari, D., Dec 2016, In : American Society of Nephrology. Journal. 27, 12, p. 3511-3520

Research output: Contribution to journalJournal articleResearchpeer-review

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling

Tutakhel, O. A. Z., Jeleń, S., Valdez-Flores, M., Dimke, H., Piersma, S. R., Jimenez, C. R., Deinum, J., Lenders, J. W., Hoenderop, J. G. J. & Bindels, R. J. M., 1. Feb 2016, In : American Journal of Physiology: Renal Physiology. 310, 3, p. F204-F216

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Untargeted metabolomics analysis of ABCC6-deficient mice discloses an altered metabolic liver profile

Rasmussen, M. R., Nielsen, K. L., Laursen, M. R., Nielsen, C. B., Svendsen, P., Dimke, H., Christensen, E. I., Johannsen, M. & Moestrup, S. K., 19. Oct 2016, In : Journal of Proteome Research. 15, 12, p. 4591-4600

Research output: Contribution to journalJournal articleResearchpeer-review

2015

A single simple procedure for dewaxing, hydration and heat-induced epitope retrieval (HIER) for immunohistochemistry in formalin fixed paraffin-embedded tissue

Paulsen, I. M. S., Dimke, H. & Frische, S., 3. Nov 2015, In : European Journal of Histochemistry. 59, 4, p. 303-309 2532.

Research output: Contribution to journalJournal articleResearchpeer-review

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Crosstalk in glomerular injury and repair

Dimke, H., Maezawa, Y. & Quaggin, S. E., May 2015, In : Current Opinion in Nephrology & Hypertension. 24, 3, p. 231–238

Research output: Contribution to journalJournal articleResearchpeer-review

Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney

Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M. & Quaggin, S. E., May 2015, In : Journal of the American Society of Nephrology. 26, 5, p. 1027-1038

Research output: Contribution to journalJournal articleResearchpeer-review

Ultrastructural and immunohistochemical localization of plasma membrane Ca 2+-ATPase 4 in Ca 2+-transporting epithelia

Alexander, R. T., Beggs, M. R., Zamani, R., Marcussen, N., Frische, S. & Dimke, H., 1. Oct 2015, In : American Journal of Physiology: Renal Physiology. 309, 7, p. F604-F616 ajprenal.00651.2014.

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling

San-Cristobal, P., Lainez, S., Dimke, H., de Graaf, M. J. J., Hoenderop, J. G. J. & Bindels, R. J. M., 2014, In : Kidney International. 85, 1, p. 94-102

Research output: Contribution to journalJournal articleResearchpeer-review

Loss of the Podocyte-Expressed Transcription Factor Tcf21/Pod1 Results in Podocyte Differentiation Defects and FSGS

Maezawa, Y., Onay, T., Scott, R. P., Keir, L. S., Dimke, H., Li, C., Eremina, V., Maezawa, Y., Jeansson, M., Shan, J., Binnie, M., Lewin, M., Ghosh, A., Miner, J. H., Vainio, S. J. & Quaggin, S. E., 5. Jun 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2459-2470

Research output: Contribution to journalJournal articleResearchpeer-review

Paracellular calcium transport across renal and intestinal epithelia

Alexander, R. T., Rievaj, J. & Dimke, H., 2014, In : Biochemistry and Cell Biology. 92, 6, p. 467-480

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Activation of the Ca(2+)-sensing receptor increases renal claudin-14 expression and urinary Ca(2+) excretion

Dimke, H., Desai, P., Borovac, J., Lau, A., Pan, W. & Alexander, R. T., 15. Mar 2013, In : American Journal of Physiology: Renal Physiology. 304, 6, p. F761-9

Research output: Contribution to journalJournal articleResearchpeer-review

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5

Loh, N. Y., Bentley, L., Dimke, H., Verkaart, S., Tammaro, P., Gorvin, C. M., Stechman, M. J., Ahmad, B. N., Hannan, F. M., Piret, S. E., Evans, H., Bellantuono, I., Hough, T. A., Fraser, W. D., Hoenderop, J. G. J., Ashcroft, F. M., Brown, S. D. M., Bindels, R. J. M., Cox, R. D. & Thakker, R. V., 2013, In : PLOS ONE. 8, 1, p. e55412

Research output: Contribution to journalJournal articleResearchpeer-review

Evaluation of hypomagnesemia: lessons from disorders of tubular transport

Dimke, H., Monnens, L., Hoenderop, J. G. J. & Bindels, R. J. M., Aug 2013, In : Monografi: ISSN 1046-7750. 62, 2, p. 377-83 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Proximal tubular NHEs: sodium, protons and calcium?

Alexander, R. T., Dimke, H. & Cordat, E., 1. Aug 2013, In : American Journal of Physiology: Renal Physiology. 305, 3, p. F229-36

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner

Boros, S., Xi, Q., Dimke, H., van der Kemp, A. W., Tudpor, K., Verkaart, S., Lee, K. P., Bindels, R. J. & Hoenderop, J. G., 2012, In : Monografi: ISSN 1046-7750. 69, 6, p. 981-92

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC)

Dimke, H., Dec 2011, In : Pflügers Archiv - European Journal of Physiology. 462, 6, p. 767-77

Research output: Contribution to journalJournal articleResearchpeer-review

Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family

Dimke, H., Hoenderop, J. G. J. & Bindels, R. J. M., 1. Apr 2011, In : Journal of Physiology. 589, Pt 7, p. 1535-42

Research output: Contribution to journalJournal articleResearchpeer-review

Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats

O'Neill, H. A., Kwon, T-H., Ring, T., Dimke, H., Lebeck, J., Frøkiaer, J., Collins, P. B., Nielsen, S. & Frische, S., May 2011, In : Acta Physiologica (Print). 202, 1, p. 47-57

Research output: Contribution to journalJournal articleResearchpeer-review

γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter

Dimke, H., San-Cristobal, P., de Graaf, M., Lenders, J. W., Deinum, J., Hoenderop, J. G. J. & Bindels, R. J. M., Mar 2011, In : Journal of the American Society of Nephrology. 22, 3, p. 508-17 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5

Hsu, Y-J., Dimke, H., Hoenderop, J. G. J. & Bindels, R. J. M., May 2010, In : Nephrology, Dialysis, Transplantation. 25, 5, p. 1428-35

Research output: Contribution to journalJournal articleResearchpeer-review

Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling

Dimke, H., van der Wijst, J., Alexander, T. R., Meijer, I. M. J., Mulder, G. M., van Goor, H., Tejpar, S., Hoenderop, J. G. & Bindels, R. J., Aug 2010, In : Journal of the American Society of Nephrology. 21, 8, p. 1309-16

Research output: Contribution to journalJournal articleResearchpeer-review

Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+

Dimke, H., Hoenderop, J. G. & Bindels, R. J., Jan 2010, In : Monografi: ISSN 1046-7750. 118, 1, 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Novel molecular pathways in renal Mg2+ transport: a guided tour along the nephron

San-Cristobal, P., Dimke, H., Hoenderop, J. G. & Bindels, R. J., Sep 2010, In : Current Opinion in Nephrology & Hypertension. 19, 5, p. 456-62

Research output: Contribution to journalJournal articleResearchpeer-review

Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins

Hsu, Y-J., Dimke, H., Schoeber, J. P. H., Hsu, S-C., Lin, S-H., Chu, P., Hoenderop, J. G. J. & Bindels, R. J. M., Apr 2010, In : Kidney International. Supplement. 77, 7, p. 601-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2007

Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2

Dimke, H., Flyvbjerg, A., Bourgeois, S., Thomsen, K., Frøkiaer, J., Houillier, P., Nielsen, S. & Frische, S., 2007, In : American Journal of Physiology: Renal Physiology. 292, 2, p. F723-35

Research output: Contribution to journalJournal articleResearchpeer-review

Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney

de Seigneux, S., Nielsen, J., Olesen, E. T. B., Dimke, H., Kwon, T-H., Frøkiaer, J. & Nielsen, S., Jul 2007, In : American Journal of Physiology: Renal Physiology. 293, 1, p. F87-99

Research output: Contribution to journalJournal articleResearchpeer-review

Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule

de Seigneux, S., Malte, H., Dimke, H., Frøkiaer, J., Nielsen, S. & Frische, S., Apr 2007, In : American Journal of Physiology: Renal Physiology. 292, 4, p. F1256-66

Research output: Contribution to journalJournal articleResearchpeer-review