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Research Output

2020

Cardiomyocyte Proteome Remodeling due to Isoproterenol-Induced Cardiac Hypertrophy during the Compensated Phase

Parreira, R. C., Gómez-Mendoza, D. P., de Jesus, I. C. G., Lemos, R. P., Santos, A. K., Rezende, C. P., Figueiredo, H. C. P., Pinto, M. C. X., Kjeldsen, F., Guatimosim, S., Resende, R. R. & Verano-Braga, T., Jul 2020, In : Proteomics - Clinical Applications. 14, 4, 12 p., 2000017.

Research output: Contribution to journalJournal articleResearchpeer-review

DirectMS1: MS/MS-free identification of 1000 proteins of cellular proteomes in 5 minutes

Ivanov, M. V., Bubis, J. A., Gorshkov, V. A., Tarasova, I. A., Levitsky, L. I., Lobas, A. A., Solovyeva, E. M., Pridatchenko, M. L., Kjeldsen, F. & Gorshkov, M. V., Mar 2020, In : Analytical chemistry. 92, 6, p. 4326-4333

Research output: Contribution to journalJournal articleResearchpeer-review

Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles

Billing, A. M., Knudsen, K. B., Chetwynd, A. J., Ellis, L-J. A., Tang, S. V. Y., Berthing, T., Wallin, H., Lynch, I., Vogel, U. & Kjeldsen, F., 2020, In : ACS Nano. 14, 4, p. 4096-4110

Research output: Contribution to journalJournal articleResearchpeer-review

GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels

Montandon, G. G., Cassoli, J. S., Peigneur, S., Braga, T. V., Moreira Dos Santos, D., Bittencourt Paiva, A. L., Ricardo de Moraes, É., Kushmerick, C., Borges, M. H., Richardson, M., Monteiro de Castro Pimenta, A., Kjeldsen, F., Vasconcelos Diniz, M. R., Tytgat, J. & Elena de Lima, M., Sep 2020, In : Biochimie. 176, p. 138-149

Research output: Contribution to journalJournal articleResearchpeer-review

HUMOS: How to Understand My Orbitrap Spectrum? - An interactive web-based tool to teach the basics of mass spectrometry-based proteomics

Bubis, J. A., Gorshkov, V., Billing, A. M. & Kjeldsen, F., 2020, In : Journal of proteome research. 19, 10, p. 3910-3918

Research output: Contribution to journalJournal articleResearchpeer-review

Moving pieces in a cellular puzzle: a cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban

Gómez-Mendoza, D. P., Lemos, R. P., Jesus, I., Gorshkov, V., McKinnie, S. M. K., Vederas, J. C., Kjeldsen, F., Guatimosim, S., Santos, R. A., Pimenta, A. M. C. & Verano-Braga, T., 7. Aug 2020, In : Journal of proteome research. 19, 8, p. 3467-3477

Research output: Contribution to journalJournal articleResearchpeer-review

PhosphoShield: Improving Trypsin Digestion of Phosphoproteins by Shielding the Negatively Charged Phosphate Moiety

Bubis, J. A., Gorshkov, V., Gorshkov, M. V. & Kjeldsen, F., 25. Aug 2020, In : Journal of The American Society for Mass Spectrometry.

Research output: Contribution to journalJournal articleResearchpeer-review

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Proteomic and phosphoproteomic analyses in HL60 cells treated with the scorpion-derived peptide Lunatin-1

Lima-Batista, E. M., Gómez-Mendoza, D. P., Moysés, M. N., de Sousa Gomes, K., de Lima, M. E., Souza-Fagundes, E. M., da Silva, A. M., Kjeldsen, F., Verano-Braga, T. & Pimenta, A. M. C., 20. Apr 2020, In : Toxicon. 177 , Suppl. 1, p. S39 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Rpn4 and proteasome-mediated yeast resistance to ethanol includes regulation of autophagy

Bubis, J. A., Spasskaya, D. S., Gorshkov, V. A., Kjeldsen, F., Kofanova, A. M., Lekanov, D. S., Gorshkov, M. V., Karpov, V. L., Tarasova, I. A. & Karpov, D. S., 2020, In : Applied Microbiology and Biotechnology. 104, 9, p. 4027-4041

Research output: Contribution to journalJournal articleResearchpeer-review

The Cytotoxicity of Metal Nanoparticles Depends on Their Synergistic Interactions

Korzeniowska, B., Fonseca, M. P., Gorshkov, V., Skytte, L., Rasmussen, K. L., Schrøder, H. D. & Kjeldsen, F., 1. Aug 2020, In : Particle and Particle Systems Characterization. 37, 8, 2000135.

Research output: Contribution to journalJournal articleResearchpeer-review

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29 Downloads (Pure)
2019

Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4

Gómez-Mendoza, D. P., Marques, F. D., Melo-Braga, M. N., Sprenger, R. R., Sinisterra, R. D., Kjeldsen, F., Santos, R. A. & Verano-Braga, T., 30. Sep 2019, In : Journal of Proteomics. 208, 11 p., 103486.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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9 Downloads (Pure)

Assessment of protein extraction and digestion efficiency of well-established shotgun protocols for heart proteomics

Rodrigues-Ribeiro, L., Melo-Braga, M. N., Kjeldsen, F., Gómez-Mendoza, D. P. & Verano-Braga, T., 1. Aug 2019, In : Analytical Biochemistry. 578, p. 51-59

Research output: Contribution to journalJournal articleResearchpeer-review

DirectMS1: MS/MS-free identification of 1000 proteins of cellular proteomes in 5 minutes

Ivanov, M. V., Bubis, J. A., Gorshkov, V., Tarasova, I. A., Levitsky, L. I., Lobas, A. A., Solovyeva, E. M., Pridatchenko, M. L., Kjeldsen, F. & Gorshkov, M. V., 5. Sep 2019, In : BioRxiv. 17 p.

Research output: Contribution to journalJournal articleResearch

Open Access

Five-Minute Proteome: An MS/MS-Free Approach to Protein Identification and Quantification

Ivanov, V., Bubis, J. A., Gorshkov, V., Tarasova, I. A., Solovyeva, E. M., Levitsky, L. I., Lobas, A. A., Pridatchenko, M. L., Kjeldsen, F. & Gorshkov, M. V., 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Neutrophil Extracellular Trap Formation in the Lung as Response to Magnetic Cobalt Ferrite Nanoparticles

Billing, A. M., Knudsen, K. B., Wallin, H., Tang, S. VY., Lynch, I., Vogel, U. & Kjeldsen, F., 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides

Gonzalez-Pizarro, R., Parrotta, G., Vera, R., Sánchez-López, E., Galindo, R., Kjeldsen, F., Badia, J., Baldoma, L., Espina, M. & García, M. L., 2019, In : Nanomedicine. 14, 23, p. 3089-3104 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution

Gorshkov, V., Bubis, J. A., Solovyeva, E. M., Gorshkov, M. V. & Kjeldsen, F., 18. Mar 2019, In : Environmental Science: Nano. 6, 4, p. 1089-1098

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
166 Downloads (Pure)

Searching for the Ethanol-Tolerant Yeast: Rpn4- and Proteasome-Dependent Yeast Proteome Remodeling in Response to Ethanol Stress

Bubis, J. A., Tarasova, I. A., Gorshkov, V., Karpov, V. L., Spasskaya, D. S., Kjeldsen, F., Gorshkov, M. V. & Karpov, D. S., 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Khan, A. M., Korzeniowska, B., Gorshkov, V., Tahir, M., Schrøder, H., Skytte, L., Rasmussen, K. L., Khandige, S., Møller-Jensen, J. & Kjeldsen, F., 9. Jan 2019, In : Nanotoxicology. 13, 2, p. 221-239

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
190 Downloads (Pure)
2018

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells

Miranda, R. R., Gorshkov, V., Korzeniowska, B., Kempf, S. J., Neto, F. F. & Kjeldsen, F., 11. Jul 2018, In : Nanotoxicology. 12, 7, p. 781-795

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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153 Downloads (Pure)

Co-exposure to silver nanoparticles and cadmium ions induces metabolic adaptation in HepG2 cells

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Comparative proteomics as a tool for identifying specific alterations within interferon response pathways in human glioblastoma multiforme cells

Tarasova, I. A., Tereshkova, A. V., Lobas, A. A., Solovyeva, E. M., Sidorenko, A. S., Gorshkov, V., Kjeldsen, F., Bubis, J. A., Ivanov, M. V., Ilina, I. Y., Moshkovskii, S. A., Chumakov, P. M. & Gorshkov, M. V., 1. Jan 2018, In : OncoTarget. 9, 2, p. 1785-1802

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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210 Downloads (Pure)

Comparative proteomics study for elucidation of potential mechanisms underlying yeast resistance to alcohols

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

LC-MS/MS-based characterization of glioblastoma cell responses to type I interferons for establishing defects in antiviral mechanisms

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Perturbation of Protein Conformation has Minor Impact on Nanoparticle Corona Composition

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Proteome profiling of bronchioalveolar lavage fluid after exposure to magnetic iron and cobalt oxide nanoparticles

Kjeldsen, F., 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Open Access
File
262 Downloads (Pure)
2017

Co-exposure of silver nanoparticles and Cd2+ induce disruption of the metabolic reprogramming in HepG2 cells

Kjeldsen, F., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

On the Authenticity of a Relic: An Archaeometric Investigation of the Supposed Bread Sack of Saint Francesco of Assisi

Rasmussen, K. L., Degano, I., Colombini, M. P., Kjeldsen, F. & van der Plicht, J., 2017, In : Radiocarbon: An International Journal of Cosmogenic Isotope Research. 59, 5, p. 1425-1433

Research output: Contribution to journalConference articleResearchpeer-review

Toxicological interactions of silver nanoparticles and non-essential metals in human hepatocarcinoma cell line

Miranda, R. R., Bezerra, A. G., Ribeiro, C. A. O., Randi, M. A. F., Voigt, C. L., Skytte, L., Rasmussen, K. L., Kjeldsen, F. & Neto, F. F., 2017, In : Toxicology in Vitro. 40, p. 134–143

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products

Elnegaard, R. L. B., Møllegaard, N. E., Zhang, Q., Kjeldsen, F. & Jørgensen, T. J. D., 2017, In : ChemBioChem. 18, 12, p. 1117-1122

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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162 Downloads (Pure)
2016

High-performance hybrid Orbitrap mass spectrometers for quantitative proteome analysis: Observations and implications

Williamson, J. C., Edwards, A. V. G., Verano-Braga, T., Schwämmle, V., Kjeldsen, F., Jensen, O. N. & Larsen, M. R., Mar 2016, In : Proteomics. 16, 6, p. 907-914

Research output: Contribution to journalJournal articleResearchpeer-review

Peptide de novo sequencing of mixture tandem mass spectra

Gorshkov, V., Hotta, S. Y. K., Braga, T. V. & Kjeldsen, F., 19. Sep 2016, In : Proteomics. 16, 18, p. 2470-2479

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
256 Downloads (Pure)
2015

Charge Inversion of Phospholipids by Dimetal Complexes for Positive Ion-Mode Electrospray Ionization Mass Spectrometry Analysis

Svane, S., Gorshkov, V. & Kjeldsen, F., 1. Sep 2015, In : Analytical Chemistry. 87, 17, p. 8732-8739

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
183 Downloads (Pure)

Effect of Metals in Biomimetic Dimetal Complexes on Affinity and Gas-Phase Protection of Phosphate Esters

Svane, S., Jørgensen, T. J. D., McKenzie, C. & Kjeldsen, F., 2015, In : Analytical Chemistry. 87, 14, p. 7060–7068

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
198 Downloads (Pure)

Extending the Quantitative Information of the Glioblastoma Proteome Using SuperQuant

Kjeldsen, F., 28. Sep 2015.

Research output: Contribution to conference without publisher/journalPosterResearch

SuperQuant: a Data Processing Approach to Increase Quantitative Proteome Coverage

Gorshkov, V., Verano-Braga, T. & Kjeldsen, F., 15. May 2015, In : Analytical Chemistry. 87, 12, p. 6319–6327

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
191 Downloads (Pure)

The Selectivity of Water-based Pyrophosphate Recognition is Tuned by Metal Substitution in Dimetallic Receptors

Svane, S., Kjeldsen, F., McKee, V. & McKenzie, C., 2015, In : Dalton Transactions (Print Edition). 44, 26, p. 11877-11886

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

Miethling-Graff, R., Rumpker, R., Richter, M., Verano-Braga, T., Kjeldsen, F., Brewer, J. R., Hoyland, J., Rubahn, H-G. & Erdmann, H., 2014, In : Toxicology in Vitro. 28, 7, p. 1280–1289

Research output: Contribution to journalJournal articleResearchpeer-review

Insights into the Cellular Response Triggered by Silver Nanoparticles using Quantitative Proteomics

Verano-Braga, T., Miethling-Graff, R., Wojdyla, K. I., Rogowska-Wrzesinska, A., Brewer, J. R., Erdmann, H. & Kjeldsen, F., 2014, In : A C S Nano. 8, 3, p. 2161–2175

Research output: Contribution to journalJournal articleResearchpeer-review

N-terminal sequence tagging using reliably determined b2 ions: A useful approach to deconvolute tandem mass spectra of co-fragmented peptides in proteomics

Kryuchkov, F., Verano-Braga, T. & Kjeldsen, F., 2014, In : Journal of Proteomics. 103, May, p. 254–260

Research output: Contribution to journalJournal articleResearchpeer-review

Q-Exactive Plus and Orbitrap Fusion: Determination of optimal settings for peptide and phosphopeptide identification

Verano-Braga, T., Williamson, J., Edwards, A., Jensen, O. N., Kjeldsen, F. & Larsen, M. R., 2014.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Qualitative and Quantitative Comparison of Q Exactive Plus and Orbitrap Fusion for Label Free and Isobaric Tag Based Quantification

Williamson, J., Verano-Braga, T., Edwards, A., Kjeldsen, F., Larsen, M. R. & Jensen, O. N., 2014.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2013

Application of complementary ions to identify co-isolated peptides in complex samples

Kjeldsen, F., Hansen, T. A., Verano-Braga, T., Sprenger, R. R. & Kryuchkov, F., 12. Jun 2013.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Deconvolution of mixture spectra and increased throughput of Peptide identification by utilization of intensified complementary ions formed in tandem mass spectrometry

Kryuchkov, F., Verano-Braga, T., Hansen, T. A., Sprenger, R. R. & Kjeldsen, F., 3. Jun 2013, In : Journal of Proteome Research. 12, 7, p. 3362–3371

Research output: Contribution to journalJournal articleResearchpeer-review

DIMETALLIC PROTECTING GROUP FOR PHOSPHORYLATED PEPTIDES AND PROTEINS

McKenzie, Christine, J., Kjeldsen, F. & Svane, S., 10. May 2013, IPC No. G01N 33/ 68 A I, Patent No. WO2013064554, Priority date 30. Apr 2012, Priority No. DK2012PA00290

Research output: Patent

Dimetal Phosphate Ester Stabilization and Strong-Cation Exchange Chromatography (DIMPES-SCX): A Novel Approach for Phosphopeptide Enrichment

Verano-Braga, T., Svane, S., McKenzie, C. J. & Kjeldsen, F., 12. Jun 2013.

Research output: Contribution to conference without publisher/journalPosterResearch

Discovery and Characterization of Alamandine, a Novel Component of the Renin-Angiotensin System

Lautner, R. Q., Villela, D. C., Fraga-Silva, R. A., Silva, N. C., Verano-Braga, T., Costa-Fraga, F., Jankowski, J., Jankowski, V., De Sousa, F. B., Alzamora, A. C., Soares, E. R., Barbosa, C. M., Kjeldsen, F., Oliveira, A. C., Braga, J. F., Savergnini, S. Q., Etelvino, G. M., Peluso, A. A. B., Passos-Silva, D. G., Ferreira, A. J. & 12 others, Alves, F., Martins, A. S., Raizada, M. K., Paula, R. D., Motta-Santos, D., Klempin, F., Pimenta, A. M. C., Alenina, N., Sinisterra, R. D. M., Bader, M., Campagnole-Santos, M. J. & Santos, R. A., 2013, In : Circulation Research. 112, 8, p. 1104-1111 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review