Research areas

Brain tumor, drug delivery, brain tumor animal models, translational research, clinical research

Research information

Hjernetumorer, translationel forskning, klinisk forskning

Curriculum

CURRICULUM VITAE PHD, MD Bo Halle

PROFILE 
-Junior Consultant Neurosurgery, Associate Professor, MD, PhD
-Board member, Danish Neurosurgical Society (2014-2019)
-Member of the Danish Brain Cancer Society Expert Panel (2017-)
-Research focus: Brain tumor models, Brain cancer, Skull base tumors, Drug-delivery, Convection-enhanced delivery
-18 publications

EDUCATION
2018 Specialist in Neurosurgery
2014 PhD, Univ. of Southern Denmark
2006 Medical Doctor (MD), Univ. of Southern Denmark

SCIENTIFIC ACTIVITIES

SCIENTIFIC POSITIONS
2018, Associate Professor, Clinical Institute, Univ. of Southern Denmark
2011-2014, PhD student, Faculty of Health Sciences, Univ. of Southern Denmark

SUPERVISION OF STUDENTS (Co supervisor)
-One-year pre-graduate medical research stud: 3

INTERNATIONAL COLLABORATIONS
-E Marcusson, PhD, Regulus Therapeutics, Inc. 3545 John Hopkins Ct., Suite 210, San Diego, CA 92121-1121, USA
-N Barua, MD, PhD, Consultant Neurosurgeon / Research Fellow, Neuro-oncology and Functional Neurosurgery Southmead Hospital/University of Bristol, UK
-Renishaw Plc., Gloucester, United Kingdom

AWARDS
2016, Alavi-Mandell Award
2015, First prize, Annual oral presentation competition, Spring meeting Danish Neurosurgical Society
2014, Second prize, Annual oral presentation competition, Spring meeting Danish Neurosurgical Society
2006, Prize from the Danish Arthritis Foundation Research Council

TEACHING ACTIVITIES
1995-2004, Teaching soldiers in the Danish Armed Forces. From 1997-2004 as an officer.
1999-2006, Teaching Med. Students in traumatology and acute medicine. Approx. 300 hours.
2006-, Teaching Med. Students in the everyday clinic, in neurosurgical topics as both Problem Based Learning sessions as well as formal lectures.

OTHER ACTIVITIES
2014, Chairman, Kongres for Medicinsk Studenterforskning
Several invited talks on neurosurgery in student associations, patient associations and scientific societies

2019, DRP1 Hjernekassen, emne hjernetumorer

GRANTS
2017, 200,000 Dkr from The Danish Cancer Society
2017, 600,000 Dkr from the Region of Southern Denmark
2016, 12,000 Dkr from Overlægerådets Forskningsfond
2012, 35,000 Dkr from AJ Andersen og Hustrus Fond
2012, 25,000 Dkr from Grosserer M Brogaard og Hustrus Mindefond
2012, 175,000 Dkr from Dansk Kræftforskningsfond
2011, 60,000 Dkr from AJ Andersen og Hustrus Fond
2011, 25,000 Dkr from Direktør Kurt Bønnelycke og hustru fru Grethr Bønnelyckes Fond
2011, 12,000 Dkr from Lægernes Forsikringsforening af 1891

PATENTS
Auger electron therapy for glioblastoma (EP14173218.0)

Publications
Total number of publications: 18
Total number of Senior author publications: 1
Total number of 1. author publications: 6
Total number of shared 1. author publications: 1
H-index 7

PUBLICATION LIST

Winkler Møller, M., Skovsager Andersen, M., Glintborg, D., Pedersen, C. B., & Halle, B. (2019). Hypofyseadenom. Ugeskrift for Laeger, 181(10), PMID: 31124446

Andersen, M. C. S., Pedersen, C. B., Mathiesen, T. I., Poulsgaard, L., Kristensen, B. W., Halle, B., & Rom Poulsen, F. (2019). Intrakraniale meningeomer. Ugeskrift for Laeger, 181(10), PMID: 30722833

Halle B, Mongelard K, Poulsen FR. Convection-enhanced Drug Delivery for Glioblastoma: A Systematic Review Focused on Methodological Differences in the Use of the Convection-enhanced Delivery Method. Asian J Neurosurg 2019 Jan-Mar;14(1):5-14, PMID: 30937002

Aaberg-Jessen C, Fogh L, Sørensen MD, Halle B, Brünner N, Kristensen BW. Overexpression of TIMP-1 and Sensitivity to Topoisomerase Inhibitors in Glioblastoma Cell Lines. Pathol Oncol Res. 2017 Sep 30. PMID: 28962609

Jensen SS, Petterson SA, Halle B, Aaberg-Jessen C, Kristensen BW. Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo. BMC Cancer. 2017 Mar 7;17(1):178. PMID: 28270132

Munthe S, Halle B, Boldt HB, Christiansen H, Schmidt S, Kaimal V, et al. Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions. J Neurooncol. 2017 Mar;(132(1):45-54. PMID: 28091986

Gaist D, Garcia Rodriguez LA, Hellfritzsch M, Poulsen FR, Halle B, Hallas J, Pottegård A. Association of Antithrombotic Drug Use With Subdural Hematoma Risk. JAMA 2017 Feb 28;317(8):836-846. PMID: 28245322

Aaberg-Jessen C, Halle B, Jensen SS, Muller S, Romer UM, Pedersen CB, et al. Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients. J Neurooncol. 2016 Dec;130(3):439-48. PMID: 27619981

Poulsen FR, Halle B, Pottegård A, García Rodríguez LA, Hallas J, Gaist D. Subdural hematoma cases identified through a Danish patient register: diagnosis validity, clinical characteristics, and preadmission antithrombotic drug use. Pharmacoepidemiol Drug Saf. 2016 Nov;25(11):1253-1262. PMID: 27384945

Thisgaard H*, Halle B*, Aaberg-Jessen C, Olsen BB, Therkelsen ASN, Dam JH, et al. Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery. Theranostics. 2016;6(12):2278-91. (*Shared first authorship). PMID: 27924163

Halle B, Thomassen M, Venkatesan R, Kaimal V, Marcusson EG, Munthe S, et al. Shift of microRNA profile upon orthotopic xenografting of glioblastoma spheroid cultures. J Neurooncol. 2016 Jul;128(3):395-404. PMID: 27063952

Jensen SS, Meyer M, Petterson SA, Halle B, Rosager AM, Aaberg-Jessen C, Thomassen M, Burton M, Kruse TA, Kristensen BW. Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model. PLoS One. 2016 Jul 25;11(7). PMID: 27454178

Petterson SA, Jakobsen IP, Jensen SS, Aaberg-Jessen C, Halle B, Nielsen M, Halle DM, Johansen J, Kristensen BW. Short-term effects of radiation in glioblastoma spheroids. Int J Clin Exp Pathol 2016;9(2):576-588.

Halle B, Marcusson EG, Aaberg-Jessen C, Jensen SS, Meyer M, Schulz MK, et al. Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept. J Neurooncol. 2016 Jan;126(1):47-55. PMID: 26428358

Halle B, Thisgaard H, Hvidsten S, Dam JH, Aaberg-Jessen C, Thykjaer AS, et al. Estimation of Tumor Volumes by C-11-MeAIB and F-18-FDG PET in an Orthotopic Glioblastoma Rat Model. Journal of Nuclear Medicine. 2015 Oct;56(10):1562-8. PMID: 26229144

Poulsen FR, Munthe S, Soe M, Halle B. Perindopril and residual chronic subdural hematoma volumes six weeks after burr hole surgery: A randomized trial. Clin Neurol Neurosurg. 2014 Aug;123:4-8. PMID: 25012003

Halle B, Andersen C, Schulz MK, Kristensen BW. New glioma therapy using specific microRNAs. Ugeskr Laeger. 2012 Mar 5;174(10):630-3. PMID: 22395010

Halle B, Halle DM, Torfing T, Overgaard S. The role of acetabulum geometry and femoral head-neck ratio in the development of osteoarthritis in young men. Hip Int. 2007 Jul-Sep;17(3):131-6. PMID: 19197857