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Research Output 2004 2020

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Journal article
2020

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

Madsen, P. M., Desu, H. L., Pablo de Rivero Vaccari, J., Florimon, Y., Ellman, D. G., Keane, R. W., Clausen, B. H., Lambertsen, K. L. & Brambilla, R., Feb 2020, In : Brain, Behavior, and Immunity. 84, p. 132-146

Research output: Contribution to journalJournal articleResearchpeer-review

Receptors, Tumor Necrosis Factor, Type II
Autoimmune Experimental Encephalomyelitis
Oligodendroglia
Receptors, Tumor Necrosis Factor, Type I
Membranes
2019

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15. May 2019, In : Neuropharmacology. 150, p. 100-111

Research output: Contribution to journalJournal articleResearchpeer-review

N-Methyl-D-Aspartate Receptors
Arterial Pressure
Fluorescence Polarization
Middle Cerebral Artery Infarction
Rodentia
66 Downloads (Pure)

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

Yli-Karjanmaa, M. L. K., Clausen, B. H., Degn, M., Novrup, H. G., Ellman, D. G., jensen, P. T., Szymkowski, D. E., Stensballe, A., Meyer, M., Brambilla, R. & Lambertsen, K. L., Aug 2019, In : Frontiers in Neuroscience. 13, JUL, 18 p., 781.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Middle Cerebral Artery Infarction
Tumor Necrosis Factor-alpha
XENP 1595
Population
Etanercept
2018
105 Downloads (Pure)

Distal middle cerebral artery occlusion does not result in depression-like behaviours

Couch, Y., Clausen, B. H., Ormhøj, M., Andersen, M. G., Nygaard, C. K., Møller-Nielsen, M. & Lambertsen, K. L., 7. Sep 2018, In : F1000Research. 12 p., 1430.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
144 Downloads (Pure)

Inflammation leads to distinct populations of extracellular vesicles from microglia

Yang, Y., Boza-Serrano, A., Dunning, C. J. R., Clausen, B. H., Lambertsen, K. L. & Deierborg, T., 28. May 2018, In : Journal of Neuroinflammation. 15, 19 p., 168.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Population
Tumor Necrosis Factor-alpha
Proteins
Cell Communication
2017

Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke

Grønhøj, M. B., Clausen, B. H., Fenger, C., Lambertsen, K. L. & Finsen, B., Oct 2017, In : Brain, Behavior, and Immunity. 65, p. 296-311

Research output: Contribution to journalJournal articleResearchpeer-review

Interleukin-6
Middle Cerebral Artery Infarction
Interleukin-6 Receptors
Messenger RNA
Therapeutic Uses
154 Downloads (Pure)

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Venø, M. T., Venø, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J., 2017, In : Frontiers in Molecular Neuroscience. 10, 10 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
MicroRNAs
Morphogenesis
Embryonic Structures
Neurons

Fumarate decreases edema volume and improves functional outcome after experimental stroke

Clausen, B. H., Lundberg, L., Yli-Karjanmaa, M. L. K., Martin, N. A., Svensson, M., Zeiler Alfsen, M., Flæng, S. B., Lyngsø, K. S., Boza-Serrano, A., Nielsen, H. H., Hansen, P. B. L., Finsen, B., Deierborg, T., Illés, Z. & Lambertsen, K. L., Sep 2017, In : Experimental Neurology. 295, p. 144–154

Research output: Contribution to journalJournal articleResearchpeer-review

Middle Cerebral Artery Infarction
HSP72 Heat-Shock Proteins
Interleukin-10
Erythroid Cells
Proteins
278 Downloads (Pure)

Spontaneous ischaemic stroke lesions in a dog brain: Neuropathological characterisation and comparison to human ischaemic stroke

Thomsen, B. B., Gredal, H., Nielsen, M. W., Kristensen, B. W., Clausen, B. H., larsen, A. E., Finsen, B., Berendt, M. & Lambertsen, K. L., 13. Jan 2017, In : Acta Veterinaria Scandinavica (Online Edition). 59, 9 p., 7.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
stroke
lesions (animal)
Dogs
brain
dogs
2016

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thöne-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlöf, B., Hallberg, A., Unger, T. & Steckelings, U. M., 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966

Research output: Contribution to journalJournal articleResearchpeer-review

Angiotensin Type 2 Receptor
Middle Cerebral Artery Infarction
Brain-Derived Neurotrophic Factor
GAP-43 Protein
trkB Receptor

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Deierborg, T. & Finsen, B., 2016, In : Acta Neuropathologica. 131, 5, p. 775-91

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Interleukin-1 Receptors
Microglia
Neuroprotective Agents
132 Downloads (Pure)

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Clausen, B. H., Degn, M., Sivasaravanaparan, M., Fogtmann, T., Andersen, M. G., Trojanowsky, M. D., Gao, H., Hvidsten, S., Baun, C., Deierborg, T., Finsen, B., Kristensen, B. W., Bak, S. T., Meyer, M., Lee, J., Nedospasov, S. A., Brambilla, R. & Lambertsen, K. L., 7. Jul 2016, In : Scientific Reports. 6, 29291.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
164 Downloads (Pure)

Genetic ablation of soluble TNF does not affect lesion size and functional recovery after moderate spinal cord injury in mice

Ellman, D. G., Degn, M., Lund, M. C., Clausen, B. H., Novrup, H. G., Flæng, S. B., Jørgensen, L. H., Suntharalingam, L., Fex Svenningsen, Å., Brambilla, R. & Lambertsen, K. L., 2016, In : Mediators of Inflammation. 2016, 2684098.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

Madsen, P. M., Clausen, B. H., Degn, M., Thyssen, S., Kristensen, L. K., Svensson, M., Ditzel, N., Finsen, B., Deierborg, T., Brambilla, R. & Lambertsen, K. L., 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 9, p. 1553-69

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Tumor Necrosis Factor-alpha
Membranes
Neuroprotection
Interleukin-6
Chemokine CXCL10
110 Downloads (Pure)

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

Bøttger, P., Glerup, S., Gesslein, B., Illarionova, N. B., Isaksen, T. J., Heuck, A., Clausen, B. H., Füchtbauer, E-M., Gramsbergen, J. B., Gunnarson, E., Aperia, A., Lauritzen, M., Lambertsen, K. L., Nissen, P. & Lykke-Hartmann, K., 25. Feb 2016, In : Scientific Reports. 6, 21 p., 22047.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
169 Downloads (Pure)

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, S. S., Spengler, B., Janfelt, C. & Hansen, H. S., 22. Dec 2016, In : Scientific Reports. 6, p. 1-14 39571.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Myelin-specific T cells induce interleukin-1beta expression in lesion-reactive microglial-like cells in zones of axonal degeneration

Grebing, M., Nielsen, H. H., Fenger, C. D., T Jensen, K., von Linstow, C. U., Clausen, B. H., Söderman, A. M., Lambertsen, K. L., Thomassen, M., Kruse, T. A. & Finsen, B., 2016, In : Glia. 64, 3, p. 407-424

Research output: Contribution to journalJournal articleResearchpeer-review

Myelin Sheath
Interleukin-1beta
Microglia
Messenger RNA
Interleukin-1 Receptors
2015

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L. & Finsen, B., 12. Mar 2015, In : Brain, Behavior, and Immunity. 48, August, p. 86–101

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Interleukin 1 Receptor Antagonist Protein
Alzheimer Disease
Neocortex
Amyloid Plaques

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

Inacio, A. R., Liu, Y., Clausen, B. H., Svensson, M., Kucharz, K., Yang, Y., Stankovich, T., Khorooshi, R. M. H., Lambertsen, K. L., Issazadeh-Navikas, S. & Deierborg, T., 2015, In : Journal of Neuroinflammation. 12, 18 p., 211.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Preserved Cerebral Microcirculation After Cardiac Arrest in a Rat Model

Secher, N., Østergaard, L., Iversen, N. K., Lambertsen, K. L., Clausen, B. H., Tønnesen, E. & Granfeldt, A., 2015, In : Microcirculation. 22, 6, p. 464-474

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development

Venø, M. T., Hansen, T. B., Venø, S. T., Clausen, B. H., Grebing, M., Finsen, B., Holm, I. E. & Kjems, J., 2015, In : Genome Biology (Online Edition). 16, November , 17 p., 245.

Research output: Contribution to journalJournal articleResearchpeer-review

RNA
brain
swine
Introns
gene
2014

Myelin specific T cells induce inflammasome activation in microglia in zones of axonal degeneration

Grebing, M. M., Nielsen, H. H., Fenger, C., Clausen, B. H., von Linstow, C. U., Jensen, K. T., Soderman, M., Lambertsen, K. L., Thomassen, M., Kruse, T. A. & Finsen, B., 2014, In : Journal of Neuroimmunology. 275, 1-2, p. 151-151

Research output: Contribution to journalJournal articleResearchpeer-review

No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, J., Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., Jul 2014, In : Journal of Neuroinflammation. 11, 13 p., 123.

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Messenger RNA
Middle Cerebral Artery
Infarction

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

Clausen, B. H., Degn, M., Martin, N. A., Couch, Y., Karimi, L., Ormhøj, M., Mortensen, M-L. B., Gredal, H., Gardiner, C., Sargent, I. I. L., Szymkowski, D. E., Petit, G., Deierborg, T., Finsen, B., Anthony, D. & Lambertsen, K. L., 12. Dec 2014, In : Journal of Neuroinflammation. 11, 1, p. 203

Research output: Contribution to journalJournal articleResearchpeer-review

2013

In situ hybridization of cytokine mRNA using alkaline phosphatase-labelled oligodeoxynucleotide probes

Clausen, B. H., Fenger, C. & Finsen, B., 2013, In : Methods in Molecular Biology. 1041, p. 83-91

Research output: Contribution to journalJournal articleResearchpeer-review

Alkaline Phosphatase
Messenger RNA
2012

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Bach, A., Clausen, B. H., Moller, M., Vestergaard, B., Chi, C. N., Round, A., Sorensen, P. L., Nissen, K. B., Kastrup, J. S., Gajhede, M., Jemth, P., Kristensen, A. S., Lundstrom, P., Lambertsen, K. L. & Stromgaard, K., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia

Lambertsen, K. L., Deierborg, T., Gregersen, R., Clausen, B. H., Wirenfeldt, M., Nielsen, H. H., Dalmau, I., Diemer, N. H., Dagnaes-Hansen, F., Johansen, F. F., Keating, A. & Finsen, B., 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 6, p. 481-494

Research output: Contribution to journalJournal articleResearchpeer-review

2010

CSF transthyretin neuroprotection in a mouse model of brain ischemia

Santos, S. D., Lambertsen, K. L., Clausen, B. H., Akinc, A., Alvarez, R., Finsen, B. & Saraiva, M. J., 1. Dec 2010, In : Journal of Neurochemistry. 115, 6, p. 1434-44 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Prealbumin
Brain
Middle Cerebral Artery Infarction
Neuroprotection
Infarction
2009

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor: Microglial Neuroprotection in Experimental Stroke

Lambertsen, K. L., Clausen, B. H., Babcock, A., Gregersen, R., Fenger, C., Nielsen, H. H., Haugaard, L. S., Wirenfeldt, M., Nielsen, M., Dagnaes-Hansen, F., Bluethmann, H., Færgeman, N. J., Meldgaard, M., Deierborg, T. & Finsen, B., 2009, In : Journal of Neuroscience. 29, 5, p. 1319-30 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Tumor Necrosis Factor-alpha
Neurons
Neuroprotective Agents
Neuroprotection

Nuclear translocation of endonuclease G in degenerating neurons after permanent middle cerebral artery occlusion in mice.

Nielsen, M., Lambertsen, K. L., Clausen, B. H., Meldgaard, M., Diemer, N. H., Zimmer, J. & Finsen, B., 1. Mar 2009, In : Experimental Brain Research. 194, 1, p. 17-27

Research output: Contribution to journalJournal articleResearchpeer-review

2008

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

Clausen, B. H., Lambertsen, K. L., Babcock, A. A., Holm, T. H., Dagnaes-Hansen, F. & Finsen, B., 1. Jan 2008, In : Journal of Neuroinflammation. 5, p. 46

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Interleukin-1beta
Tumor Necrosis Factor-alpha
Macrophages
Population
2007

Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice

Degn, M., Lambertsen, K. L., Petersen, G., Meldgaard, M., Artmann, A., Clausen, B. H., Hansen, S. H., Finsen, B., Hansen, H. S. & Lund, T. M., 1. Dec 2007, In : Journal of Neurochemistry. 103, 5, p. 1907-16 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Brain
Phospholipase D
Middle Cerebral Artery Infarction
Neurons
Young Adult

Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice

Lambertsen, K. L., Clausen, B. H., Fenger, C., Johansson, H. W., Owens, T., Dagnaes-Hansen, F., Meldgaard, M. & Finsen, B., 9. Feb 2007, In : Neuroscience. 144, 3, p. 934-49 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Tumor Necrosis Factor Receptors
Middle Cerebral Artery Infarction
Microglia
Tumor Necrosis Factor-alpha
Macrophages
2006
Glyceraldehyde-3-Phosphate Dehydrogenases
Middle Cerebral Artery Infarction
Messenger RNA
Enzymes
2004

A role for interferon-gamma in focal cerebral ischemia in mice

Lambertsen, K. L., Gregersen, R., Meldgaard, M., Clausen, B. H., Hejbøl, E. K., Ladeby, R., Knudsen, J., Frandsen, A., Owens, T. & Finsen, B., 1. Sep 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 9, p. 942-55 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Interferon-gamma
Macrophages
Microglia
Messenger RNA
Tumor Necrosis Factor Receptors