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Research Output

2020

DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1

Dirac-Svejstrup, A. B., Walker, J., Faull, P., Encheva, V., Akimov, V., Puglia, M., Perkins, D., Kümper, S., Hunjan, S. S., Blagoev, B., Snijders, A. P., Powell, D. J. & Svejstrup, J. Q., 6. Sep 2020, In : Molecular Cell.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Kappa- opioid receptor regulates human sperm functions via SPANX-A/D protein family

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Muñoa-Hoyos, I., Gómez-Giménez, B., Gianzo, M., Ganzabal, T., Blagoev, B., Kratchmarova, I. & Subiran, N., 16. Jun 2020, In : Reproductive Biology.

Research output: Contribution to journalJournal articleResearchpeer-review

Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells

Barrio-Hernandez, I., Jafari, A., Rigbolt, K. T. G., Hallenborg, P., Sanchez-Quiles, V., Skovrind, I., Akimov, V., Kratchmarova, I., Dengjel, J., Kassem, M. & Blagoev, B., Jan 2020, In : Genome Research. 30, 1, p. 127-137 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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20 Downloads (Pure)

SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Muñoa-Hoyos, I., Gianzo, M., Rodriguez, J. A., Ganzabal, T., Blagoev, B., Kratchmarova, I. & Subiran, N., 27. Mar 2020, In : Scientific Reports. 10, 9 p., 5625.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
19 Downloads (Pure)
2019

NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells

Marquez, J., Kratchmarova, I., Akimov, V., Unda, F., Ibarretxe, G., Clerigué, A. S., Osinalde, N. & Badiola, I., 1. Feb 2019, In : Oncology Reports. 41, 2, p. 742-752

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
124 Downloads (Pure)

Phosphoproteomic and functional analyses reveal sperm-specific protein changes downstream of kappa opioid receptor in human spermatozoa

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Candenas, L., Pinto, F. M., Muñoa-Hoyos, I., Gianzo, M., Matorras, R., Irazusta, J., Blagoev, B., Subiran, N. & Kratchmarova, I., 15. Mar 2019, In : Molecular and Cellular Proteomics. 18, Suppl 1, p. S118-S131

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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210 Downloads (Pure)
2018

Data on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation

Sanchez-Quiles, V., Osinalde, N., Akimov, V., Kratchmarova, I. & Blagoev, B., 1. Jun 2018, In : Data in Brief. 18, p. 1856-1863

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
158 Downloads (Pure)

SPANX A/D subfamily plays a key role in nuclear organisation, metabolism and flagellar-motility of human spermatozoa

Urizar Arenaza, I., Osinalde, N., Akimov, V., Munoa-Hoyos, I., Gianzo, M., Ganzabal, T., Irazusta, J., Subiran, N. & Kratchmarova, I., 1. Jul 2018, In : Human Reproduction. 33, Suppl. 1, p. 58 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites

Akimov, V., Olsen, L. C. B., Hansen, S. V. F., Barrio-Hernandez, I., Puglia, M., Jensen, S. S., Solov'yov, I. A., Kratchmarova, I. & Blagoev, B., 2018, In : Journal of Proteome Research. 17, 1, p. 296-304

Research output: Contribution to journalJournal articleResearchpeer-review

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Akimov, V., Barrio-Hernandez, I., Hansen, S. V. F., Hallenborg, P., Pedersen, A-K., Bekker-Jensen, D. B., Puglia, M., Christensen, S. D. K., Vanselow, J. T., Nielsen, M. M., Kratchmarova, I., Kelstrup, C. D., Olsen, J. V. & Blagoev, B., 2018, In : Nature Structural and Molecular Biology. 25, 7, p. 631-640

Research output: Contribution to journalJournal articleResearchpeer-review

2017

Characterization of receptor-associated protein complex assembly in interleukin (IL)-2- and IL-15-activated T-cell lines

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Aloria, K., Arizmendi, J. M., Blagoev, B. & Kratchmarova, I., 6. Jan 2017, In : Journal of Proteome Research. 16, 1, p. 106-121

Research output: Contribution to journalJournal articleResearchpeer-review

Cylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor

Sanchez-Quiles, V., Akimov, V., Osinalde, N., Francavilla, C., Puglia, M., Barrio-Hernandez, I., Kratchmarova, I., Olsen, J. V. & Blagoev, B., 2017, In : Molecular and Cellular Proteomics. 16, 8, p. 1433-1446 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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146 Downloads (Pure)
2016

Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes

Osinalde, N., Mitxelena, J., Sánchez-Quiles, V., Akimov, V., Aloria, K., Arizmendi, J. M., Zubiaga, A. M., Blagoev, B. & Kratchmarova, I., Jun 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 2076-92 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
206 Downloads (Pure)
2015

Method and antibodies for the identification of ubiquitina ted proteins and sites of ubiquitination

Blagoev, B., Vanselow, J. T., Akimov, V. & Nielsen, M. M., 29. Oct 2015, Patent No. WO2013020557 (A1), 29. Oct 2015, Priority date 31. Jul 2012, Priority No. US201214237626

Research output: Patent

SILAC-based quantification of changes in protein tyrosine phosphorylation induced by Interleukin-2 (IL-2) and IL-15 in T-lymphocytes

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Blagoev, B. & Kratchmarova, I., Dec 2015, In : Data in Brief. 5, p. 53-58

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
152 Downloads (Pure)

Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics

Osinalde, N., Sánchez-Quiles, V., Akimov, V., Guerra, B., Blagoev, B. & Kratchmarova, I., 2015, In : Proteomics. 15, 2-3, p. 520-31

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Phosphorylation site dynamics of early T-cell receptor signaling

Chylek, L. A., Akimov, V., Dengjel, J., Rigbolt, K. T. G., Hu, B., Hlavacek, W. S. & Blagoev, B., 2014, In : PLOS ONE. 9, 8, p. e104240

Research output: Contribution to journalJournal articleResearchpeer-review

StUbEx: Stable Tagged Ubiquitin Exchange System for the Global Investigation of Cellular Ubiquitination

Akimov, V., Henningsen, J., Hallenborg, P., Rigbolt, K. T. G., Jensen, S. S., Nielsen, M. M., Kratchmarova, I. & Blagoev, B., 2014, In : Journal of Proteome Research. 13, 9, p. 4192-4204

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Bang-bang control of T-cell receptor signaling

Chylek, L. A., Akimov, V., Dengjel, J., Rigbolt, K. T. G., Hu, B., Hlavacek, W. S. & Blagoev, B., 8. Aug 2013.

Research output: Contribution to conference without publisher/journalPosterResearch

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks

Watanabe, S., Watanabe, K., Akimov, V., Bartkova, J., Blagoev, B., Lukas, J. & Bartek, J., 2013, In : Nature Structural and Molecular Biology. 20, 12, p. 1425-33

Research output: Contribution to journalJournal articleResearchpeer-review

Role of tumor suppressor CYLD deubiquitinase in EGF signaling pathway

Sánchez-Quiles, V., Akimov, V., Barrio, I. & Blagoev, B., Sep 2013.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

Altmeyer, M. F., Toledo, L., Gudjonsson, T., Grøfte, M., Rask, M-B., Lukas, C., Akimov, V., Blagoev, B., Bartek, J. & Lukas, J., 2013, In : Molecular Cell. 52, 2, p. 206-220

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens

Dengjel, J., Høyer-Hansen, M., Nielsen, M., Eisenberg, T., Harder, L. M., Schandorff, S., Farkas, T., Kirkegaard, T., Becker, A. C., Schroeder, S., Vanselow, K., Lundberg, E., Nielsen, M. M., Kristensen, A. R., Akimov, V., Bunkenborg, J., Madeo, F., Jäättelä, M. & Andersen, J. S., 2012, In : Molecular and Cellular Proteomics. 11, 3, p. M111.014035

Research output: Contribution to journalJournal articleResearchpeer-review

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation

Hallenborg, P., Feddersen, S., Francoz, S., Murano, I., Sundekilde, U., Petersen, R. K., Akimov, V., Olson, M. V., Lozano, G., Cinti, S., Gjertsen, B. T., Madsen, L., Marine, J-C., Blagoev, B. & Kristiansen, K., 2012, In : Cell Death and Differentiation. 19, 8, p. 1381-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Quantitative comparison of differential expression level-dependent EGFR/HER2 signaling dynamics in breast cancer cell lines.

Vanselow, J. T., Akimov, V., Rigbolt, K. T. G. & Blagoev, B., Dec 2012.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

StUbEx – Stable tagged ubiquitin exchange system for global investigation of cellular ubiquitination.

Akimov, V., Henningsen, J., Hallenborg, P., Rigbolt, K. T. G., Nielsen, M. M., Kratchmarova, I. & Blagoev, B., Dec 2012.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2011

Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics

Akimov, V., Rigbolt, K. T. G., Nielsen, M. M. & Blagoev, B., 1. Dec 2011, In : Molecular BioSystems. 7, 12, p. 3223-33 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Differential comparison of EGFR/HER2-dependent signaling dynamics in breast cancer cell lines by quantitative mass spectrometry

Vanselow, J. T., Akimov, V., Rigbolt, K. T. G. & Blagoev, B., Jun 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Investigation of cell signaling regulation by ubiquitination

Akimov, V., 2011, Syddansk Universitet. Det Naturvidenskabelige Fakultet.

Research output: Monograph/anthology/thesis/reportPh.D. thesisResearch

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation

Rigbolt, K. T. G., Prokhorova, T. A., Akimov, V., Henningsen, J., Johansen, P. T., Kratchmarova, I., Kassem, M., Mann, M., Olsen, J. V. & Blagoev, B., 2011, In : Science Signaling. 4, 164, p. rs3

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Intracellular signaling discriminates between high- and low-mitogenic insulin analogues in human mammary adenocarcinoma cells

Knudsen, L., Akimov, V., Schaffer, L., Larsen, J., Oleksiewicz, M., De Meyts, P. & Blagoev, B., 2010.

Research output: Contribution to conference without publisher/journalPosterResearch

2009

Identification of EGF-stimulation specific PCM1 Interaction Partners by Quantitative Proteomics

Rigbolt, K. T. G., Akimov, V. & Blagoev, B., 2009.

Research output: Contribution to conference without publisher/journalPosterResearch

2008

Characterization of ubiquitination dependent dynamics in growth factor receptorsignaling by quantitative proteomics

Akimov, V., Rigbolt, K. T. G., Nielsen, M. M. & Blagoev, B., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

Ubiquitination dependent dynamics in growth factor receptorsignaling by quantitative proteomics

Akimov, V., Rigbolt, K. T. G., Nielsen, M. M. & Blagoev, B., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch