Alicia Babcock

  • Campusvej 55

    5230 Odense M

    Denmark

20012019
If you made any changes in Pure these will be visible here soon.

Research Output 2001 2019

Filter
Journal article
2019
53 Downloads (Pure)

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

Myhre, C. L., Thygesen, C., Villadsen, B., Vollerup, J., Ilkjær, L., Krohn, K. T., Grebing, M., Zhao, S., Khan, A. M., Dissing-Olesen, L., Jensen, M. S., Babcock, A. A. & Finsen, B., 30. Jul 2019, In : Frontiers in cellular neuroscience. 13, 17 p., 308.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Messenger RNA
Tumor Necrosis Factor-alpha
Cell Proliferation
Neurons
2018
137 Downloads (Pure)

Diverse protein profiles in CNS myeloid cells and CNS tissue from lipopolysaccharide- and vehicle-injected APPSWE/PS1ΔE9 transgenic mice implicate cathepsin Z in alzheimer’s disease

Thygesen, C., Ilkjær, L., Kempf, S. J., Hemdrup, A. L., von Linstow, C. U., Babcock, A. A., Darvesh, S., Larsen, M. R. & Finsen, B., Nov 2018, In : Frontiers in cellular neuroscience. 12, 21 p., 397.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cathepsin Z
Myeloid Cells
Alzheimer Disease
Microglia
Proteins
87 Downloads (Pure)

Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine

Severino, M., Sivasaravanaparan, M., Olesen, L. Ø., von Linstow, C. U., Metaxas, A., Bouzinova, E., Khan, A. M., Lambertsen, K. L., Babcock, A., Gramsbergen, J. B., Wiborg, O. & Finsen, B., 1. Jan 2018, In : Alzheimer's & Dementia: Translational Research & Clinical Interventions. 4, p. 215-223

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Paroxetine
Serotonin Uptake Inhibitors
Pathology
Presenilin-1
Alzheimer Disease
2017

Effect of aging and Alzheimer's disease-like pathology on brain monoamines in mice

Von Linstow, C. U., Severino, M., Metaxas, A., Waider, J., Babcock, A., Lesch, K-P., Gramsbergen, J. B. & Finsen, B., 2017, In : Neurochemistry International. 108, p. 238-245

Research output: Contribution to journalJournal articleResearchpeer-review

Alzheimer Disease
Neocortex
Pathology
Neurodegenerative Diseases
Cognition

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

Olesen, L. Ø., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O. & Finsen, B., 2017, In : Neurobiology of Disease. 104, p. 50-60

Research output: Contribution to journalJournal articleResearchpeer-review

Paroxetine
Neurons
Short-Term Memory
Serotonin Uptake Inhibitors
Alzheimer Disease
286 Downloads (Pure)

TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics

Jensen, P., Myhre, C. L., Lassen, P., Metaxas, A., Khan, A. M., Lambertsen, K. L., Babcock, A., Finsen, B., Larsen, M. R. & Kempf, S., 2017, In : OncoTarget. 8, 36, p. 60223-60242

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2016

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Deierborg, T. & Finsen, B., 2016, In : Acta Neuropathologica. 131, 5, p. 775-91

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Interleukin-1 Receptors
Microglia
Neuroprotective Agents
2015

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L. & Finsen, B., 12. Mar 2015, In : Brain, Behavior, and Immunity. 48, August, p. 86–101

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Interleukin 1 Receptor Antagonist Protein
Alzheimer Disease
Neocortex
Amyloid Plaques

Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype.

Khan, A. M., Babcock, A., Saeed, H., Myhre, C. L., Kassem, M. & Finsen, B., 2015, In : Neurobiology of Aging. 36, 6, p. 2164-75 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Telomere
Microglia
Cell Aging
Telomerase
Telomere Shortening
2014

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

Baron, R., Babcock, A. A., Nemirovsky, A., Finsen, B. & Monsonego, A., 2014, In : Aging Cell. 13, 4, p. 584-595

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Alzheimer Disease
Pathology
Amyloid Plaques

Inflammatory responses and plaque deposition in early stage Alzheimer's pathology in mice

Ilkjaer, L., Babcock, A., Myhre, C. L. & Finsen, B., 2014, In : Journal of Neuroimmunology. 275, 1-2, p. 154-155 2 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Quantification of microglial proliferation and apoptosis by flow cytometry

Babcock, A. A., Wirenfeldt, M. & Finsen, B., 2013, In : Methods in Molecular Biology. 1041, p. 129-45 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Flow Cytometry
Central Nervous System
Apoptosis
Microglia
Yolk Sac
2011

Microglia - insights into immune system structure, function, and reactivity in the central nervous system

Wirenfeldt, M., Babcock, A. A. & Vinters, H. V., 2011, In : Histology and Histopathology. 26, 4, p. 519-30 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Immune System
Central Nervous System
Population
Oligodendroglia
2009

Enhanced microglial clearance of myelin debris in T cell-infiltrated central nervous system

Nielsen, H. H., Ladeby, R., Fenger, C., Toft-Hansen, H., Babcock, A. A., Owens, T. & Finsen, B., 1. Aug 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 8, p. 845-56 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Myelin Sheath
Central Nervous System
Ovalbumin
Perforant Pathway
Myelin Basic Protein

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor: Microglial Neuroprotection in Experimental Stroke

Lambertsen, K. L., Clausen, B. H., Babcock, A., Gregersen, R., Fenger, C., Nielsen, H. H., Haugaard, L. S., Wirenfeldt, M., Nielsen, M., Dagnaes-Hansen, F., Bluethmann, H., Færgeman, N. J., Meldgaard, M., Deierborg, T. & Finsen, B., 2009, In : Journal of Neuroscience. 29, 5, p. 1319-30 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Tumor Necrosis Factor-alpha
Neurons
Neuroprotective Agents
Neuroprotection
2008

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

Clausen, B. H., Lambertsen, K. L., Babcock, A. A., Holm, T. H., Dagnaes-Hansen, F. & Finsen, B., 1. Jan 2008, In : Journal of Neuroinflammation. 5, p. 46

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Interleukin-1beta
Tumor Necrosis Factor-alpha
Macrophages
Population

NF-kappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury

Khorooshi, R., Babcock, A. A. & Owens, T., 15. Nov 2008, In : Journal of Immunology. 181, 10, p. 7284-91 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Wounds and Injuries
Neuroglia
Up-Regulation
Chemokine CCL2
Glial Fibrillary Acidic Protein

Signaling through MyD88 regulates leukocyte recruitment after brain injury

Babcock, A. A., Toft-Hansen, H. & Owens, T., 1. Nov 2008, In : Journal of Immunology. 181, 9, p. 6481-90 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Entorhinal Cortex
Wounds and Injuries
Macrophages
Interleukin-18
Interleukin-1 Receptors
2007

Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system

Toft-Hansen, H., Babcock, A. A., Millward, J. M. & Owens, T., 1. Jan 2007, In : Journal of Neuroinflammation. 4, p. 24

Research output: Contribution to journalJournal articleResearchpeer-review

Membrane-Associated Matrix Metalloproteinases
Matrix Metalloproteinases
Down-Regulation
Central Nervous System
Microglia

Microglial recruitment, activation, and proliferation in response to primary demyelination

Remington, L. T., Babcock, A. A., Zehntner, S. P. & Owens, T., 1. May 2007, In : American Journal of Pathology. 170, 5, p. 1713-24 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Population control of resident and immigrant microglia by mitosis and apoptosis

Wirenfeldt, M., Dissing-Olesen, L., Babcock, A., Nielsen, M., Meldgaard, M., Zimmer, J., Azcoitia, I., Leslie, G., Dagnaes-Hansen, F. & Finsen, B., 1. Aug 2007, In : American Journal of Pathology. 171, 2, p. 617-31 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Population Control
Microglia
Apoptosis
Perforant Pathway
DNA Nucleotidylexotransferase
2006

Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation

Babcock, A. A., Wirenfeldt, M., Holm, T., Nielsen, H. H., Dissing-Olesen, L., Toft-Hansen, H., Millward, J. M., Landmann, R., Rivest, S., Finsen, B. & Owens, T., 6. Dec 2006, In : Journal of Neuroscience. 26, 49, p. 12826-37 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2005

Microglial Heterogeneity in Injured Central Nervous System.

Nielsen, M. W., Babcock, A., Ladeby, R., Lambertsen, K. L., Dagnæs-Hansen, F., Leslie, G., Owens, T. & Finsen, B., 2005, In : Journal of Neuroscience Research. 82, p. 507-517 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Proliferating resident microglia express the stem cell antigen CD34 in response to acute neural injury

Ladeby, R., Wirenfeldt, M., Dalmau, I., Gregersen, R., García-Ovejero, D., Babcock, A., Owens, T. & Finsen, B., 15. Apr 2005, In : Glia. 50, 2, p. 121-131 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CD34 Antigens
Microglia
Wounds and Injuries
Perforant Pathway
Axotomy
2003

Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.

Babcock, A. A., Kuziel, W. A., Rivest, S. & Owens, T., 27. Aug 2003, In : Journal of Neuroscience. 23, 21, p. 7922-30 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Neuroglia
Chemokine CCL5
Chemokine CCL2
Wounds and Injuries
Axotomy