Morten Gjerstorff

cand.scient., Ph.D.

  • J.B. Winsløws Vej 25, 3.

    5000 Odense C

    Denmark

20042020
If you made any changes in Pure these will be visible here soon.

Personal profile

Research areas

Research interests

Cancer-germline (CG) antigens are among the most promising tumor targets. They are widely expressed in different cancer types and are essentially tumor-specific, since their expression in normal tissues is largely restricted to immune-privileged sites. Natural cellular and humoral immune responses against CG antigens can frequently be observed in cancer patients, indicating that they are immunogenic. These characteristics make them widely applicable as targets for cancer immunotherapy with little risk of harmful side effects and CG antigen vaccines are being evaluated in a large number of clinical trials worldwide.
Despite the great optimism about the future of CG antigen targeting therapies, two important questions remain to be answered before the full therapeutic potential of these proteins can be realized: 1) Are CG antigens directly involved in tumorigenesis? 2) Which of the more than 100 CG antigens are the best therapeutic targets? The overall aim of our research is to clarify these matters by functional characterization of CG antigens, using both functional screens to identify CG antigens involved in key pathways of tumor development and in-dept investigation of the cellular roles of specific CG antigens. We expect that our results will increase the overall understanding of tumorgenesis and can be directly translated into the clinic to improve cancer immunotherapeutic strategies.

Fingerprint Dive into the research topics where Morten Gjerstorff is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Germ Cells Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Antigens Chemical Compounds
irinotecan Medicine & Life Sciences
Gene Expression Profiling Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2020

Corrigendum to "MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis" [Free Radic. Biol. Med. 139 (2019) 1-15]

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H., Mohammadi, A., Gjerstorff, M. & Baradaran, B., Jan 2020, In : Free Radical Biology & Medicine. 146, p. 402

Research output: Contribution to journalComment/debateResearchpeer-review

miR-330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

Mansoori, B., Mohammadi, A., Naghizadeh, S., Gjerstorff, M., Shanehbandi, D., Shirjang, S., Najafi, S., Holmskov, U., Khaze, V., Duijf, P. H. G. & Baradaran, B., Feb 2020, In : Journal of Cellular Physiology. 235, 2, p. 920-931

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Colorectal Neoplasms
Down-Regulation
Apoptosis
Cell Movement
39 Downloads (Pure)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In : Cell Death & Disease. 10, 11, 12 p., 841.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus

Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19

Ormhøj, M., Scarfò, I., Cabral, M. L., Bailey, S. R., Lorrey, S. J., Bouffard, A. A., Castano, A. P., Larson, R. C., Riley, L. S., Schmidts, A., Choi, B. D., Andersen, R. S., Cédile, O., Nyvold, C. G., Haaber, J., Gjerstorff, M. F., Ditzel, H. J., Weinstock, D. M., Barington, T., Frigault, M. J. & 1 others, Maus, M. V., 1. Dec 2019, In : Clinical Cancer Research. 25, 23, p. 7046-7057

Research output: Contribution to journalJournal articleResearchpeer-review

Antigen Receptors
B-Cell Lymphoma
T-Cell Antigen Receptor
Lymphoma
CD19 Antigens
3 Downloads (Pure)

Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (Oncogene, (2018), 37, 41, (5585-5586), 10.1038/s41388-018-0495-6)

Elias, D., Vever, H., Lænkholm, A. V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., 11. Nov 2019, In : Oncogene.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
Publications
Hepatocellular Carcinoma

Activities 2014 2017

  • 2 Conference organisation or participation
  • 1 Talks and presentations in private or public companies

Chromatin and epigenetics: from mechanism to function

Nadine Brückmann (Participant), Morten Gjerstorff (Participant)
4. Apr 20177. Apr 2017

Activity: Attending an eventConference organisation or participation

Oncogenic functions of cancer/testis antigen SSX2 highlights its therapeutic potential

Morten Gjerstorff (Lecturer)
10. Feb 2015

Activity: Talks and presentationsTalks and presentations in private or public companies

2014 Annual Paris Melanoma Conference

Morten Gjerstorff (Participant)
4. Jul 20146. Jul 2014

Activity: Attending an eventConference organisation or participation

Press / Media

HÆDER

Morten Gjerstorff

22/01/2020

1 Media contribution

Press/Media: Press / Media

Nyt om navne

Morten Gjerstorff

11/01/2020

1 Media contribution

Press/Media: Press / Media

Odense-kvartet med i "Mord uden grænser"

Morten Gjerstorff

17/06/2018

1 Media contribution

Press/Media: Press / Media