19952020

Research output per year

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Research Output

2020

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., Feb 2020, In : Aging Cell. 19, 2, 8 p., e12907.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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92 Downloads (Pure)
Open Access
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17 Downloads (Pure)

Age-specific cancer rates: a bird's-eye view on progress

Rizzi, S., Wensink, M., Ahrenfeldt, L. J., Christensen, K. & Lindahl-Jacobsen, R., 6. May 2020, In : Annals of Epidemiology.

Research output: Contribution to journalJournal articleResearchpeer-review

Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies

Arbeev, K. G., Verhulst, S., Steenstrup, T., Kark, J. D., Bagley, O., Kooperberg, C., Reiner, A. P., Hwang, S. J., Levy, D., Fitzpatrick, A. L., Christensen, K., Yashin, A. I. & Aviv, A., 5. Feb 2020, In : JAMA Network Open. 3, 2, e200023.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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29 Downloads (Pure)

Author response: Use of β2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease

Pottegård, A., Hopfner, F., Wod, M., Höglinger, G. U., Blaabjerg, M., Rösler, T. W., Kuhlenbäumer, G., Christensen, K. & Deuschl, G., 19. May 2020, In : Neurology. 94, 20, 899.

Research output: Contribution to journalComment/debateResearchpeer-review

Body height in young adult men and risk of dementia later in adult life

Jørgensen, T. S. H., Okholm, G. T., Christensen, K., Sørensen, T. I. & Osler, M., 11. Feb 2020, In : eLife. 9, 11 p., e51168.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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24 Downloads (Pure)

Characteristics of Danish Centenarians’ Religious Beliefs: A Nationwide Population-Based Study

Opsahl, T., Kørup, A. K., Andersen-Ranberg, K., Christensen, K. & Hvidt, N. C., 10. Jan 2020, In : Journal of Religion and Health.

Research output: Contribution to journalJournal articleResearchpeer-review

Clonal hematopoiesis in elderly twins: concordance, discordance and mortality

Hansen, J. W., Pedersen, D. A., Larsen, L. A., Husby, S., Clemmensen, S. B., Hjelmborg, J., Favero, F., Weischenfeldt, J., Christensen, K. & Grønbæk, K., 23. Jan 2020, In : Blood. 135, 4, p. 261-268

Research output: Contribution to journalJournal articleResearchpeer-review

Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study

Long Life Family Study, 6. Mar 2020, In : Frontiers in Public Health. 8, March, 12 p., 56.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Differential long non-coding RNA profiling of body mass index in twins

Li, W., Baumbach, J., Larsen, M. J., Mohammadnejad, A., Lund, J., Christensen, K., Christiansen, L. & Tan, Q., 2020, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalJournal articleResearchpeer-review

DNA methylation QTL analysis identifies new regulators of human longevity

Szymczak, S., Dose, J., Torres, G. G., Heinsen, F-A., Venkatesh, G., Datlinger, P., Nygaard, M., Mengel-From, J., Flachsbart, F., Klapper, W., Christensen, K., Lieb, W., Schreiber, S., Häsler, R., Bock, C., Franke, A. & Nebel, A., 8. May 2020, In : Human Molecular Genetics. 29, 7, p. 1154-1167

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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8 Downloads (Pure)
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Er ældres sundhed og trivsel virkelig stagneret igennem de sidste ti år?

Translated title of the contribution: Has the general health and well-being among the elderly Danes stagnated from 2010 to 2017?Christensen, K., Kyvsgaard, I., Christensen, A. I. & Jeune, B., 16. Mar 2020, In : Ugeskrift for Laeger. V11190624.

Research output: Contribution to journalJournal articleResearchpeer-review

Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

Li, S., Lund, J., Christensen, K., Baumbach, J., Mengel-Jørgensen, J., Kruse, T. A., Li, W., Mohammadnejad, A., Pattie, A., Marioni, R. E., Deary, I. J. & Tan, Q., 28. Apr 2020, In : Genome Medicine. 12, 39, 13 p., 39 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies

Feitosa, M. F., Lunetta, K. L., Wang, L., Wojczynski, M. K., Kammerer, C. M., Perls, T., Schupf, N., Christensen, K., Murabito, J. M. & Province, M. A., Mar 2020, In : Atherosclerosis. 297, p. 102-110 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Kilpeläinen, T. O. & Lifelines Cohort Study, 5. May 2020, In : Molecular Psychiatry.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetics of physiological dysregulation: Findings from the long life family study using joint models

Arbeev, K. G., Bagley, O., Ukraintseva, S. V., Wu, D., Duan, H., Kulminski, A. M., Stallard, E., Christensen, K., Lee, J. H., Thyagarajan, B., Zmuda, J. M. & Yashin, A. I., 15. Apr 2020, In : Aging. 12, 7, p. 5920-5947

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Has the general health and well-being among the elderly Danes stagnated from 2010 to 2017?

Christensen, K., Kyvsgaard, I., Christensen, A. I. & Jeune, B., 16. Mar 2020, In : Ugeskrift for Laeger. 182, 12

Research output: Contribution to journalJournal articleResearchpeer-review

Is Religiousness Associated with Better Lifestyle and Health Among Danes? Findings from SHARE

Herold, S. C., Hvidt, N. C., Möller, S., Christensen, K. & Ahrenfeldt, L. J., 2. Jun 2020, In : Journal of Religion and Health.

Research output: Contribution to journalJournal articleResearchpeer-review

Leukocyte Telomere Length Is Unrelated to Cognitive Performance among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

Ashrafi, A., Cosentino, S., Kang, M. S., Lee, J. H., Schupf, N., Andersen, S. L., Christensen, K., Province, M. A., Thyagarajan, B., Zmuda, J. M. & Honig, L. S., 28. Apr 2020, In : Journal of the International Neuropsychological Society.

Research output: Contribution to journalJournal articleResearchpeer-review

Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex

Finkel, D., Franz, C. E., Christensen, K., Reynolds, C. A. & Pedersen, N. L., 1. Jan 2020, In : Journals of Gerontology. Series B: Psychological Sciences & Social Sciences. 75, 1, p. 1-10

Research output: Contribution to journalJournal articleResearchpeer-review

Monozygotic twin differences in perceived age

Thinggaard, M. & Christensen, K., 2020, Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors. Matias, A. & Blickstein, I. (eds.). Academic Press, p. 306-318

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits

Ahrenfeldt, L. J., Christensen, K., Segal, N. L. & Hur, Y-M., Jan 2020, In : Neuroscience & Biobehavioral Reviews. 108, p. 322-340

Research output: Contribution to journalReviewResearchpeer-review

Parallel progress in perceived age and life expectancy

Steiner, U. K., Larsen, L. A. & Christensen, K., Feb 2020, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 75, 2, p. 333-339

Research output: Contribution to journalJournal articleResearchpeer-review

Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

Sebastiani, P., Andersen, S. L., Sweigart, B., Du, M., Cosentino, S., Thyagarajan, B., Christensen, K., Schupf, N. & Perls, T. T., 8. Aug 2020, In : GeroScience.

Research output: Contribution to journalJournal articleResearchpeer-review

Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study

Santanasto, A. J., Marron, M. M., Boudreau, R. M., Feitosa, M. F., Wojczynski, M. K., Arbeev, K. G., Thyagarajan, B., Schupf, N., Stallard, E., Sebastiani, P., Cosentino, S., Christensen, K. & Newman, A. B., 17. Apr 2020, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 75, 5, p. 899-905

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Rethinking morbidity compression

Seaman, R., Höhn, A., Lindahl-Jacobsen, R., Martikainen, P., van Raalte, A. & Christensen, K., May 2020, In : European Journal of Epidemiology. 35, 5, p. 381-388

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Sex differences in health and mortality by income and income changes

Ahrenfeldt, L. J., Pedersen, J. K., Thinggaard, M., Christensen, K. & Lindahl-Jacobsen, R., Mar 2020, In : Journal of Epidemiology and Community Health. 74, 3, p. 225-231 213096.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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59 Downloads (Pure)

Sources of Stability in Social and Economic Ideological Orientations: Cohort, Context, and Construct Effects

Ksiazkiewicz, A., Klemmensen, R., Dawes, C., Christensen, K., McGue, M., Krueger, R. F. & Nørgaard, A. S., 13. Jan 2020, In : International Journal of Public Opinion Research.

Research output: Contribution to journalJournal articleResearchpeer-review

Survival after cancer for twins aged 70+

Villumsen, M. D., Christensen, K., Ewertz, M. & Hjelmborg, J. V. B., Jan 2020, Symposium i anvendt statistik 2020. Linde, P. (ed.). p. 17-26

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

The twin representativeness assumption

Christensen, K. & McGue, M., May 2020, In : Neuroscience and biobehavioral reviews. 112, p. 374-375

Research output: Contribution to journalComment/debateResearchpeer-review

β-adrenoreceptors and the risk of Parkinson's disease

Hopfner, F., Höglinger, G. U., Kuhlenbäumer, G., Pottegård, A., Wod, M., Christensen, K., Tanner, C. M. & Deuschl, G., Mar 2020, In : The Lancet Neurology. 19, 3, p. 247-254

Research output: Contribution to journalReviewResearchpeer-review

2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study & V. A. Million Veteran Program, 1. Jun 2019, In : Nature Genetics. 51, 6, p. 957-972

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?

Medford, A., Christensen, K., Skytthe, A. & Vaupel, J. W., Apr 2019, In : Demography. 56, 2, p. 665-677

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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115 Downloads (Pure)

Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Mengel-From, J., Svane, A. M., Pertoldi, C., Kristensen, T. N., Loeschcke, V., Skytthe, A., Christensen, K., Lindahl-Jacobsen, R., Hjelmborg, J. & Christiansen, L., 13. Nov 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 12, p. 1853-1860

Research output: Contribution to journalJournal articleResearchpeer-review

2 Downloads (Pure)

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 others, Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 1. Dec 2019, In : Nature Communications. 10, 1, 14 p., 3669.

Research output: Contribution to journalJournal articleResearchpeer-review

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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 32 others, Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Orellana, A., Then Bergh, F., Wang, X., Hulsman, M., Beker, N., Tesi, N., Morris, C. M., Indakoetxea, B., Collij, L. E., Scherer, M., Morenas-Rodríguez, E., Ironside, J. W., van Berckel, B. N. M., Nohr, E. A., Sørensen, T. I. A., Christensen, K. & DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), Aug 2019, In : Acta Neuropathologica. 138, 2, p. 237-250

Research output: Contribution to journalJournal articleResearchpeer-review

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A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity

Long Life Family Study, May 2019, In : Metabolism: Clinical and Experimental. 94, p. 28-38

Research output: Contribution to journalJournal articleResearchpeer-review

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APOE Alleles and Extreme Human Longevity

Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., 1. Jan 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 1, p. 44–51

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Association of low-frequency genetic variants in regulatory regions with nonsyndromic orofacial clefts

Shaffer, J. R., LeClair, J., Carlson, J. C., Feingold, E., Buxó, C. J., Christensen, K., Deleyiannis, F. W. B., Field, L. L., Hecht, J. T., Moreno, L., Orioli, I. M., Padilla, C., Vieira, A. R., Wehby, G. L., Murray, J. C., Weinberg, S. M., Marazita, M. L. & Leslie, E. J., 1. Mar 2019, In : American Journal of Medical Genetics, Part A. 179, 3, p. 467-474

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3. Jan 2019, In : American Journal of Human Genetics. 104, 1, p. 112-138

Research output: Contribution to journalJournal articleResearchpeer-review

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A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals

Carlson, J. C., Anand, D., Butali, A., Buxo, C. J., Christensen, K., Deleyiannis, F., Hecht, J. T., Moreno, L. M., Orioli, I. M., Padilla, C., Shaffer, J. R., Vieira, A. R., Wehby, G. L., Weinberg, S. M., Murray, J. C., Beaty, T. H., Saadi, I., Lachke, S. A., Marazita, M. L., Feingold, E. & 1 others, Leslie, E. J., Sep 2019, In : Genetic Epidemiology. 43, 6, p. 704-716

Research output: Contribution to journalJournal articleResearchpeer-review

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Cancer: Are offspring of long-lived siblings both robust and resilient?

Galvin, A., Pedersen, J. K., Ukraintseva, S., Perls, T. T., Wojczynski, M. K. & Christensen, K., Nov 2019, In : Innovation in Aging. 3, Suppl. 3, p. S908

Research output: Contribution to journalConference abstract in journalResearch

Open Access
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Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

Skytthe, A., Harris, J. R., Czene, K., Mucci, L., Adami, H-O., Christensen, K., Hjelmborg, J., Holm, N. V., Nilsen, T. S., Kaprio, J. & Pukkala, E., Apr 2019, In : Twin Research and Human Genetics. 22, 2, p. 99-107

Research output: Contribution to journalJournal articleResearchpeer-review

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Declining cancer incidence at the oldest ages: Hallmark of aging or lower diagnostic activity?

Pedersen, J. K., Rosholm, J-U., Ewertz, M., Engholm, G., Lindahl-Jacobsen, R. & Christensen, K., Sep 2019, In : Journal of Geriatric Oncology. 10, 5, p. 792-798

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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