Research Output

2017

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice

von Linstow, C. U., Waider, J., Grebing, M., Metaxas, A., Lesch, K. P. & Finsen, B., 2017, In : Alzheimer's Research & Therapy. 9, 12 p., 74.

Research output: Contribution to journalJournal articleResearchpeer-review

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Simultaneous Transplantation of Fetal Ventral Mesencephalic Tissue and Encapsulated Genetically Modified Cells Releasing GDNF in a Hemi-Parkinsonian Rat Model of Parkinson’s Disease

Perez-Bouza, A., Di Santo, S., Seiler, S., Meyer, M., Andereggen, L., Huber, A., Guzman, R. & Widmer, H. R., 2017, In : Cell Transplantation. 26, 9, p. 1572-1581

Research output: Contribution to journalJournal articleResearchpeer-review

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Specific Genes Associated with Adverse Events of Methylphenidate Use in the Pediatric Population: A Systematic Literature Review

Joensen, B., Meyer, M. & Aagaard, L., 16. Jun 2017, In : Journal of Research in Pharmacy Practice. 6, 2, p. 65-72

Research output: Contribution to journalJournal articleResearchpeer-review

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Spontaneous ischaemic stroke lesions in a dog brain: Neuropathological characterisation and comparison to human ischaemic stroke

Thomsen, B. B., Gredal, H., Nielsen, M. W., Kristensen, B. W., Clausen, B. H., larsen, A. E., Finsen, B., Berendt, M. & Lambertsen, K. L., 13. Jan 2017, In : Acta Veterinaria Scandinavica (Online Edition). 59, 9 p., 7.

Research output: Contribution to journalJournal articleResearchpeer-review

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Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., larsen, A. E., Babcock, A. & Darvesh, S., 2017, In : Glia. 65, S1, p. E202-E203 T05-074C .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., 8. Jul 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis

Bek, S., Bojesen, A. B., Nielsen, J. V., Sode, J., Bank, S., Vogel, U. & Andersen, V., 2017, In : Pharmacogenomics Journal. 17, p. 403–411

Research output: Contribution to journalReviewResearchpeer-review

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The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis

Cédile, O., Østerby Jørgensen, L., Frank, I., Wlodarczyk, A. & Owens, T., 2017, In : Immunology Letters. 192, p. 72-78

Research output: Contribution to journalJournal articleResearchpeer-review

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The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris

Jensen, K. T., Davidsen, L. I., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris.

Jensen, K. T., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

The loss-of-function disease-mutation G301R in the Na +/K +-ATPase α 2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice

Ellman, D. G., Isaksen, T. J., Lund, M. C., Dursun, S., Wirenfeldt, M., Jørgensen, L. H., Lykke-Hartmann, K. & Lambertsen, K. L., 8. Sep 2017, In : B M C Neuroscience. 18, 13 p., 66.

Research output: Contribution to journalJournal articleResearchpeer-review

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TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics

Jensen, P., Myhre, C. L., Lassen, P., Metaxas, A., Khan, A. M., Lambertsen, K. L., Babcock, A., Finsen, B., Larsen, M. R. & Kempf, S., 2017, In : OncoTarget. 8, 36, p. 60223-60242

Research output: Contribution to journalJournal articleResearchpeer-review

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Topical administration of TNF-inhibitor XPro1595 decreases infarct volume after experimental stroke

Yli-Karjanmaa, M. L. K., Clausen, B. H., Novrup, H. G., Szymkowski, D. E., Meyer, M., Brambilla, R. & Lambertsen, K. L., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., Citerio, G., Coburn, M., Cooper, D. J., Crowder, A. T., Czeiter, E., Czosnyka, M., Diaz-Arrastia, R., Dreier, J. P., Duhaime, A-C., Ercole, A. & 31 others, van Essen, T. A., Feigin, V. L., Gao, G., Giacino, J., Gonzalez-Lara, L. E., Gruen, R. L., Gupta, D., Hartings, J. A., Hill, S., Jiang, J-Y., Ketharanathan, N., Kompanje, E. J. O., Lanyon, L., Laureys, S., Lecky, F., Levin, H., Lingsma, H. F., Maegele, M., Majdan, M., Manley, G., Marsteller, J., Mascia, L., McFadyen, C., Mondello, S., Newcombe, V., Palotie, A., Parizel, P. M., Peul, W., Piercy, J., InTBIR Participants and Investigators & Blaabjerg, M., Dec 2017, In : Lancet Neurology. 16, 12, p. 987-1048

Research output: Contribution to journalReviewResearchpeer-review

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Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study

Cnossen, M. C., Huijben, J. A., van der Jagt, M., Volovici, V., van Essen, T., Polinder, S., Nelson, D., Ercole, A., Stocchetti, N., Citerio, G., Peul, W. C., Maas, A. I. R., Menon, D., Steyerberg, E. W., Lingsma, H. F., CENTER-TBI investigators & Blaabjerg, M., 6. Sep 2017, In : Critical Care (Online Edition). 21, 12 p., 233.

Research output: Contribution to journalJournal articleResearchpeer-review

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2016

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thöne-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlöf, B., Hallberg, A., Unger, T. & Steckelings, U. M., 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966

Research output: Contribution to journalJournal articleResearchpeer-review

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

Kempf, S. J., Metaxas, A., Ibáñez-Vea, M., Darvesh, S., Finsen, B. & Larsen, M. R., 7. Jun 2016, In : Oncotarget. 7, 23, p. 33627-33648

Research output: Contribution to journalJournal articleResearchpeer-review

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Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer

Soelberg, K., Larsen, S. R., Mørch, M., Thomassen, M., Brusgaard, K., Paul, F., Smith, T. J., Godballe, C., Grauslund, J., Lillevang, S. T. & Asgari, N., Aug 2016, In : Neurology: Neuroimmunology & Neuroinflammation. 3, 4, 4 p., e252.

Research output: Contribution to journalJournal articleResearchpeer-review

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A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica

Gebregiworgis, T., Nielsen, H. H., Massilamany, C., Gangaplara, A., Reddy, J., Illes, Z. & Powers, R., 5. Feb 2016, In : Journal of Proteome Research. 15, 2, p. 659-66 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment

Olesen, L. Ø., Bouzinova, E. V., Severino, M., Sivasaravanaparan, M., Hasselstrøm, J. B., Finsen, B. & Wiborg, O., 2016, In : PLOS ONE. 11, 11, 21 p., e0165144.

Research output: Contribution to journalJournal articleResearchpeer-review

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BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

Martin, N. A., Bonner, H., Elkjær, M. L., D'Orsi, B., Chen, G., König, H. G., Svensson, M., Deierborg, T., Pfeiffer, S., Prehn, J. H. & Lambertsen, K. L., 3. Feb 2016, In : Frontiers in Cellular Neuroscience. 10, FEB, p. 14 14.

Research output: Contribution to journalJournal articleResearchpeer-review

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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Nabuurs, R. J. A., Kapoerchan, V. V., Metaxas, A., Hafith, S., de Backer, M., Welling, M. M., Jiskoot, W., van den Nieuwendijk, A. M. C. H., Windhorst, A. D., Overkleeft, H. S., van Buchem, M. A., Overhand, M. & van der Weerd, L., 1. Dec 2016, In : Bioorganic & Medicinal Chemistry. 24, 23, p. 6139-6148 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cancellous and Cortical Bone Microarchitectures of Femoral Neck in Rheumatoid Arthritis and Osteoarthritis Compared with Donor Controls

Wang, B., Overgaard, S., Chemnitz, J. & Ding, M., 2016, In : Calcified Tissue International. 98, 5, p. 456–464

Research output: Contribution to journalJournal articleResearchpeer-review

Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death

Almeida, A. S., Soares, N. L., Vieira, M., Gramsbergen, J. B. & Vieira, H. L. A., 2016, In : P L o S One. 11, 5, 24 p., e0154781.

Research output: Contribution to journalJournal articleResearchpeer-review

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Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Deierborg, T. & Finsen, B., 2016, In : Acta Neuropathologica. 131, 5, p. 775-91

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Cerebrospinal fluid levels of catecholamine and kynurenine metabolites in Parkinson’s disease and levodopa-induced dyskinesia

Dammann Andersen, A., Havelund, J. F., Færgeman, N. J., Binzer, M., Stenager, E. & Gramsbergen, J. B., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Cerebrospinal fluid levels of catecholamine metabolites in Parkinson’s disease and L-DOPA-induced dyskinesia

Dammann Andersen, A., Binzer, M., Stenager, E., Blaabjerg, M., Havelund, J. F., Færgeman, N. J. & Gramsbergen, J. B., 3. Jul 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

Chronic, systemic LPS treatment reduces cortical Aβ levels in APP/PS1 Tg mice of two backgrounds

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Clausen, B. H., Degn, M., Sivasaravanaparan, M., Fogtmann, T., Andersen, M. G., Trojanowsky, M. D., Gao, H., Hvidsten, S., Baun, C., Deierborg, T., Finsen, B., Kristensen, B. W., Bak, S. T., Meyer, M., Lee, J., Nedospasov, S. A., Brambilla, R. & Lambertsen, K. L., 7. Jul 2016, In : Scientific Reports. 6, 29291.

Research output: Contribution to journalJournal articleResearchpeer-review

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Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept

Halle, B., Marcusson, E. G., Aaberg-Jessen, C., Jensen, S. S., Meyer, M., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2016, In : Journal of Neuro-Oncology. 126, 1, p. 47-55

Research output: Contribution to journalJournal articleResearchpeer-review

Creation of a library of induced pluritent stem cell models from Parkinsonian patients

Holmqvist, S., Lehtonen, S., Chumarina, M., Puttonen, K., Azevedo, C., Lebedeva, O., Ruponen, M., Oksanen, M., Djelloul, M., Collin, A., Goldwurm, S., Meyer, M., Lagarkova, M., Kiselev, S., Koistinaho, J. & Roybon, L., 2. Jun 2016, In : n p j Parkinson's Disease. 2, 10 p., 16009.

Research output: Contribution to journalJournal articleResearchpeer-review

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Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

Momcilovic, O., Sivapatham, R., Oron, T. R., Meyer, M., Mooney, S., Rao, M. S. & Zeng, X., 2016, In : P L o S One. 11, 5, p. e0154890

Research output: Contribution to journalJournal articleResearchpeer-review

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Dérivés d'acide fumarique á usage médical

Translated title of the contribution: Fumaric acid derivatives for medical useIllés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, IPC No. WO2016074684 A1, Patent No. PCT/DK2015/050344, 19. May 2016, Priority date 11. Nov 2014, Priority No. 62/078,05

Research output: Patent

Effect of ageing and ALzheimner-like pathology on the brain monoaminergic system.

von Linstow, C. U., Severino, M., Metaxas, A., Waider, J., Lesch, K-P., Gramsbergen, J. B. & Finsen, B., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Elucidation of the brain inflammatory network in an APP/PS1 mouse model of Alzheimer disease

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Fernandes, H. J. R., Hartfield, E. M., Christian Kjeldsen, H., Emmanoulidou, E., Zheng, Y., Booth, H., Bogetofte Thomasen, H., Lang, K. H. C., Ryan, B. J., Sardi, S. P., Badger, J., Vowles, J., Evetts, S., Tofaris, G. K., Vekrellis, K., Talbot, K., Hu, M. T., James, W. P., Cowley, S. A. & Wade-Martins, R., 2016, In : Stem Cell Reports. 6, 3, p. 342-356 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model

Jensen, S. S., Meyer, M., Petterson, S. A., Halle, B., Rosager, A. M., Aaberg-Jessen, C., Thomassen, M., Burton, M., Kruse, T. A. & Kristensen, B. W., 2016, In : P L o S One. 11, 7, p. e0159746

Research output: Contribution to journalJournal articleResearchpeer-review

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Examination of Alzheimer’s-related positive, negative and reactive pathology in the brainstem of APPswe/PS1ΔE9 mice

Finsen, B., Jul 2016. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

Four cases of gabab receptor encephalitis

Szots, M., Blaabjerg, M., Kondziella, D., Herceg, M., Dioszeghy, P., Bajzik, G., Berki, T., Kalman, E., Nagy, F. & Illes, Z., 2016, In : Ideggyogyaszati Szemle. 69, 7-8, p. 281-287

Research output: Contribution to journalJournal articleResearchpeer-review

Fumarate improves functional outcome of experimental ischemic stroke

Clausen, BH., Lundberg, L., Yli-Karjanmaa, M., Martin, N. A., Svensson, M., Alfsen, Lyngsø, K., Serrano, AB., Nielsen, H. H., Hansen, PB., Finsen, B., Deierborg, T., Illés, Z. & Lambertsen, K. L., 26. Sep 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

Fumaric acid for derivatives for medical use

Illés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, Patent No. WO2016074684 (A1), 19. May 2016, Priority date 11. Nov 2014, Priority No. US201462078051P

Research output: Patent

Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia

Dionne, N., Dib, S., Finsen, B., Denarier, E., Kuhlmann, T., Drouin, R., Kokoeva, M., Hudson, T. J., Siminovitch, K., Friedman, H. C. & Peterson, A. C., 2016, In : Glia. 64, 1, p. 175–194

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic ablation of soluble TNF does not affect lesion size and functional recovery after moderate spinal cord injury in mice

Ellman, D. G., Degn, M., Lund, M. C., Clausen, B. H., Novrup, H. G., Flæng, S. B., Jørgensen, L. H., Suntharalingam, L., Fex Svenningsen, Å., Brambilla, R. & Lambertsen, K. L., 2016, In : Mediators of Inflammation. 2016, 2684098.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

Madsen, P. M., Clausen, B. H., Degn, M., Thyssen, S., Kristensen, L. K., Svensson, M., Ditzel, N., Finsen, B., Deierborg, T., Brambilla, R. & Lambertsen, K. L., 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 9, p. 1553-69

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

Bøttger, P., Glerup, S., Gesslein, B., Illarionova, N. B., Isaksen, T. J., Heuck, A., Clausen, B. H., Füchtbauer, E-M., Gramsbergen, J. B., Gunnarson, E., Aperia, A., Lauritzen, M., Lambertsen, K. L., Nissen, P. & Lykke-Hartmann, K., 25. Feb 2016, In : Scientific Reports. 6, 21 p., 22047.

Research output: Contribution to journalJournal articleResearchpeer-review

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Hudbiopsi og kvantitativ sensorisk testning kan bidrage til diagnostik af småfiberpolyneuropati

Translated title of the contribution: Skin biopsy and quantitative sensory testing can contribute to small fibre neuropathy diagnosticsKrøigård, T., Karlsson, P., Finnerup, N. B., Sindrup, S. H. & Jensen, T. S., 20. Jun 2016, In : Ugeskrift for Laeger. 178, 19, p. 2-6 V02160134.

Research output: Contribution to journalJournal articleResearchpeer-review

Inducerede pluripotente stamceller revolutionerer forskningen i neurodegenerative sygdomme

Translated title of the contribution: Induced pluripotent stem cells revolutionise research of neurodegenerative diseasesSchmidt, S. I., Jul Knudsen, M., Bogetofte Thomasen, H. & Meyer, M., 18. Jul 2016, In : Ugeskrift for Laeger. 178, 29, p. 2-5 V03160226.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Innate Interferons Regulate CNS Inflammation

Dieu, R., Khorooshi, R. M. H., Mariboe, A., Hyre Arpe, M-L. & Owens, T., 29. Sep 2016.

Research output: Contribution to conference without publisher/journalPosterCommunication

L-DOPA-induced changes in tyrosine and tryptophan metabolites in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.

Christensen, J. B. H., Havelund, J. F. & Gramsbergen, J. B., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, S. S., Spengler, B., Janfelt, C. & Hansen, H. S., 22. Dec 2016, In : Scientific Reports. 6, p. 1-14 39571.

Research output: Contribution to journalJournal articleResearchpeer-review

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