Research Output

2018

The CROCTINO project: an international retrospective multi-center study of retinal optical coherence tomography in 501 patients with neuromyelitis optica spectrum disorders

Specovius, S., Zimmermann, H. G., Chien, C., Oertel, F. C., Cooke, L., Martinez-Lapiscina, E. H., Lana-Peixoto, M. A., Fontenelle, M. A., Palaces, J., Roca-Fernandez, A., Diaz, A. R., Leiter, M. I., Sharma, S. M., Siritho, S., Altintas, A., Yildirim, R., Tanriverdi, U., Jacob, A., Huda, S., Marignier, R. & 31 others, Nerrant, E., Cobo-Calvo, A., de Seze, J., Senger, T., Pandit, L., Dcunha, A., Soto de Castillo, I., Bichuetti, D., Maynart Tavares, I., May, E. F., Tongco, C., Havla, J., Leocani, L., Pisa, M., Radaelli, M., Aktas, O., Ringelstein, M., Rybak, J., Albrecht, P., Kim, H. J., Hyun, J. -W., Asgari, N., Soelberg, K., Mao-Draayer, Y., Stiebel-Kalish, H., Kister, I., Rimler, Z., Reid, A., Brandt, A. U., Paul, F. & [Unknown], GJCF-ICC., 1. Oct 2018, In : Multiple Sclerosis Journal. 24, Suppl. 2, p. 642-644 3 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Ultrasonography method for measuring muscle deformation

Frich, L. H., Lambertsen, K. L., Dahl, J., Larsen, A. H. & Hjarbæk, J., 9. Aug 2018, IPC No. WO 2018/141345, Patent No. PCT/DK2018/050021, 9. Aug 2018, Priority date 2. Feb 2017, Priority No. EP20170154342

Research output: Patent

2017

A novel microglial subset plays a key role in myelinogenesis in developing brain

Wlodarczyk, A., Holtman, I., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R. M. H., Benmamar-Badel, A., de Boer Bergsma, J., Martin, N. A., Karram, K., Kramer, I., Boddeke, E. W. G. M., Waisman, A., Eggen, B. J. L. & Owens, T., 2017, In : E M B O Journal. 36, 22, p. 3292-3308

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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A population-based prospective study of optic neuritis

Soelberg, K., Jarius, S., Skejoe, H. P. B., Engberg, H., Mehlsen, J., Nilsson, A. C., Madsen, J. S., Reindl, M., Wildemann, B., Grauslund, J., Kyvik, K. O., Smith, T. J., Lillevang, S. T., Paul, F., Weinshenker, B. G. & Asgari, N., 5. Oct 2017, In : Multiple sclerosis. 23, 14, p. 1893-1901

Research output: Contribution to journalJournal articleResearchpeer-review

A subpopulation of dopaminergic neurons co-expresses serotonin in ventral mesencephalic cultures but not after intrastriatal transplantation in a rat model of Parkinsons disease

Di Santo, S., Seiler, S., Ducray, A., Meyer, M. & Widmer, H., 2017, In : Cell Transplantation. 26, 4, p. 679-691

Research output: Contribution to journalJournal articleResearchpeer-review

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Autism in a "Dish": Cerebral organoids modeling neurodevelopmental pathology

Ilieva, M., Kamand, M., Fex Svenningsen, Å. & Michel, T. M., 3. Apr 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Autoimmun encefalitis debuterende med behandlingsrefraktær status epilepticus

Translated title of the contribution: Autoimmune encephalitis presenting with drug-resistant status epilepticusNissen, M. & Blaabjerg, M., 2017, In : Ugeskrift for Laeger. 179, 22, p. 1953-1954 V03170205.

Research output: Contribution to journalJournal articleResearchpeer-review

Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke

Grønhøj, M. B., Clausen, B. H., Fenger, C., Lambertsen, K. L. & Finsen, B., Oct 2017, In : Brain, Behavior, and Immunity. 65, p. 296-311

Research output: Contribution to journalJournal articleResearchpeer-review

Biomarker Research in Parkinson's Disease Using Metabolite Profiling

Havelund, J. F., Heegaard, N. H. H., Færgeman, N. J. K. & Gramsbergen, J. B., 2017, In : Metabolites. 7, 3, 18 p., 42.

Research output: Contribution to journalReviewResearchpeer-review

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CCL2 recruits T cells into the brain in a CCR2-independent manner

Cédile, O., Wlodarczyk, A. & Owens, T., 2017, In : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 11, p. 945–956

Research output: Contribution to journalJournal articleResearchpeer-review

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Cerebrospinal fluid biomarkers for Parkinson's disease: a systematic review

Dammann Andersen, A., Binzer, M., Stenager, E. & Gramsbergen, J. B., Jan 2017, In : Acta Neurologica Scandinavica. 135, 1, p. 34-56

Research output: Contribution to journalReviewResearchpeer-review

Cerebrospinal Fluid Biomarkers For Parkinson's Disease and L-DOPA-induced Dyskinesia

Dammann Andersen, A., 2017, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 111 p.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

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Cerebrospinal fluid levels of catecholamines and its metabolites in Parkinson's disease: effect of l-DOPA treatment and changes in levodopa-induced dyskinesia

Dammann Andersen, A., Blaabjerg, M., Binzer, M., Kamal, A., Thagesen, H., Kjær, T. W., Stenager, E. & Gramsbergen, J. B. P., 2017, In : Journal of Neurochemistry. 141, 4, p. 614-625

Research output: Contribution to journalJournal articleResearchpeer-review

Changes in kynurenine pathway metabolism in Parkinson patients with L-DOPA-induced dyskinesia

Havelund, J. F., Dammann Andersen, A., Binzer, M., Blaabjerg, M., Heegaard, N. H. H., Stenager, E., Faergeman, N. J. & Gramsbergen, J. B., Sep 2017, In : Journal of Neurochemistry. 142, 5, p. 756–766

Research output: Contribution to journalJournal articleResearchpeer-review

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice

Yoo, J. H., Borsodi, A., Tóth, G., Benyhe, S., Gaspar, R., Matifas, A., Kieffer, B. L., Metaxas, A., Kitchen, I. & Bailey, A., 2017, In : Neuroscience Letters. 643, p. 16-21

Research output: Contribution to journalJournal articleResearchpeer-review

Characterization of Zinc Finger Protein 804A (ZNF804A)

Christensen, K. H., 2017, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

Chronic lipopolysaccharide treatment affects cerebral amyloidosis and pathways of inflammation and synaptic plasticity in an APP/PS1 mouse model of Alzheimer's disease"

Ilkjær, L., Thygesen, C., Babcock, A., Kempf, S. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Comparative analysis of spontaneous and stimulus-evoked calcium transients in proliferating and differentiating human midbrain-derived stem cells

Johansen, T., Krabbe, C., Schmidt, S. I., Martinez-Serrano, A. & Meyer, M., 22. Oct 2017, In : Stem Cells International. 2017, 14 p., 9605432.

Research output: Contribution to journalJournal articleResearchpeer-review

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Comparison of the efficacy of azathioprine and rituximab in neuromyelitis optica spectrum disorder: a randomized clinical trial

Nikoo, Z., Badihian, S., Shaygannejad, V., Asgari, N. & Ashtari, F., 22. Aug 2017, In : Journal of Neurology. 264, 9, p. 2003-2009

Research output: Contribution to journalJournal articleResearchpeer-review

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Venø, M. T., Venø, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J., 2017, In : Frontiers in Molecular Neuroscience. 10, 10 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

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CSF biomarkers for Parkinson’s disease: Loss of glucocerebrosidase activity and alterations in modified forms of alpha-synuclein

Gramsbergen, J. B., Dammann Andersen, A., Iversen, P., Blaabjerg, M., Binzer, M., Pakkenberg, B., Brudek, T., Heegaard, N. H. H. & Stenager, E., 2017, In : Journal of Neurochemistry. 142, Suppl. 1, p. 108 1 p., MTU04-09.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

CSF catecholamine and kynurenine metabolites in Parkinson's disease and L-DOPA-induced dyskinesia

Dammann Andersen, A., Havelund, J. F., Binzer, M., Blaabjerg, M., Kamal, A., Thagesen, H., Kjær, T. W., Færgeman, N. J., Heegaard, N. H. H., Stenager, E. & Gramsbergen, J. B., 20. Aug 2017, In : Journal of Neurochemistry. 142, Suppl. 1, p. 107 1 p., MTU04-04.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Differential intrathecal inflammatory markers in acute optic neuritis and later conversion to multiple sclerosis

Olesen, M. N., Soelberg, K., Nilsson, A. C., Jarius, S., Madsen, J. S., Grauslund, J., Smith, T. J., Lillevang, S. T., Brandslund, I., Paul, F., Weinshenker, B. G. & Asgari, N., 2017. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

Siersbæk, R., Madsen, J. G. S., Javierre, B. M., Nielsen, R., Bagge, E. K., Cairns, J., Wingett, S. W., Traynor, S., Spivakov, M., Fraser, P. & Mandrup, S., 2017, In : Molecular Cell. 66, 3, p. 420-435.e5

Research output: Contribution to journalJournal articleResearchpeer-review

Effect of aging and Alzheimer's disease-like pathology on brain monoamines in mice

Von Linstow, C. U., Severino, M., Metaxas, A., Waider, J., Babcock, A., Lesch, K-P., Gramsbergen, J. B. & Finsen, B., 2017, In : Neurochemistry International. 108, p. 238-245

Research output: Contribution to journalJournal articleResearchpeer-review

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

Prajeeth, C. K., Kronisch, J., Khorooshi, R. M. H., Knier, B., Toft-Hansen, H., gudi, V., Floess, S., Huehn, J., Owens, T., Korn, T. & stangel, M., 16. Oct 2017, In : Journal of Neuroinflammation. 14, 14 p., 204.

Research output: Contribution to journalJournal articleResearchpeer-review

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Expression of Pluripotency Markers in Nonpluripotent Human Neural Stem and Progenitor Cells

Vincent, P., Benedikz, E., Uhlén, P., Hovatta, O. & Sundström, E., 2017, In : Stem Cells and Development. 26, 12, p. 876-887

Research output: Contribution to journalJournal articleResearchpeer-review

Fumarate decreases edema volume and improves functional outcome after experimental stroke

Clausen, B. H., Lundberg, L., Yli-Karjanmaa, M. L. K., Martin, N. A., Svensson, M., Zeiler Alfsen, M., Flæng, S. B., Lyngsø, K. S., Boza-Serrano, A., Nielsen, H. H., Hansen, P. B. L., Finsen, B., Deierborg, T., Illés, Z. & Lambertsen, K. L., Sep 2017, In : Experimental Neurology. 295, p. 144–154

Research output: Contribution to journalJournal articleResearchpeer-review

High content analysis of phagocytic activity and cell morphology with PuntoMorph

Al-Ali, H., Gao, H., Dalby-Hansen, C., Peters, V. A., Shi, Y. & Brambilla, R., 2017, In : Journal of Neuroscience Methods. 291, p. 43-50

Research output: Contribution to journalJournal articleResearchpeer-review

"Highly increased expression of astrocytic cytokine in neocortex of Alzheimer’s patients investigated by proteomics"

Thygesen, C., Kempf, S., Metaxas, A., Darvesh, S., Larsen, M. R. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination

Berg, C. T., Khorooshi, R. M. H., Asgari, N. & Owens, T., 24. Jun 2017, In : Journal of Neuroinflammation. 14, p. 127-134 8 p., 127.

Research output: Contribution to journalJournal articleResearchpeer-review

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Interleukin-6 is increased in plasma and cerebrospinal fluid of community-dwelling domestic dogs with acute ischaemic stroke

Gredal, H., Thomsen, B. B., Boza-Serrano, A., Garosi, L., Rusbridge, C., anthony, D., Møller, A., Finsen, B., Deierborg, T., Lambertsen, K. L. & Berendt, M., 8. Feb 2017, In : NeuroReport. 28, 3, p. 134-140

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

Fex Svenningsen, Å., Loering, S., Sørensen, A. L., Uyen Buu Huynh, H., Hjæresen, S., Martin, N. A., Møller, J. B., Elkjær, M. L., Holmskov, U., Illés, Z., Andersson, M., Nielsen, S. B. & Benedikz, E., 2017, In : Cellular and Molecular Life Sciences. 74, 24, p. 4561–4572

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Neurodevelopment in a Dish: Elucidates the Miechanisms of Autism SDpectrum Disorders

Ilieva, M., Kolev, K. V., Forsberg, S. L., Fex Svenningsen, Å. & Michel, T. M., 2. Apr 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

"Neurodevelopment in a dish" Elucidates the mechanisms of autism spectrum disorders

Ilieva, M., Kamand, M., Kolev, K. V., Forsberg, S. L., Fex Svenningsen, Å. & Michel, T. M., 2017.

Research output: Contribution to conference without publisher/journalPosterResearch

Neuronal Ablation of IKK2 Decreases Lesion Size and Improves Functional Outcome after Spinal Cord Injury in Mice

Ellman, D. G., Novrup, H. G., Jørgensen, L. H., Lund, M. C., Yli-Karjanmaa, M. L. K., Madsen, P. M., Vienhues, J. H., Dursun, S., Bethea, J. R., Lykke-Hartmann, K., Brambilla, R. & Lambertsen, K. L., 2017, In : JSM Neurosurgery and Spine. 5, 3, 14 p., 1090.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

Olesen, L. Ø., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O. & Finsen, B., 2017, In : Neurobiology of Disease. 104, p. 50-60

Research output: Contribution to journalJournal articleResearchpeer-review

Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside

Blindbæk, S. L., Torp, T. L., Lundberg, K., Soelberg, K., Vergmann, A. S., Poulsen, C. D., Frydkjær-Olsen, U., Broe, R., Rasmussen, M. L., Wied, J., Lind, M., Vestergaard, A. H., Peto, T. & Grauslund, J., 13. Apr 2017, In : Journal of Diabetes Research. 2017, 10 p., 2562759.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Normalization of Neurofilament Light Chain levels in the CSF after treatment with Dimethyl fimarate.

Mathiesen, T. S., Nielsen, H. H., Ravnborg, M. & Illés, Z., 25. Oct 2017, In : Multiple Sclerosis Journal. 23, p. 582-583

Research output: Contribution to journalConference abstract in journalResearch

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Kononenko, O., Bazov, I., Watanabe, H., Gerashchenko, G., Dyachok, O., Verbeek, D. S., Alkass, K., Druid, H., Andersson, M., Mulder, J., Fex Svenningsen, Å., Rajkowska, G., Krishtal, O., Yakovleva, T. & Bakalkin, G., Feb 2017, In : B B A - General Subjects. 1861, 2, p. 246–255

Research output: Contribution to journalJournal articleResearchpeer-review

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Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis

Gao, H., Danzi, M., Choi, C. S., Taherian, M., Dalby-Hansen, C., Ellman, D. G., Madsen, P. M., Bixby, J. L., Lemmon, V. P., Lambertsen, K. L. & Brambilla, R., 3. Jan 2017, In : Cell Reports. 18, 1, p. 198-212

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

Zhang, Y., Schmid, B., Nikolaisen, N. K., Rasmussen, M. A., Aldana, B. I., Agger, M., Calloe, K., Stummann, T. C., Larsen, H. M., Nielsen, T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., FReJA Consortium & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, K. K., 2017, In : Stem Cell Reports. 8, 3, p. 648-658

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Post-transcriptional regulation of tumor necrosis factor and other microglial-produced cytokines

Jensen, K. T., Nielsen, H. H., Kjems, J. & Finsen, B., 24. May 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Recent progress in translational research on neurovascular and neurodegenerative disorders

Demuth, H-U., Dijkhuizen, R. M., Farr, T. D., Gelderblom, M., Horsburgh, K., Iadecola, C., Mcleod, D. D., Michalski, D., Murphy, T. H., Orbe, J., Otte, W. M., Petzold, G. C., Plesnila, N., Reiser, G., Reymann, K. G., Rueger, M. A., Saur, D., Savitz, S. I., Schilling, S., Spratt, N. J. & 8 others, Turner, R. J., Vemuganti, R., Vivien, D., Yepes, M., Zille, M., Boltze, J., ISN&N meeting contributors & Lambertsen, K. L., 1. Jan 2017, In : Restorative Neurology and Neuroscience. 35, 1, p. 87-103

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Role of microglial subsets in health and disease

Wlodarczyk, A., 2017, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

Secondary injury mechanisms after moderate spinal cord injury in mice

Ellman, D. G., 2017, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study

Nordin, A., Akimoto, C., Wuolikainen, A., Alstermark, H., Forsberg, K., Baumann, P., Pinto, S., de Carvalho, M., Hübers, A., Nordin, F., Ludolph, A. C., Weishaupt, J. H., Meyer, T., Grehl, T., Schweikert, K., Weber, M., Burkhardt, C., Neuwirth, C., Holmøy, T., Morita, M. & 9 others, Tysnes, O. B., Benatar, M., Wuu, J., Lange, D. J., Bisgård, C., Asgari, N., Tarvainen, I., Brännström, T. & Andersen, P. M., 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 3-4, p. 256-264

Research output: Contribution to journalJournal articleResearchpeer-review