Research Output

2020

Acute neurofilament light chain plasma levels correlate with stroke severity and clinical outcome in ischemic stroke patients

Nielsen, H. H., Soares, C. B., Høgedal, S. S., Madsen, J. S., Hansen, R. B., Christensen, A. A., Madsen, C., Clausen, B. H., Frich, L. H., Degn, M., Sibbersen, C. & Lambertsen, K. L., 28. Apr 2020, (Accepted/In press) In : Frontiers in Neurology.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis

Chalmer, T. A., Buron, M., Illes, Z., Papp, V., Theodorsdottir, A., Schäfer, J., Hansen, V., Asgari, N., Skejø, P. B., Jensen, H. B., Sørensen, P. S. & Magyari, M., Jan 2020, In : Journal of Neurology, Neurosurgery and Psychiatry. 91, 1, p. 67-74

Research output: Contribution to journalJournal articleResearchpeer-review

Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice

Rosenstand, K., Andersen, K., Terp, R., Gennemark, P., Ellman, D. G., Reznichenko, A., Lambertsen, K. L., Vanhoutte, P. M., Hansen, P. B. L. & Svenningsen, P., 21. Jan 2020, (Accepted/In press) In : Journal of Physiology and Biochemistry.

Research output: Contribution to journalJournal articleResearchpeer-review

Diagnosis and long-term outcome in dogs with acute onset intracranial signs

Gredal, H., Thomsen, B. B., Westrup, U., Boza-Serrano, A., Deierborg, T., McEvoy, F., Platt, S., Lambertsen, K. L. & Berendt, M., Feb 2020, In : Journal of Small Animal Practice. 61, 2, p. 101-109

Research output: Contribution to journalJournal articleResearchpeer-review

Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis

Chuhutin, A., Hansen, B., Wlodarczyk, A., Owens, T., Shemesh, N. & Jespersen, S. N., Mar 2020, In : NeuroImage. 208, 14 p., 116406.

Research output: Contribution to journalJournal articleResearchpeer-review

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IC100: A novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

Desu, H. L., Plastini, M., Illiano, P., Bramlett, H. M., Dietrich, W. D., De Rivero Vaccari, J. P., Brambilla, R. & Keane, R. W., 4. May 2020, In : Journal of Neuroinflammation. 17, 10 p., 143.

Research output: Contribution to journalJournal articleResearchpeer-review

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Increased Neuroprotective Microglia and Photoreceptor Survival in the Retina from a Peptide Inhibitor of Myeloid Differentiation Factor 88 (MyD88)

Garces, K., Carmy, T., Illiano, P., Brambilla, R. & Hackam, A. S., 18. Feb 2020, In : Journal of Molecular Neuroscience.

Research output: Contribution to journalJournal articleResearchpeer-review

Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis

Olesen, M. N., Wuolikainen, A., Nilsson, A. C., Wirenfeldt, M., Forsberg, K., Madsen, J. S., Lillevang, S. T., Brandslund, I., Andersen, P. M. & Asgari, N., May 2020, In : Neurology: Neuroimmunology & Neuroinflammation. 7, 3, 14 p., e697.

Research output: Contribution to journalJournal articleResearchpeer-review

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Innate signaling within the central nervous system recruits protective neutrophils

Khorooshi, R., Marczynska, J., Dieu, R. S., Wais, V., Hansen, C. R., Kavan, S., Thomassen, M., Burton, M., Kruse, T., Webster, G. A. & Owens, T., 8. Jan 2020, In : Acta Neuropathologica Communications. 8, 13 p., 2.

Research output: Contribution to journalJournal articleResearchpeer-review

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Neurofilaments: The C-Reactive Protein of Neurology

Lambertsen, K. L., Soares, C. B., Gaist, D. & Nielsen, H. H., 16. Jan 2020, In : Brain Sciences. 10, 1, 29 p., 56.

Research output: Contribution to journalReviewResearchpeer-review

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Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

Madsen, P. M., Desu, H. L., Pablo de Rivero Vaccari, J., Florimon, Y., Ellman, D. G., Keane, R. W., Clausen, B. H., Lambertsen, K. L. & Brambilla, R., Feb 2020, In : Brain, Behavior, and Immunity. 84, p. 132-146

Research output: Contribution to journalJournal articleResearchpeer-review

Protective Microglial Subset in Development, Aging, and Disease: Lessons From Transcriptomic Studies

Benmamar-Badel, A., Owens, T. & Wlodarczyk, A., 3. Apr 2020, In : Frontiers in Immunology. 11, 19 p., 430.

Research output: Contribution to journalReviewResearchpeer-review

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Supraspinatus and deltoid muscle fiber composition in rotator cuff tear conditions

Ravn, M. K., Ostergaard, T. I., Schrøder, H. D., Nyengaard, J. R., Lambertsen, K. L. & Frich, L. H., 17. Apr 2020, (Accepted/In press) In : JSES International.

Research output: Contribution to journalJournal articleResearchpeer-review

The mutual interplay of gut microbiota, diet and human disease

Illiano, P., Brambilla, R. & Parolini, C., Mar 2020, In : FEBS Journal. 287, 5, p. 833-855

Research output: Contribution to journalReviewResearchpeer-review

Open Access

The serine protease HTRA1 increases in the brain and CSF in Multiple Sclerosis

Hjæresen, S., Sejbæk, T., Axelsson, M., Phil- Jensen, G., Jensen, H. V., Kløvedal Mortensen, S., Pedersen, C. B., Halle, B., Rom Poulsen, F., Zhang, M., Battistini, J. L., Lycke, J., Illés, Z. & Fex Svenningsen, Å., 2020.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

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2019

Absence of miR-146a alters the function and proteome of microglia

Hyrlov, K. H., Martin, N. A., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Okarmus, J., Benedikz, E., Stensballe, A., Svenningsen, A. F., Owens, T. & Illes, Z., 1. Sep 2019, In : Multiple Sclerosis Journal. 25, 2 Suppl. 1, p. 651-652 P1203.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., Brooks, D. J., Larsen, M. R. & Finsen, B., 31. Oct 2019, In : Scientific Reports. 9, 1, 15 p., 15758.

Research output: Contribution to journalJournal articleResearchpeer-review

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An experimental model of Neuromyelitis Optica Spectrum Disorder (NMOSD)-Optic Neuritis: Insights into disease mechanisms

Soerensen, S. F., Soelberg, K., Wlodarczyk, A., Moerch, M. T., Arengoth, D. S., Owens, T. & Asgari, N., 1. Sep 2019, In : Multiple Sclerosis Journal. 25, 2 Suppl. 1, p. 363-364 P725.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, E. U., Tygesen, C., Montañana Rosell, R., Limburg, H. L., Marczynska, J., Asgari, N., Steckelings, M. & Owens, T., 9. Jul 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalJournal articleResearchpeer-review

Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, E. U., Thygesen, C., Montanana-Rosel, R., Limburg, H. L., Asgari, N., Steckelings, U. M. & Owens, T., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E353-E354

Research output: Contribution to journalConference abstract in journalResearch

Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, U. E., Tygesen, C., Montanana-Rosell, R., Limburg, L. H., Marczynska, J., Asgari, N., Steckelings, M. U. & Owens, T., Oct 2019, In : European Journal of Immunology. 49, Suppl. 3, p. 1435 1 p., P0430.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes

Andersson, C. R., Falsig, J., Stavenhagen, J. B., Christensen, S., Kartberg, F., Rosenqvist, N., Finsen, B. & Pedersen, J. T., 15. Mar 2019, In : Scientific Reports. 9, 1, 12 p., 4658.

Research output: Contribution to journalJournal articleResearchpeer-review

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A Prospective Observational Feasibility Study of Jugular Bulb Microdialysis in Subarachnoid Hemorrhage

Forsse, A., Nielsen, T. H., Mølstrøm, S., Hjelmborg, J. V. B., Stokbro, K., Nygaard, K. H., Yilmaz, S., Nordström, C-H. & Rom Poulsen, F., 16. Dec 2019, In : Neurocritical Care.

Research output: Contribution to journalJournal articleResearchpeer-review

Astroglial TNFR2 signaling is implicated in the regulation of learning, memory and anxiety

Illiano, P., Desu, H., Plastini, M., Mudalegundi, S., Moosa, M., Yli-Karjanmaa, M. & Brambilla, R., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E369-E370

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi, S., Doosti, R., Shahmohammadi, A., Mohammadianinejad, S. E., Sahraian, M. A., Azimi, A. R., Harirchian, M. H., Asgari, N. & Naser Moghadasi, A., Jan 2019, In : Multiple Sclerosis and Related Disorders. 27, p. 350-363

Research output: Contribution to journalReviewResearchpeer-review

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Bilateral anterior cerebral artery infarction presenting with acute paraparesis and parkinsonism

Forsberg, J., Blaabjerg, M., Diaz, A., Agerbo Gaist, T., Christensen, A. & Gaist, D., Dec 2019, In : Neurology: Clinical Practice. 9, 6, p. 494-496

Research output: Contribution to journalJournal articleResearchpeer-review

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[3 H]3 methoxy phenyl)-N'-methylguanidine ([3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Metaxas, A., van, B. BNM., Klein, PJ., Verbeek, J., Nash, EC., Kooijman, EJM., Renjaän, VA., Golla, SSV., Boellaard, R., Christiaans, JAM., Windhorst, AD. & Leysen, JE., Feb 2019, In : Pharmacology Research & Perspectives. 7, 1, 15 p., e00458.

Research output: Contribution to journalJournal articleResearchpeer-review

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Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

Olesen, M. N., Soelberg, K., Debrabant, B., Nilsson, A. C., Lillevang, S. T., Grauslund, J., Brandslund, I., Madsen, J. S., Paul, F., Smith, T. J., Jarius, S. & Asgari, N., 11. Mar 2019, In : Journal of Neuroinflammation. 16, 12 p., 59.

Research output: Contribution to journalJournal articleResearchpeer-review

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Cladribine modifies functional properties of murine microglia

Jorgensen, L., Hyrlov, K. H., Elkjaer, M. L., Pedersen, A. E., Svenningsen, A. F. & Illes, Z., 1. Sep 2019, In : Multiple Sclerosis Journal. 25, 2 Suppl. 1, p. 527 1 p., P997.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Clinically Suspected Cast Nephropathy: A Retrospective, Multi-Center, Real-World Study

Szabo, A. G., Thorsen, J., Hansen, C. T., Vase, M. Ø., Teodorescu, M., Pedersen, S. B., Flæng, S. B., Frølund, U. C., Vangsted, A. J. & Plesner, T., 13. Nov 2019, In : Blood. 134, Suppl. 1, p. 5553-5553 1 p.

Research output: Contribution to journalConference abstract in journalResearch

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Cook, L. J., Rose, J. W., Alvey, J. S., Jolley, A. M., Kuhn, R., Marron, B., Pederson, M., Enriquez, R., Yearley, J., McKechnie, S., Han, M. H., Tomczak, A. J., Levy, M., Mealy, M. A., Coleman, J., Bennett, J. L., Johnson, R., Barnes-Garcia, M., Traboulsee, A. L., Carruthers, R. L. & 42 others, Lee, L. E., Schubert, J. J., McMullen, K., Kister, I., Rimler, Z., Reid, A., Sicotte, N. L., Planchon, S. M., Cohen, J. A., Ivancic, D., Sedlak, J. L., Sand, I. K., Repovic, P., Amezcua, L., Pruitt, A., Amundson, E., Chitnis, T., Mullin, D. S., Klawiter, E. C., Russo, A. W., Riley, C. S., Onomichi, K. B., Levine, L., Nelson, K. E., Nealon, N. M., Engel, C., Kruse-Hoyer, M., Marcille, M., Tornes, L., Rumpf, A., Greer, A., Behne, M. K., Rodriguez, R. R., Behne, D. W., Blackway, D. W., Coords, B., Blaschke, T. F., Sheard, J., Smith, T. J., Behne, J. M., Yeaman, M. R. & The Guthy-Jackson Charitable Foundation International Clinical Consortium (GJCF–ICC), Sep 2019, In : Neurology: Neuroimmunology & Neuroinflammation. 6, 5, 17 p., e583.

Research output: Contribution to journalJournal articleResearchpeer-review

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Corrigendum to “Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9transgenic mice: Effect of long-term treatment with paroxetine" [Neurobiol Dis. 2017; 104: 50-60].

Olesen, LØ., Sivasaravanaparan, M., Severino, M., Babcock, A. A., Bouzinova, E. V., West, M. J., Wiborg, O. & Finsen, B., Apr 2019, In : Neurobiology of Disease. 124, p. 573

Research output: Contribution to journalComment/debateResearchpeer-review

CSF1R stimulation promotes increased neuroprotection by CD11c+microglia in EAE

Benmamar-Badel, A., Wlodarczyk, A., Cedile, O., Jensen, K. N., Kramer, I., Elsborg, N. B. & Owens, T., Dec 2019, In : Scandinavian Journal of Immunology. 90, 6, p. 4 1 p., 7.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE

Wlodarczyk, A., Benmamar-Badel, A., Cédile, O., Nolling Jensen, K., Kramer, I., Elsborg, N. B. & Owens, T., 10. Jan 2019, In : Frontiers in Cellular Neuroscience. 12, 10 p., 523.

Research output: Contribution to journalJournal articleResearchpeer-review

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Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia

Forsse, A., Nielsen, T. H., Nygaard, K. H., Nordström, C-H., Gramsbergen, J. B. & Poulsen, F. R., 2019, In : Scientific Reports. 9, 1, 3702.

Research output: Contribution to journalJournal articleResearchpeer-review

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Disability and Therapeutic Response in Paediatric Neuromyelitis Optica Spectrum Disorder: A Case Series from Iran

Baghbanian, S. M., Sahraian, M. A., Naser Moghadasi, A. & Asgari, N., 2019, In : Iranian Journal of Child Neurology. 13, 3, p. 99-104

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Effect of Home-Based High-Intensity Interval Training in Patients with Lacunar Stroke: A Randomized Controlled Trial

Krawcyk, R. S., Vinther, A., Petersen, N. C., Faber, J., Iversen, H. K., Christensen, T., Lambertsen, K. L., Rehman, S., Klausen, T. W., Rostrup, E. & Kruuse, C., 28. Jun 2019, In : Frontiers in Neurology. 10, JUN, 15 p., 664.

Research output: Contribution to journalJournal articleResearchpeer-review

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Epidemiology of neuromyelitis optica spectrum disorder in Denmark (1998-2008, 2007-2014)

Asgari, N., Lillevang, S. T., Skejoe, H. P. B. & Kyvik, K. O., Jul 2019, In : Brain and Behavior. 9, 7, 8 p., e01338.

Research output: Contribution to journalJournal articleResearchpeer-review

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Ethyl Pyruvate Treatment Increases Post-ischemic Levels of Selected Metabolites Detected by Labelled Cerebral Microdialysis

Nygaard, K. H., Havelund, J., Nielsen, T. H., Færgeman, N. J., Nordström, C-H., Rom Poulsen, F., Gramsbergen, J. B. & Forsse, A., 2019, In : Stroke. 50, Suppl. 1, p. TP318

Research output: Contribution to journalConference abstract in journalResearchpeer-review

How does MIF regulate CNS glia

Hjæresen, S., Kronborg, H., Mortensen, S. K. S., Illés, Z. & Fex Svenningsen, Å., 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients

Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A. M., Darvesh, S. & Finsen, B., 5. Dec 2019, In : Frontiers in cellular neuroscience. 13, 8 p., 538.

Research output: Contribution to journalJournal articleResearchpeer-review

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Influence of migration on the prognosis of neuromyelitis optica spectrum disorder in non-Caucasian patients

Soares dos Reis, R., Tsz-Ching, J. L., Kim, S. -H., d'Cunha, A., Jacob, A., Berthelot, E., Nakashima, I., Tye, J. S. N., Jitprapaikulsan, J., Tan, K., Yang, L., Leite, M. I., Mealy, M. A., Levy, M., Fan, M., Asgari, N., Cabre, P., Siritho, S., Pittock, S. J., Wing-Ho, S. C. & 5 others, Yeo, T., Takai, Y., Pandit, L., Kim, H. J. & Palace, J., 1. Sep 2019, In : Multiple Sclerosis Journal. 25, 2 Suppl. 1, p. 138-139 P359.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Innate signaling in central nervous system recruits myeloid suppressor cells

Marczynska, J., Khorooshi, R., Wais, V., Dieu, R. S., Hansen, C. R., Kavan, S., Thomassen, M., Burton, M., Kruse, T., Webster, G. A. & Owens, T., Dec 2019, In : Scandinavian Journal of Immunology. 90, 6, p. 17 1 p., 39.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Learning Anatomy with Augmented Reality: – learning design and app design for optimal learning

Nørgaard, C., Dyhrberg O'Neill, L., Chemnitz, J. & Majgaard, G., 31. Mar 2019, In : Læring og Medier (LOM). 12, 20, 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Long-term tolerability, safety and efficacy of rituximab in neuromyelitis optica spectrum disorder: a prospective study

Shaygannejad, V., Fayyazi, E., Badihian, S., Mirmosayyeb, O., Manouchehri, N., Ashtari, F. & Asgari, N., Mar 2019, In : Journal of Neurology. 266, 3, p. 642-650

Research output: Contribution to journalJournal articleResearchpeer-review

Mechanism underlying focal demyelination induced by antibody or T cells

Mørch, M., 12. Apr 2019, Odense: Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

Myhre, C. L., Thygesen, C., Villadsen, B., Vollerup, J., Ilkjær, L., Krohn, K. T., Grebing, M., Zhao, S., Khan, A. M., Dissing-Olesen, L., Jensen, M. S., Babcock, A. A. & Finsen, B., 30. Jul 2019, In : Frontiers in cellular neuroscience. 13, 17 p., 308.

Research output: Contribution to journalJournal articleResearchpeer-review

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Microglial-derived transmembrane TNF versus soluble TNF: The good and the bad?

Yli-Karjanmaa, M. L. K., 2019, Odense: Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

Microglia-myelinogenic and neuroprotective cells of the CNS.

Wlodarczyk, A., Benmamar-Badel, A., Jensen, K. N., Lyszczarz, G. & Owens, T., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E554-E555

Research output: Contribution to journalConference abstract in journalResearch

MIF and HTRA1 – new potential biomarkers for MS?

Hjæresen, S., Sejbæk, T., Axelsson, M., Lycke, J., Illés, Z. & Fex Svenningsen, Å., 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

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