IRS - The Capital Region of Denmark, Copenhagen Trial Unit (CTU), Rigshospitalet

Research output

Research output per year 1976 2021 2022 2023

• 141 Journal article
• 14 Comment/debate
• 2 Editorial
• 1 Book chapter
• 3 More
  • 1 Conference abstract for conference
  • 1 Conference abstract in journal
  • 1 Ph.D. thesis

Research output per year

Research output per year

Search results

• 2020

  Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

  Lilja, G., Nielsen, N., Ullén, S., Blennow Nordstrom, E., Dankiewicz, J., Friberg, H., Heimburg, K., Jakobsen, J. C., Levin, H., Callaway, C., Cariou, A., Eastwood, G. M., Helbok, R., Hovdenes, J., Kirkegaard, H., Leithner, C., Morgan, M. P. G., Nordberg, P., Oddo, M., Pelosi, P., & 7 othersRylander, C., Saxena, M., Taccone, F. S., Siranec, M., Wise, M. P., Young, P. J. & Cronberg, T., May 2020, In: Resuscitation. 150, p. 104-112

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Out-of-Hospital Cardiac Arrest 100%
  • Hypothermia 81%
  • Glasgow Outcome Scale 77%
  • Survivors 51%
  • Induced Hypothermia 48%
  33 Downloads (Pure)

• Psychotherapy versus treatment as usual and other control interventions in children and adolescents with overweight and obesity: A protocol for systematic review with meta-analysis and Trial Sequential Analysis

  Rashid, R., Condon, L., Gluud, C., Jakobsen, J. C., Lindschou, J. & Lissau, I., 5. Nov 2020, In: BMJ Open. 10, 11, 7 p., e036058.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Pediatric Obesity 100%
  • Psychotherapy 90%
  • Meta-Analysis 69%
  • Systematic Reviews 68%
  • Overweight 61%
  31 Downloads (Pure)

• Reporting of methodological studies in health research: A protocol for the development of the MethodologIcal STudy reportIng Checklist (MISTIC)

  Lawson, D. O., Puljak, L., Pieper, D., Schandelmaier, S., Collins, G. S., Brignardello-Petersen, R., Moher, D., Tugwell, P., Welch, V. A., Samaan, Z., Thombs, B. D., Nørskov, A. K., Jakobsen, J. C., Allison, D. B., Mayo-Wilson, E., Young, T., Chan, A. W., Briel, M., Guyatt, G. H., Thabane, L., & 1 othersMbuagbaw, L., 17. Dec 2020, In: BMJ Open. 10, 12, 11 p., e040478.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Checklist 100%
  • Health 50%
  • Guidelines 24%
  • Ethics 18%
  • Congresses 18%
  25 Downloads (Pure)

• Sertraline in primary care: comments on the PANDA trial

  Hengartner, M. P., Plöderl, M., Braillon, A., Jakobsen, J. C. & Gluud, C., Jan 2020, In: The lancet. Psychiatry. 7, 1, p. 17 1 p.

  Research output: Contribution to journal › Journal article › Research

• Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: A statistical analysis plan

  Jakobsen, J. C., Dankiewicz, J., Lange, T., Cronberg, T., Lilja, G., Levin, H., Bělohlávek, J., Callaway, C., Cariou, A., Erlinge, D., Hovdenes, J., Joannidis, M., Nordberg, P., Oddo, M., Pelosi, P., Kirkegaard, H., Eastwood, G., Rylander, C., Saxena, M., Storm, C., & 8 othersTaccone, F. S., Wise, M. P., Morgan, M. P. G., Young, P., Nichol, A., Friberg, H., Ullén, S. & Nielsen, N., 7. Oct 2020, In: Trials. 21, 831.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Out-of-Hospital Cardiac Arrest 100%
  • Induced Hypothermia 96%
  • Hypothermia 81%
  • Heart Arrest 58%
  • Equivalence Trials 25%
  28 Downloads (Pure)

• Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

  Korang, S. K., Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Ong, G., Klingenberg, S., Veroniki, A. A., Bu, F., Thabane, L., Thomsen, A. R., Jakobsen, J. C. & Gluud, C., 20. Nov 2020, In: Systematic Reviews. 9, 15 p., 262.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Network Meta-Analysis 100%
  • Coronavirus 93%
  • Vaccines 55%
  • Systematic Reviews 54%
  • Randomized Controlled Trials 21%
  44 Downloads (Pure)
• 2019

  Methodological advantages and disadvantages of parallel and crossover randomised clinical trials on methylphenidate for attention deficit hyperactivity disorder: A systematic review and meta-analyses

  Krogh, H. B., Storebø, O. J., Faltinsen, E., Todorovac, A., Ydedahl-Jensen, E., Magnusson, F. L., Holmskov, M., Gerner, T., Gluud, C. & Simonsen, E., 30. Mar 2019, In: BMJ Open. 9, 3, 10 p., e026478.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Methylphenidate 100%
  • Attention Deficit Disorder with Hyperactivity 81%
  • Cross-Over Studies 73%
  • Meta-Analysis 60%
  • Systematic Reviews 59%
  6 Downloads (Pure)
• 2018

  Systematic overview and critical appraisal of meta-analyses of interventions in intensive care medicine

  Koster, T. M., Wetterslev, J., Gluud, C., Keus, F. & van der Horst, I. C. C., Sep 2018, In: Acta Anaesthesiologica Scandinavica. 62, 8, p. 1041-1049 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Care 100%
  • Meta-Analysis 84%
  • Medicine 83%
  • Systematic Reviews 13%
  • Randomized Controlled Trials 12%
• 2017

  Sharing and reuse of individual participant data from clinical trials: Principles and recommendations

  Ohmann, C., Banzi, R., Canham, S., Battaglia, S., Matei, M., Ariyo, C., Becnel, L., Bierer, B., Bowers, S., Clivio, L., Dias, M., Druml, C., Faure, H., Fenner, M., Galvez, J., Ghersi, D., Gluud, C., Groves, T., Houston, P., Karam, G., & 21 othersKalra, D., Knowles, R. L., Krleža-Jerić, K., Kubiak, C., Kuchinke, W., Kush, R., Lukkarinen, A., Marques, P. S., Newbigging, A., O'Callaghan, J., Ravaud, P., Schlünder, I., Shanahan, D., Sitter, H., Spalding, D., Tudur-Smith, C., Van Reusel, P., Van Veen, E. B., Visser, G. R., Wilson, J. & Demotes-Mainard, J., 1. Dec 2017, In: BMJ Open. 7, 12, e018647.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Consensus 100%
  • Information Dissemination 92%
  • Clinical Trials 68%
  • Advisory Committees 55%
  • Data Anonymization 42%
  3 Downloads (Pure)
• 2016

  Effect of escitalopram versus placebo on GR messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression: A secondary outcome analysis from the randomized AGENDA trial

  Knorr, U., Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, U., Vinberg, M. & Kessing, L. V., 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 297-302

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Citalopram 100%
  • Glucocorticoid Receptors 88%
  • Blood Cells 65%
  • Placebos 55%
  • Depression 52%

• Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: The randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial

  Lundby-Christensen, L., Vaag, A., Tarnow, L., Almdal, T. P., Lund, S. S., Wetterslev, J., Gluud, C., Boesgaard, T. W., Wiinberg, N., Perrild, H., Krarup, T., Snorgaard, O., Gade-Rasmussen, B., Thorsteinsson, B., Røder, M., Mathiesen, E. R., Jensen, T., Vestergaard, H., Hedetoft, C., Breum, L., & 6 othersDuun, E., Sneppen, S. B., Pedersen, O., Hemmingsen, B., Carstensen, B. & Madsbad, S., 25. Feb 2016, In: BMJ Open. 6, 2, e008377.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Carotid Intima-Media Thickness 100%
  • Metformin 89%
  • Type 2 Diabetes Mellitus 62%
  • Insulin 56%
  • Insulin Detemir 52%
  1 Downloads (Pure)

• False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review

  Imberger, G., Thorlund, K., Gluud, C. & Wetterslev, J., 12. Aug 2016, In: BMJ Open. 6, 8, e011890.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Meta-Analysis 100%
  • Psychological Power 31%
  • Negative Results 23%
  • Systematic Reviews 16%
  • Numbers Needed To Treat 13%
  6 Downloads (Pure)

• Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus-the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial

  Lundby-Christensen, L., Tarnow, L., Boesgaard, T. W., Lund, S. S., Wiinberg, N., Perrild, H., Krarup, T., Snorgaard, O., Gade-Rasmussen, B., Thorsteinsson, B., Røder, M., Mathiesen, E. R., Jensen, T., Vestergaard, H., Hedetoft, C., Breum, L., Duun, E., Sneppen, S. B., Pedersen, O., Hemmingsen, B., & 6 othersCarstensen, B., Madsbad, S., Gluud, C., Wetterslev, J., Vaag, A. & Almdal, T. P., 25. Feb 2016, In: BMJ Open. 6, 2, e008376.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Metformin 100%
  • Type 2 Diabetes Mellitus 69%
  • Placebos 64%
  • Carotid Intima-Media Thickness 63%
  • Insulin 63%
  5 Downloads (Pure)

• Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

  Koster, G., Bekema, H. J., Wetterslev, J., Gluud, C., Keus, F. & van der Horst, I. C. C., 1. Sep 2016, In: Intensive Care Medicine. 42, 9, p. 1322-1335 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Milrinone 100%
  • Critical Illness 64%
  • Meta-Analysis 51%
  • Systematic Reviews 50%
  • Randomized Controlled Trials 46%
  6 Downloads (Pure)

• The CHANGE trial: No superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity

  Speyer, H., Christian Brix Nørgaard, H., Birk, M., Karlsen, M., Storch Jakobsen, A., Pedersen, K., Hjorthøj, C., Pisinger, C., Gluud, C., Mors, O., Krogh, J. & Nordentoft, M., Jun 2016, In: World Psychiatry. 15, 2, p. 155-165

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Equivalence Trials 100%
  • Abdominal Obesity 84%
  • Mentoring 82%
  • Life Style 61%
  • Schizophrenia 61%
• 2015

  Count data analysis in randomised clinical trials

  Jakobsen, J. C., Tamborrino, M., Winkel, P., Haase, N., Perner, A., Wetterslev, J. & Gluud, C., 2015, In: Journal of Biometrics & Biostatistics. 6, 2, 5 p., 1000227.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Effects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis

  Koster, G., Wetterslev, J., Gluud, C., Zijlstra, J. G., Scheeren, T. W. L., van der Horst, I. C. C. & Keus, F., Feb 2015, In: Intensive Care Medicine. 41, 2, p. 203-221

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Simendan 100%
  • Low Cardiac Output 87%
  • Critical Illness 61%
  • Meta-Analysis 49%
  • Systematic Reviews 48%

• Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis

  Volbeda, M., Wetterslev, J., Gluud, C., Zijlstra, J. G., van der Horst, I. C. C. & Keus, F., Jul 2015, In: Intensive Care Medicine. 41, 7, p. 1220-1234

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Sepsis 100%
  • Meta-Analysis 92%
  • Systematic Reviews 91%
  • Steroids 66%
  • Confidence Intervals 52%
  4 Downloads (Pure)

• Simulation-based multiprofessional obstetric anaesthesia training conducted in situ versus off-site leads to similar individual and team outcomes: A randomised educational trial

  Sørensen, J. L., Van Der Vleuten, C., Rosthøj, S., Østergaard, D., LeBlanc, V., Johansen, M., Ekelund, K., Starkopf, L., Lindschou, J., Gluud, C., Weikop, P. & Ottesen, B., 6. Oct 2015, In: BMJ Open. 5, 10, e008344.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Obstetrical Anesthesia 100%
  • Organizational Innovation 71%
  • Motivation 55%
  • Patient Safety 51%
  • Anesthesiology 42%
  4 Downloads (Pure)
• 2014

  Mammalian target of rapamycin inhibitors for heart transplant patients

  Penninga, E. I., Møller, C. H., Gustafsson, F., Gluud, C. & Penninga, L., 19. Sep 2014, In: Cochrane Database of Systematic Reviews. 2014, 9, CD011206.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • TOR Serine-Threonine Kinases 100%
  • Heart 58%
  • Transplants 56%
  • Immunosuppressive Agents 44%
  • Calcineurin Inhibitors 21%
• 2013

  Is the Total Score of the Hamilton Depression Rating Scale Associated with Suicide Attempts or Suicides?

  Christian Jakobsen, J., Simonsen, E., Buch Rasmussen, K. & Gluud, C., 2013, In: British Journal of Medicine and Medical Research. 3, 1, p. 140-152

  Research output: Contribution to journal › Journal article › Research › peer-review

• The Necessity of Randomized Clinical Trials

  Christian Jakobsen, J. & Gluud, C., 2013, In: British Journal of Medicine and Medical Research. 3, 4, p. 1453-1468

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2012

  General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine

  Golubnitschaja, O., Costigliola, V., Gluud, C. & EPMA, 1. Nov 2012, In: EPMA Journal. 3, 1, 14.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Preventive Medicine 100%
  • Precision Medicine 93%
  • Industry 63%
  • medicine 62%
  • Integrative Medicine 42%
  2 Downloads (Pure)

• La riflessione dell'EMA sul placebo non riflette gli interessi dei pazienti

  Translated title of the contribution: The EMA's deliberation on placebos does not reflect patients' interestsBanzi, R., Bertele, V., Gluud, C. & Garattini, S., Jul 2012, In: Ricerca e Pratica. 28, 4, p. 179-189

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2011

  Danish contributions to the evaluation of serum therapy for diphtheria in the 1890s

  Gluud, C., May 2011, In: Journal of the Royal Society of Medicine. 105, 7, p. 219-222

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2010

  Graft patency after off-pump versus on-pump coronary artery surgery in high-risk patients

  Møller, C. H., Perko, M. J., Lund, J. T., Andersen, L. W., Kelbæk, H., Madsen, J. K., Gluud, C. & Steinbrchel, D. A., 2010, In: Scandinavian Cardiovascular Journal. 44, 3, p. 161-167

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronary Vessels 100%
  • Transplants 76%
  • Coronary Artery Bypass 25%
  • Angiography 10%
  • Clinical Trials 8%
• 2009

  Assessment of risk of bias in randomized clinical trials in surgery

  Gurusamy, K. S., Gluud, C., Nikolova, D. & Davidson, B. R., Apr 2009, In: British Journal of Surgery. 96, 4, p. 342-349

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Risk Assessment 100%
  • Randomized Controlled Trials 80%
  • Meta-Analysis 14%

• Pegylated interferon alpha 2a versus pegylated interferon alpha 2b for chronic hepatitis C

  Awad, T., Thorlund, K., Hauser, G., Mabrouk, M., Stimac, D. & Gluud, C., 2009, In: Cochrane Database of Systematic Reviews. CD005642.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2007

  Intervention med clarithromycin hos patienter med stabil iskæmisk hjertesygdom: CLARICOR-forsøget - Sekundærpublikation

  Translated title of the contribution: Intervention with clarithromycin in patients with stable coronary heart disease--the CLARICOR trial: secondary publicationgruppen, CLARICOR., Kolmos, H. J. & Gluud, C., 5. Feb 2007, In: Ugeskrift for læger. 169, 6, p. 497-499 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clarithromycin 100%
  • Coronary Disease 74%
  • Publications 69%
  • Anti-Bacterial Agents 36%
  • Placebos 19%
• 2005

  High-dose antioxidants to prevent cancer: Hype or hoax?

  Bjelakovic, G., Nikolova, D., Simonetti, R. G., Gluud, C. & Sagar, S. M., Mar 2005, In: Focus on Alternative and Complementary Therapies. 10, 1, p. 29-31

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2004

  Hospital doctors' self-rated skills in and use of evidence-based medicine - A questionnaire survey

  Oliveri, R. S., Gluud, C. & Wille-Jørgensen, P. A., May 2004, In: Journal of Evaluation in Clinical Practice. 10, 2, p. 219-226

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Evidence-Based Medicine 100%
  • medicine 63%
  • questionnaire 44%
  • evidence 36%
  • Libraries 29%

• Subtotal hysterectomy increased the risk of urinary incontinence compared to total hysterectomy

  Gimbel, H., Zobbe, V., Andersen, B. M., Filtenberg, T., Gluud, C., Tabor, A., Addis, I. B. & Brown, J. S., Jun 2004, In: Evidence-based Obstetrics and Gynecology. 6, 2, p. 79-80 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Treatment of hepatic encephalopathy: Authors' reply

  Als-Nielsen, B., Gluud, L. L. & Gluud, C., 10. Jul 2004, In: BMJ. 329, 7457, p. 112

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1998

  Quality assessment of reports on clinical trials in the Journal of Hepatology

  Gluud, C. & Nikolova, D., Aug 1998, In: Journal of Hepatology. 29, 2, p. 321-327

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gastroenterology 100%
  • Randomized Controlled Trials 60%
  • Clinical Trials 57%
  • MEDLINE 25%
  • Intention to Treat Analysis 17%
• 1994

  The mallory body: Morphological, clinical and experimental studies (part 1 of a literature survey)

  Jensen, K. & Gluud, C., Oct 1994, In: Hepatology. 20, 4, p. 1061-1077

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mallory Bodies 100%
  • Clinical Studies 42%
  • Alcoholic Hepatitis 13%
  • Alcohols 10%
  • Intermediate Filaments 10%
• 1991

  Hepatic effects of dietary weight loss in morbidly obese subjects

  Andersen, T., Gluud, C., Franzmann, M. B. & Christoffersen, P., Mar 1991, In: Journal of Hepatology. 12, 2, p. 224-229

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Weight Loss 100%
  • Fibrosis 67%
  • Liver 62%
  • Formulated Food 42%
  • Caloric Restriction 38%
• 1987

  Liver haemodynamics and function in alcoholic cirrhosis. Relation to testosterone treatment and ethanol consumption

  Gluud, C. & Henriksen, J. H., 1987, In: Journal of Hepatology. 4, 2, p. 168-173

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Alcoholic Liver Cirrhosis 100%
  • Testosterone 67%
  • Ethanol 64%
  • Hemodynamics 56%
  • Liver 39%
• 1986

  Testosterone treatment of men with alcoholic cirrhosis: A double‐blind study

  Gluud, C. & The Copenhagen Study Group for Liver Diseases, 1986, In: Hepatology. 6, 5, p. 807-813

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Alcoholic Liver Cirrhosis 100%
  • Testosterone 67%
  • Placebos 29%
  • Biochemistry 15%
  • Therapeutics 12%
• 1985

  Autoimmunity in liver diseases: Agressor or ally?

  Gluud, C., 1985, In: Annales de Biologie Clinique. 43, 4, p. 444-449 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1982

  Mortality after acute hepatitis type a, b, and non-a non-b in 981 patients followed up for up to 10 years

  Sørensen, T. I. A., Peter, S., Aldershvile, J., Christoffersen, P., Dietrichson, O., Faber, V., Gluud, C., Hardt, F., Høybye, G., Iversen, K., Juhl, E., Kryger, P., Mathiesen, L., Nielsen, J. O., Orholm, M., Petersen, P., Poulsen, H., Schlichting, P. & Tage-Jensen, U., 1982, In: Scandinavian Journal of Gastroenterology. 17, 2, p. 193-198

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis A 100%
  • Hepatitis 76%
  • Autopsy 68%
  • Liver Diseases 45%
  • Liver 41%
• 1976

  Effect of Glucagon on Cyclic AMP, Albumin Metabolism and Incorporation of ¹⁴C‐Leucine into Proteins in Isolated Parenchymal Rat Liver Cells

  Dich, J. & Gluud, C. N., Aug 1976, In: Acta Physiologica Scandinavica. 97, 4, p. 457-469

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon 100%
  • Cyclic AMP 94%
  • Albumins 82%
  • Liver 49%
  • Proteins 35%