Research Output 1995 2019

2019
14 Downloads (Pure)

Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., Brooks, D. J., Larsen, M. R. & Finsen, B., 31. Oct 2019, In : Scientific Reports. 9, 1, 15 p., 15758.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Alzheimer Disease
Pathology
Tauopathies
Ribosomal RNA
Energy Metabolism
53 Downloads (Pure)

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

Myhre, C. L., Thygesen, C., Villadsen, B., Vollerup, J., Ilkjær, L., Krohn, K. T., Grebing, M., Zhao, S., Khan, A. M., Dissing-Olesen, L., Jensen, M. S., Babcock, A. A. & Finsen, B., 30. Jul 2019, In : Frontiers in cellular neuroscience. 13, 17 p., 308.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Messenger RNA
Tumor Necrosis Factor-alpha
Cell Proliferation
Neurons
17 Downloads (Pure)

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease

Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B., 1. May 2019, In : Alzheimer's Research & Therapy. 11, 1, 38.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Serotonin Plasma Membrane Transport Proteins
Alzheimer Disease
Interleukin-6
Tumor Necrosis Factor-alpha
Serotonin Antagonists
80 Downloads (Pure)

Post-stroke inflammation – target or tool for therapy?

Lambertsen, K. L., Finsen, B. & Clausen, B. H., May 2019, In : Acta Neuropathologica. 137, 5, p. 693-714

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File

Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy

Krøigård, T., Metaxas, A., Wirenfeldt, M. & Finsen, B., Oct 2019, In : Experimental Brain Research. 237, 10, p. 2645-2651

Research output: Contribution to journalJournal articleResearchpeer-review

oxaliplatin
Ibuprofen
Peripheral Nervous System Diseases
Spinal Ganglia
Neuroprotective Agents

Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke

Thygesen, C., Larsen, M. R. & Finsen, B., Jul 2019, In : Expert Review of Proteomics. 16, 7, p. 601-611

Research output: Contribution to journalReviewResearchpeer-review

Alzheimer Disease
Cerebrospinal fluid
Proteins
Cerebrospinal Fluid
Myeloid Cells
25 Downloads (Pure)

TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex

Yli-Karjanmaa, M. L. K., Larsen, K. S., Fenger, C., Kristensen, L. K., Martin, N. A., jensen, P. T., Breton, A., Nathanson, L., Nielsen, P. V., Lund, M. C., Lindeman Carlsen, S., Gramsbergen, J. B., Finsen, B., Stubbe, J., Frich, L. H., Stolp, H., Brambilla, R., anthony, D., Meyer, M. & Lambertsen, K. L., 1. Nov 2019, In : Brain, Behavior, and Immunity. 82, p. 279-297

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Tumor Necrosis Factor-alpha
Neurons
Proteins
Neocortex
2018
Proteome
Alzheimer Disease
Proteins
tau Proteins
Oxidative Phosphorylation

Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 month old APPswe/PSEN1dE9 Mice

Metaxas, A., Vaitheeswaran, R., Jensen, K. T., Thygesen, C., Ilkjaer, L., Darvesh, S. & Finsen, B., 14. Mar 2018, In : Current Alzheimer Research. 15, 5, p. 420-428

Research output: Contribution to journalJournal articleResearchpeer-review

Serotonin Plasma Membrane Transport Proteins
Alzheimer Disease
Messenger RNA
Pathology
Frozen Sections
2017

Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke

Grønhøj, M. B., Clausen, B. H., Fenger, C., Lambertsen, K. L. & Finsen, B., 2017, In : Brain, Behavior, and Immunity. 65, p. 296-311

Research output: Contribution to journalJournal articleResearchpeer-review

Interleukin-6
Middle Cerebral Artery Infarction
Interleukin-6 Receptors
Messenger RNA
Therapeutic Uses

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice

Yoo, J. H., Borsodi, A., Tóth, G., Benyhe, S., Gaspar, R., Matifas, A., Kieffer, B. L., Metaxas, A., Kitchen, I. & Bailey, A., 2017, In : Neuroscience Letters. 643, p. 16-21

Research output: Contribution to journalJournal articleResearchpeer-review

Oxymorphone
Opioid Receptors
Oxycodone
delta Opioid Receptor

Chronic lipopolysaccharide treatment affects cerebral amyloidosis and pathways of inflammation and synaptic plasticity in an APP/PS1 mouse model of Alzheimer's disease"

Ilkjær, L., Thygesen, C., Babcock, A., Kempf, S. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

115 Downloads (Pure)

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Venø, M. T., Venø, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J., 2017, In : Frontiers in Molecular Neuroscience. 10, 10 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
MicroRNAs
Morphogenesis
Embryonic Structures
Neurons

"Highly increased expression of astrocytic cytokine in neocortex of Alzheimer’s patients investigated by proteomics"

Thygesen, C., Kempf, S., Metaxas, A., Darvesh, S., Larsen, M. R. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

96 Downloads (Pure)

Interleukin-6 is increased in plasma and cerebrospinal fluid of community-dwelling domestic dogs with acute ischaemic stroke

Gredal, H., Thomsen, B. B., Boza-Serrano, A., Garosi, L., Rusbridge, C., anthony, D., Møller, A., Finsen, B., Deierborg, T., Lambertsen, K. L. & Berendt, M., 2017, In : NeuroReport. 28, 3, p. 134-140

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Normalization of Neurofilament Light Chain levels in the CSF after treatment with Dimethyl fimarate.

Mathiesen, T. S., Nielsen, H. H., Ravnborg, M. & Illés, Z., 25. Oct 2017.

Research output: Contribution to conference without publisher/journalPosterResearch

Post-transcriptional regulation of tumor necrosis factor and other microglial-produced cytokines

Jensen, K. T., Nielsen, H. H., Kjems, J. & Finsen, B., 24. May 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

213 Downloads (Pure)

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice

von Linstow, C. U., Waider, J., Grebing, M., Metaxas, A., Lesch, K. P. & Finsen, B., 2017, In : Alzheimer's Research & Therapy. 9, 12 p., 74.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Citalopram
Neocortex
Alzheimer Disease
Serotonin Uptake Inhibitors
Pathology
230 Downloads (Pure)

Spontaneous ischaemic stroke lesions in a dog brain: Neuropathological characterisation and comparison to human ischaemic stroke

Thomsen, B. B., Gredal, H., Nielsen, M. W., Kristensen, B. W., Clausen, B. H., larsen, A. E., Finsen, B., Berendt, M. & Lambertsen, K. L., 2017, In : Acta Veterinaria Scandinavica (Online Edition). 59, 9 p., 7.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., 8. Jul 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., larsen, A. E., Babcock, A. & Darvesh, S., 2017, In : Glia. 65, S1, p. E202-E203 T05-074C .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris

Jensen, K. T., Davidsen, L. I., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris.

Jensen, K. T., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

286 Downloads (Pure)

TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics

Jensen, P., Myhre, C. L., Lassen, P., Metaxas, A., Khan, A. M., Lambertsen, K. L., Babcock, A., Finsen, B., Larsen, M. R. & Kempf, S., 2017, In : OncoTarget. 8, 36, p. 60223-60242

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2016

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thöne-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlöf, B., Hallberg, A., Unger, T. & Steckelings, U. M., 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966

Research output: Contribution to journalJournal articleResearchpeer-review

Angiotensin Type 2 Receptor
Middle Cerebral Artery Infarction
Brain-Derived Neurotrophic Factor
GAP-43 Protein
trkB Receptor
138 Downloads (Pure)

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

Kempf, S. J., Metaxas, A., Ibáñez-Vea, M., Darvesh, S., Finsen, B. & Larsen, M. R., 7. Jun 2016, In : Oncotarget. 7, 23, p. 33627-33648

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Olfactory Bulb
Neocortex
Alzheimer Disease
Long-Term Potentiation
Proteome

A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica

Gebregiworgis, T., Nielsen, H. H., Massilamany, C., Gangaplara, A., Reddy, J., Illes, Z. & Powers, R., 5. Feb 2016, In : Journal of Proteome Research. 15, 2, p. 659-66 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Neuromyelitis Optica
Metabolites
Urine
Biomarkers
Metabolism
146 Downloads (Pure)

Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment

Olesen, L. Ø., Bouzinova, E. V., Severino, M., Sivasaravanaparan, M., Hasselstrøm, J. B., Finsen, B. & Wiborg, O., 2016, In : PLOS ONE. 11, 11, 21 p., e0165144.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Paroxetine
long term effects
Alzheimer disease
Alzheimer Disease
phenotype

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Deierborg, T. & Finsen, B., 2016, In : Acta Neuropathologica. 131, 5, p. 775-91

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Interleukin-1 Receptors
Microglia
Neuroprotective Agents

Chronic, systemic LPS treatment reduces cortical Aβ levels in APP/PS1 Tg mice of two backgrounds

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

109 Downloads (Pure)

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Clausen, B. H., Degn, M., Sivasaravanaparan, M., Fogtmann, T., Andersen, M. G., Trojanowsky, M. D., Gao, H., Hvidsten, S., Baun, C., Deierborg, T., Finsen, B., Kristensen, B. W., Bak, S. T., Meyer, M., Lee, J., Nedospasov, S. A., Brambilla, R. & Lambertsen, K. L., 7. Jul 2016, In : Scientific Reports. 6, 29291.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Dérivés d'acide fumarique á usage médical

Translated title of the contribution: Fumaric acid derivatives for medical useIllés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, IPC No. WO2016074684 A1, Patent No. PCT/DK2015/050344, 19. May 2016, Priority date 11. Nov 2014, Priority No. 62/078,05

Research output: PatentResearch

Effect of ageing and ALzheimner-like pathology on the brain monoaminergic system.

von Linstow, C. U., Severino, M., Metaxas, A., Waider, J., Lesch, K-P., Gramsbergen, J. B. & Finsen, B., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Elucidation of the brain inflammatory network in an APP/PS1 mouse model of Alzheimer disease

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

Examination of Alzheimer’s-related positive, negative and reactive pathology in the brainstem of APPswe/PS1ΔE9 mice

Finsen, B., Jul 2016. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

Pathology
Serotonin Plasma Membrane Transport Proteins
Messenger RNA
Alzheimer Disease
Interleukin-6

Fumaric acid for derivatives for medical use

Illés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, Patent No. WO2016074684 (A1), 19. May 2016, Priority date 11. Nov 2014, Priority No. US201462078051P

Research output: PatentResearch

Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia

Dionne, N., Dib, S., Finsen, B., Denarier, E., Kuhlmann, T., Drouin, R., Kokoeva, M., Hudson, T. J., Siminovitch, K., Friedman, H. C. & Peterson, A. C., 2016, In : Glia. 64, 1, p. 175–194

Research output: Contribution to journalJournal articleResearchpeer-review

Oligodendroglia
Neuroglia
Myelin Sheath
DNA Footprinting
Myelin Basic Protein

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

Madsen, P. M., Clausen, B. H., Degn, M., Thyssen, S., Kristensen, L. K., Svensson, M., Ditzel, N., Finsen, B., Deierborg, T., Brambilla, R. & Lambertsen, K. L., 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 9, p. 1553-69

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Tumor Necrosis Factor-alpha
Membranes
Neuroprotection
Interleukin-6
Chemokine CXCL10
73 Downloads (Pure)

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

Bøttger, P., Glerup, S., Gesslein, B., Illarionova, N. B., Isaksen, T. J., Heuck, A., Clausen, B. H., Füchtbauer, E-M., Gramsbergen, J. B., Gunnarson, E., Aperia, A., Lauritzen, M., Lambertsen, K. L., Nissen, P. & Lykke-Hartmann, K., 25. Feb 2016, In : Scientific Reports. 6, 21 p., 22047.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Hudbiopsi og kvantitativ sensorisk testning kan bidrage til diagnostik af småfiberpolyneuropati

Translated title of the contribution: Skin biopsy and quantitative sensory testing can contribute to small fibre neuropathy diagnosticsKrøigård, T., Karlsson, P., Finnerup, N. B., Sindrup, S. H. & Jensen, T. S., 20. Jun 2016, In : Ugeskrift for Laeger. 178, 19, p. 2-6 V02160134.

Research output: Contribution to journalJournal articleResearchpeer-review

Skin
Nerve Endings
Nerve Fibers
165 Downloads (Pure)

Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study

Gaist, D., Garde, E., Blaabjerg, M., Nielsen, H. H., Krøigård, T., Østergaard, K., Møller, H. S., Hjelmborg, J., Madsen, C. G., Iversen, P., Kyvik, K. O., Siebner, H. R. & Ashina, M., 2016, In : Brain. 139, p. 2015-2023

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Migraine with Aura
Confidence Intervals
Population
White Matter
Registries

Migraine with aura and risk of silent brain infarcts and white matter hyperintensities in women: A population-based MRI-study of Danish twins

Gaist, D., Garde, E., Blaabjerg, M., Nielsen, H. H., Krøigård, T., Østergaard, K., Møller, H., Hjelmborg, J. V. B., Madsen, C. G., Iversen, P., Kyvik, K. O., Siebner, H. R. & Ashina, M., 29. May 2016, In : European Journal of Neurology. 23, Suppl. 1, p. 80 1 p., O2208.

Research output: Contribution to journalConference abstract in journalResearch

Open Access

Myelin-specific T cells induce interleukin-1beta expression in lesion-reactive microglial-like cells in zones of axonal degeneration

Grebing, M., Nielsen, H. H., Fenger, C. D., T Jensen, K., von Linstow, C. U., Clausen, B. H., Söderman, A. M., Lambertsen, K. L., Thomassen, M., Kruse, T. A. & Finsen, B., 2016, In : Glia. 64, 3, p. 407-424

Research output: Contribution to journalJournal articleResearchpeer-review

Myelin Sheath
Interleukin-1beta
Microglia
Messenger RNA
Interleukin-1 Receptors

Tnf-alpha inhibitor for treating stroke

Lambertsen, K. L., Clausen, B. H. & Meyer, M., 26. May 2016, IPC No. WO2016078672 A1, Patent No. PCT/DK2015/050358, 26. May 2016, Priority date 20. Nov 2014, Priority No. DK20140070728

Research output: PatentResearch

2015

CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus

Bassi, M. R., Kongsgaard, M., Steffensen, M. A., Fenger, C., Rasmussen, M., Skjødt, K., Finsen, B., Stryhn, A., Buus, S., Christensen, J. P. & Thomsen, A. R., 1. Feb 2015, In : Journal of Immunology. 194, 3, p. 1141-53

Research output: Contribution to journalJournal articleResearchpeer-review

Yellow fever virus
Yellow Fever
Yellow Fever Vaccine
Attenuated Vaccines
Virus Replication

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L. & Finsen, B., 12. Mar 2015, In : Brain, Behavior, and Immunity. 48, August, p. 86–101

Research output: Contribution to journalJournal articleResearchpeer-review

Microglia
Interleukin 1 Receptor Antagonist Protein
Alzheimer Disease
Neocortex
Amyloid Plaques

Effect of long-term paroxetine treatment on Ab pathology and microgliosis in the APP swe PS1 ǻE9 mouse model of Alzheimer's disease

Sivasaravanaparan, M., Severino, M., Olesen, L. Ø., Jordan, R. O. T., Bouzinova, E., Babcock, A., Hasselstrom, J., Gramsbergen, J. B., Wiborg, O. & Finsen, B., 2015, In : Glia. 63, S1, p. E181 1 p., T05-39B .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

Inacio, A. R., Liu, Y., Clausen, B. H., Svensson, M., Kucharz, K., Yang, Y., Stankovich, T., Khorooshi, R. M. H., Lambertsen, K. L., Issazadeh-Navikas, S. & Deierborg, T., 2015, In : Journal of Neuroinflammation. 12, 18 p., 211.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Microglial TNF and IL-1 as early disease-modifiers in Alzheimer's-like disease in mice

Ilkjær, L., Babcock, A. & Finsen, B., 2015, In : Glia. 63, S1, p. E52-E53 S20-02 .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., Petzold, G. C. & 17 others, Town, T., Morgan, D., Shinohara, M. L., Perry, V. H., Holmes, C., Bazan, N. G., Brooks, D. J., Hunot, S., Joseph, B., Deigendesch, N., Garaschuk, O., Boddeke, E., Dinarello, C. A., Breitner, J. C., Cole, G. M., Golenbock, D. T. & Kummer, M. P., Apr 2015, In : Lancet Neurology. 14, 4, p. 388-405 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Alzheimer Disease
Microglia
Neuroglia
Proteins