Research Output

2020

Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke

Clausen, B. H., Nielsen, M. W., Høgedal, S. S., Frich, L. H., Nielsen, H. H., Schrøder, H. D., Østergaard, K., Finsen, B., Kristensen, B. W. & Lambertsen, K. L., 5. Jun 2020, In : Acta Neuropathologica Communications. 8, 17 p., 81.

Research output: Contribution to journalJournal articleResearchpeer-review

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The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology

Silva, I. M. S., Assersen, K. B., Willadsen, N. N., Jepsen, J., Artuc, M. & Steckelings, U. M., 22. Jul 2020, In : Experimental Dermatology.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., Brooks, D. J., Larsen, M. R. & Finsen, B., 31. Oct 2019, In : Scientific Reports. 9, 1, 15 p., 15758.

Research output: Contribution to journalJournal articleResearchpeer-review

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Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, E. U., Thygesen, C., Montanana-Rosel, R., Limburg, H. L., Asgari, N., Steckelings, U. M. & Owens, T., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E353-E354

Research output: Contribution to journalConference abstract in journalResearch

Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients

Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A. M., Darvesh, S. & Finsen, B., 5. Dec 2019, In : Frontiers in cellular neuroscience. 13, 8 p., 538.

Research output: Contribution to journalJournal articleResearchpeer-review

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Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

Myhre, C. L., Thygesen, C., Villadsen, B., Vollerup, J., Ilkjær, L., Krohn, K. T., Grebing, M., Zhao, S., Khan, A. M., Dissing-Olesen, L., Jensen, M. S., Babcock, A. A. & Finsen, B., 30. Jul 2019, In : Frontiers in cellular neuroscience. 13, 17 p., 308.

Research output: Contribution to journalJournal articleResearchpeer-review

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Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease

Metaxas, A., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M. & Finsen, B., 1. May 2019, In : Alzheimer's Research & Therapy. 11, 1, 38.

Research output: Contribution to journalJournal articleResearchpeer-review

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Post-stroke inflammation – target or tool for therapy?

Lambertsen, K. L., Finsen, B. & Clausen, B. H., May 2019, In : Acta Neuropathologica. 137, 5, p. 693-714

Research output: Contribution to journalJournal articleResearchpeer-review

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Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy

Krøigård, T., Metaxas, A., Wirenfeldt, M. & Finsen, B., Oct 2019, In : Experimental Brain Research. 237, 10, p. 2645-2651

Research output: Contribution to journalJournal articleResearchpeer-review

Protein profiling of CD11b(+) CNS myeloid cells from aged APP(SWE)/PS1(DE9) and wildtype mice points to the involvement of cathepsin Z in Alzheimer's disease

Thygesen, C., Hemdrup, A. L., Ilkjaer, L., Kempf, S. S., von Linstow, C. U., Babcock, A. A., Darvesh, S., Larsen, M. R. & Finsen, B., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E616-E617

Research output: Contribution to journalConference abstract in journalResearch

Proteomic profiling shows changes in proteins involved in oligodendrocyte differentiation in ceruloplasmin knockout mice

Villadsen, B., Thygesen, C., Grebing, M., Kempf, S. J., Nielsen, H. H., Thomassen, M., Kruse, T. A., Larsen, M. R. & Finsen, B., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E145 1 p.

Research output: Contribution to journalConference abstract in journalResearch

Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke

Thygesen, C., Larsen, M. R. & Finsen, B., Jul 2019, In : Expert Review of Proteomics. 16, 7, p. 601-611

Research output: Contribution to journalJournal articleResearchpeer-review

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TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex

Yli-Karjanmaa, M. L. K., Larsen, K. S., Fenger, C., Kristensen, L. K., Martin, N. A., jensen, P. T., Breton, A., Nathanson, L., Nielsen, P. V., Lund, M. C., Lindeman Carlsen, S., Gramsbergen, J. B., Finsen, B., Stubbe, J., Frich, L. H., Stolp, H., Brambilla, R., anthony, D., Meyer, M. & Lambertsen, K. L., 1. Nov 2019, In : Brain, Behavior, and Immunity. 82, p. 279-297

Research output: Contribution to journalJournal articleResearchpeer-review

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Topical administration of a soluble TNF inhibitor reduces infarct volume after focal cerebral ischemia in mice

Yli-Karjanmaa, M., Clausen, B. H., Degn, M., Novrup, H. G., Ellman, D. G., Szymkowski, D. E., Meyer, M., Brambilla, R. & Lambertsen, K. L., 1. Jul 2019, In : Glia. 67, Suppl. 1, p. E412

Research output: Contribution to journalConference abstract in journalResearch

2018

A2AR antagonism in acute EAE model leads to early and more severe EAE

Nylund, M., Vuorimaa, A., Paavilainen, H., Wlodarczyk, A., Jensen, K., Hukkanen, V., Finsen, B., Owens, T. & Airas, L., 1. Oct 2018, In : Multiple Sclerosis Journal. 24, Suppl. 2, p. 823-824 2 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 month old APPswe/PSEN1dE9 Mice

Metaxas, A., Vaitheeswaran, R., Jensen, K. T., Thygesen, C., Ilkjaer, L., Darvesh, S. & Finsen, B., 14. Mar 2018, In : Current Alzheimer Research. 15, 5, p. 420-428

Research output: Contribution to journalJournal articleResearchpeer-review

2017

Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke

Grønhøj, M. B., Clausen, B. H., Fenger, C., Lambertsen, K. L. & Finsen, B., Oct 2017, In : Brain, Behavior, and Immunity. 65, p. 296-311

Research output: Contribution to journalJournal articleResearchpeer-review

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice

Yoo, J. H., Borsodi, A., Tóth, G., Benyhe, S., Gaspar, R., Matifas, A., Kieffer, B. L., Metaxas, A., Kitchen, I. & Bailey, A., 2017, In : Neuroscience Letters. 643, p. 16-21

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic lipopolysaccharide treatment affects cerebral amyloidosis and pathways of inflammation and synaptic plasticity in an APP/PS1 mouse model of Alzheimer's disease"

Ilkjær, L., Thygesen, C., Babcock, A., Kempf, S. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Venø, M. T., Venø, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J., 2017, In : Frontiers in Molecular Neuroscience. 10, 10 p., 31.

Research output: Contribution to journalJournal articleResearchpeer-review

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"Highly increased expression of astrocytic cytokine in neocortex of Alzheimer’s patients investigated by proteomics"

Thygesen, C., Kempf, S., Metaxas, A., Darvesh, S., Larsen, M. R. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Interleukin-6 is increased in plasma and cerebrospinal fluid of community-dwelling domestic dogs with acute ischaemic stroke

Gredal, H., Thomsen, B. B., Boza-Serrano, A., Garosi, L., Rusbridge, C., anthony, D., Møller, A., Finsen, B., Deierborg, T., Lambertsen, K. L. & Berendt, M., 8. Feb 2017, In : NeuroReport. 28, 3, p. 134-140

Research output: Contribution to journalJournal articleResearchpeer-review

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Normalization of Neurofilament Light Chain levels in the CSF after treatment with Dimethyl fimarate.

Mathiesen, T. S., Nielsen, H. H., Ravnborg, M. & Illés, Z., 25. Oct 2017, In : Multiple Sclerosis Journal. 23, p. 582-583

Research output: Contribution to journalConference abstract in journalResearch

Post-transcriptional regulation of tumor necrosis factor and other microglial-produced cytokines

Jensen, K. T., Nielsen, H. H., Kjems, J. & Finsen, B., 24. May 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice

von Linstow, C. U., Waider, J., Grebing, M., Metaxas, A., Lesch, K. P. & Finsen, B., 12. Sep 2017, In : Alzheimer's Research & Therapy. 9, 12 p., 74.

Research output: Contribution to journalJournal articleResearchpeer-review

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Spontaneous ischaemic stroke lesions in a dog brain: Neuropathological characterisation and comparison to human ischaemic stroke

Thomsen, B. B., Gredal, H., Nielsen, M. W., Kristensen, B. W., Clausen, B. H., larsen, A. E., Finsen, B., Berendt, M. & Lambertsen, K. L., 13. Jan 2017, In : Acta Veterinaria Scandinavica (Online Edition). 59, 9 p., 7.

Research output: Contribution to journalJournal articleResearchpeer-review

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Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., 8. Jul 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Stereological estimation of microglial and neuronal cell numbers in Alzheimer's disease and control brains

Finsen, B., larsen, A. E., Babcock, A. & Darvesh, S., 2017, In : Glia. 65, S1, p. E202-E203 T05-074C .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris

Jensen, K. T., Davidsen, L. I., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

The effect of TNF-blockade on T cell-enhanced microglial clearance of myelin debris.

Jensen, K. T., Grebing, M., Clausen, B. H., Lambertsen, K. L., Nielsen, H. H. & Finsen, B., 2017.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics

Jensen, P., Myhre, C. L., Lassen, P., Metaxas, A., Khan, A. M., Lambertsen, K. L., Babcock, A., Finsen, B., Larsen, M. R. & Kempf, S., 2017, In : OncoTarget. 8, 36, p. 60223-60242

Research output: Contribution to journalJournal articleResearchpeer-review

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2016

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thöne-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlöf, B., Hallberg, A., Unger, T. & Steckelings, U. M., 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966

Research output: Contribution to journalJournal articleResearchpeer-review

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

Kempf, S. J., Metaxas, A., Ibáñez-Vea, M., Darvesh, S., Finsen, B. & Larsen, M. R., 7. Jun 2016, In : Oncotarget. 7, 23, p. 33627-33648

Research output: Contribution to journalJournal articleResearchpeer-review

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A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica

Gebregiworgis, T., Nielsen, H. H., Massilamany, C., Gangaplara, A., Reddy, J., Illes, Z. & Powers, R., 5. Feb 2016, In : Journal of Proteome Research. 15, 2, p. 659-666 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment

Olesen, L. Ø., Bouzinova, E. V., Severino, M., Sivasaravanaparan, M., Hasselstrøm, J. B., Finsen, B. & Wiborg, O., 2016, In : PLOS ONE. 11, 11, 21 p., e0165144.

Research output: Contribution to journalJournal articleResearchpeer-review

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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Nabuurs, R. J. A., Kapoerchan, V. V., Metaxas, A., Hafith, S., de Backer, M., Welling, M. M., Jiskoot, W., van den Nieuwendijk, A. M. C. H., Windhorst, A. D., Overkleeft, H. S., van Buchem, M. A., Overhand, M. & van der Weerd, L., 1. Dec 2016, In : Bioorganic & Medicinal Chemistry. 24, 23, p. 6139-6148 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Deierborg, T. & Finsen, B., 9. Feb 2016, In : Acta Neuropathologica. 131, 5, p. 775-791

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Chronic, systemic LPS treatment reduces cortical Aβ levels in APP/PS1 Tg mice of two backgrounds

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Clausen, B. H., Degn, M., Sivasaravanaparan, M., Fogtmann, T., Andersen, M. G., Trojanowsky, M. D., Gao, H., Hvidsten, S., Baun, C., Deierborg, T., Finsen, B., Kristensen, B. W., Bak, S. T., Meyer, M., Lee, J., Nedospasov, S. A., Brambilla, R. & Lambertsen, K. L., 7. Jul 2016, In : Scientific Reports. 6, 16 p., 29291.

Research output: Contribution to journalJournal articleResearchpeer-review

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Dérivés d'acide fumarique á usage médical

Translated title of the contribution: Fumaric acid derivatives for medical useIllés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, IPC No. WO2016074684 A1, Patent No. PCT/DK2015/050344, 19. May 2016, Priority date 11. Nov 2014, Priority No. 62/078,05

Research output: Patent

Effect of ageing and ALzheimner-like pathology on the brain monoaminergic system.

von Linstow, C. U., Severino, M., Metaxas, A., Waider, J., Lesch, K-P., Gramsbergen, J. B. & Finsen, B., 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Elucidation of the brain inflammatory network in an APP/PS1 mouse model of Alzheimer disease

Thygesen, C., 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

Examination of Alzheimer’s-related positive, negative and reactive pathology in the brainstem of APPswe/PS1ΔE9 mice

Finsen, B., Jul 2016. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

Fumaric acid for derivatives for medical use

Illés, Z., Lambertsen, K. L., Finsen, B., Nielsen, H. H. & Clausen, B. H., 19. May 2016, Patent No. WO2016074684 (A1), 19. May 2016, Priority date 11. Nov 2014, Priority No. US201462078051P

Research output: Patent

Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia

Dionne, N., Dib, S., Finsen, B., Denarier, E., Kuhlmann, T., Drouin, R., Kokoeva, M., Hudson, T. J., Siminovitch, K., Friedman, H. C. & Peterson, A. C., Jan 2016, In : Glia. 64, 1, p. 175–194

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

Madsen, P. M., Clausen, B. H., Degn, M., Thyssen, S., Kristensen, L. K., Svensson, M., Ditzel, N., Finsen, B., Deierborg, T., Brambilla, R. & Lambertsen, K. L., 1. Sep 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 9, p. 1553-1569

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

Bøttger, P., Glerup, S., Gesslein, B., Illarionova, N. B., Isaksen, T. J., Heuck, A., Clausen, B. H., Füchtbauer, E-M., Gramsbergen, J. B., Gunnarson, E., Aperia, A., Lauritzen, M., Lambertsen, K. L., Nissen, P. & Lykke-Hartmann, K., 25. Feb 2016, In : Scientific Reports. 6, 21 p., 22047.

Research output: Contribution to journalJournal articleResearchpeer-review

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Hudbiopsi og kvantitativ sensorisk testning kan bidrage til diagnostik af småfiberpolyneuropati

Translated title of the contribution: Skin biopsy and quantitative sensory testing can contribute to small fibre neuropathy diagnosticsKrøigård, T., Karlsson, P., Finnerup, N. B., Sindrup, S. H. & Jensen, T. S., 20. Jun 2016, In : Ugeskrift for Laeger. 178, 19, p. 2-6 V02160134.

Research output: Contribution to journalJournal articleResearchpeer-review

Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study

Gaist, D., Garde, E., Blaabjerg, M., Nielsen, H. H., Krøigård, T., Østergaard, K., Møller, H. S., Hjelmborg, J., Madsen, C. G., Iversen, P., Kyvik, K. O., Siebner, H. R. & Ashina, M., Jul 2016, In : Brain. 139, 7, p. 2015-2023

Research output: Contribution to journalJournal articleResearchpeer-review

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