Research Output

2020

ARAP1 is an independent prognostic biomarker in older women with ovarian high-grade serous adenocarcinoma receiving first-line platinum-based antineoplastic therapy

On behalf of Academy of Geriatric Cancer Research (AgeCare), 2. Jan 2020, In : Acta Oncologica. 59, 1, p. 40-47

Research output: Contribution to journalJournal articleResearchpeer-review

Augmenting engineered T-cell strategies in solid cancers through epigenetic priming

Nielsen, A. Y., Ormhøj, M., Traynor, S. & Gjerstorff, M. F., 10. Jul 2020, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalJournal articleResearchpeer-review

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

Lotsberg, M. L., Wnuk-Lipinska, K., Terry, S., Tan, T. Z., Lu, N., Trachsel-Moncho, L., Røsland, G. V., Siraji, M. I., Hellesøy, M., Rayford, A., Jacobsen, K., Ditzel, H. J., Vintermyr, O. K., Bivona, T. G., Minna, J., Brekken, R. A., Baguley, B., Micklem, D., Akslen, L. A., Gausdal, G. & 5 others, Simonsen, A., Thiery, J. P., Chouaib, S., Lorens, J. B. & Engelsen, A. S. T., Jun 2020, In : Journal of Thoracic Oncology. 15, 6, p. 973-999

Research output: Contribution to journalJournal articleResearchpeer-review

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Cell-free protein synthesis enables one-pot cascade biotransformation in an aqueous-organic biphasic system

Liu, W. Q., Wu, C., Jewett, M. C. & Li, J., 2020, In : Biotechnology and Bioengineering.

Research output: Contribution to journalComment/debateResearchpeer-review

Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (Oncogene, (2018), 37, 41, (5585-5586), 10.1038/s41388-018-0495-6)

Elias, D., Vever, H., Lænkholm, A. V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., Mar 2020, In : Oncogene. 39, 10, p. 2229-2230

Research output: Contribution to journalComment/debateResearchpeer-review

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Corrigendum to "MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis" [Free Radic. Biol. Med. 139 (2019) 1-15]

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H., Mohammadi, A., Gjerstorff, M. & Baradaran, B., Jan 2020, In : Free Radical Biology & Medicine. 146, p. 402

Research output: Contribution to journalComment/debateResearchpeer-review

Effects of oral butyrate and inulin supplementation on inflammation-induced pyroptosis pathway in type 2 diabetes: A randomized, double-blind, placebo-controlled trial

Roshanravan, N., Alamdari, N. M., Jafarabadi, M. A., Mohammadi, A., Shabestari, B. R., Nasirzadeh, N., Asghari, S., Mansoori, B., Akbarzadeh, M., Ghavami, A., Ghaffari, S. & Ostadrahimi, A., Jul 2020, In : Cytokine. 131, 11 p., 155101.

Research output: Contribution to journalJournal articleResearchpeer-review

Hyaluronic acid-decorated liposomal nanoparticles for targeted delivery of 5-fluorouracil into HT-29 colorectal cancer cells

Mansoori, B., Mohammadi, A., Abedi-Gaballu, F., Abbaspour, S., Ghasabi, M., Yekta, R., Shirjang, S., Dehghan, G., Hamblin, M. R. & Baradaran, B., 28. Jan 2020, In : Journal of Cellular Physiology. 235, 10, p. 6817-6830

Research output: Contribution to journalJournal articleResearchpeer-review

Loneliness, Social Isolation, and Chronic Disease Outcomes

Christiansen, J., Lund, R., Qualter, P., Andersen, C. M., Pedersen, S. S. & Lasgaard, M., 31. Aug 2020, In : Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

Research output: Contribution to journalJournal articleResearchpeer-review

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki, O., Rezaei, Z., Rahmati, M., Vahedi, P., Derakhshani, A., Brunetti, O., Baghbanzadeh, A., Mansoori, B., Silvestris, N. & Baradaran, B., 8. Apr 2020, In : International Journal of Molecular Sciences . 21, 7, 23 p., 2578.

Research output: Contribution to journalJournal articleResearchpeer-review

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miR-330 Regulates Colorectal Cancer Oncogenesis by Targeting BACH1

Shirjang, S., Mansoori, B., Mohammad, A., Shajari, N., Duijf, P. H. G., Najaf, S., Gaballu, F. A., Nofouzi, K. & Baradaran, B., 2020, In : Advanced pharmaceutical bulletin. 10, 3, p. 444-451

Research output: Contribution to journalJournal articleResearchpeer-review

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miR-330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

Mansoori, B., Mohammadi, A., Naghizadeh, S., Gjerstorff, M., Shanehbandi, D., Shirjang, S., Najafi, S., Holmskov, U., Khaze, V., Duijf, P. H. G. & Baradaran, B., Feb 2020, In : Journal of Cellular Physiology. 235, 2, p. 920-931

Research output: Contribution to journalJournal articleResearchpeer-review

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Mortality Following Trajectories of Mobility Limitations: The Modifying Impact of Social Factors

Jørgensen, T. S. H., Siersma, V., Lund, R. & Nilsson, C. J., 1. Mar 2020, In : Journal of Aging and Health. 32, 3-4, p. 134-142

Research output: Contribution to journalJournal articleResearchpeer-review

Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness

Mansoori, B., Duijf, P. H. G., Mohammadi, A., Najafi, S., Roshani, E., Shanehbandi, D., Hajiasgharzadeh, K., Shirjang, S., Ditzel, H. J., Kazemi, T., Mokhtarzadeh, A., Gjerstorff, M. F. & Baradaran, B., 3. Mar 2020, In : Expert Opinion On Therapeutic Targets. 24, 3, p. 255-265

Research output: Contribution to journalJournal articleResearchpeer-review

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

Hubackova, S., Davidova, E., Boukalova, S., Kovarova, J., Bajzikova, M., Coelho, A., Terp, M. G., Ditzel, H. J., Rohlena, J. & Neuzil, J., 1. Feb 2020, In : Cell Death and Disease. 11, 2, 16 p., 110.

Research output: Contribution to journalJournal articleResearchpeer-review

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Simple FRET electrophoresis method for precise and dynamic evaluation of serum siRNA stability

Tuttolomondo, M. & Ditzel, H. J., 17. Jan 2020, In : ACS Medicinal Chemistry Letters. 11, 2, p. 195-202

Research output: Contribution to journalJournal articleResearchpeer-review

The potentials of immune checkpoints for the treatment of blood malignancies

Alizadeh, M., Safarzadeh, A., Hoseini, S. A., Piryaei, R., Mansoori, B., Hajiasgharzadeh, K., Baghbanzadeh, A. & Baradaran, B., Sep 2020, In : Critical Reviews in Oncology/Hematology. 153, 16 p., 103031.

Research output: Contribution to journalJournal articleResearchpeer-review

The role of miR-34 in cancer drug resistance

Naghizadeh, S., Mohammadi, A., Duijf, P. H. G., Baradaran, B., Safarzadeh, E., Cho, W. C. S. & Mansoori, B., 16. Feb 2020, In : Journal of Cellular Physiology. 235, 10, p. 6424-6440

Research output: Contribution to journalJournal articleResearchpeer-review

2019

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In : Cell Death & Disease. 10, 11, 12 p., 841.

Research output: Contribution to journalJournal articleResearchpeer-review

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Annexin A2 and S100A10 as candidate prognostic markers in epithelial ovarian cancer

Christensen, M. V., Høgdall, C., Jensen, S. G., Lokman, N., Ricciardelli, C., Christensen, I. J., Christiansen, P., Brask, J., Karlsen, M. A., Nissen, T. K., Jochumsen, K. M. & Høgdall, E., 1. May 2019, In : Anticancer Research. 39, 5, p. 2475-2482

Research output: Contribution to journalJournal articleResearchpeer-review

Cellular Heterogeneity and Single-Cell Omics

Qian, Z. & Bao, L., 2019, Single-Cell Omics: Technological Advances and Applications. Barh, D. & Azevedo, V. (eds.). Academic Press, Vol. 1. p. 35-44

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Block, I., Müller, C., Sdogati, D., Pedersen, H., List, M., Jaskot, A. M., Syse, S. D., Lund Hansen, P., Schmidt, S., Christiansen, H., Casella, C., Bering Olsen, S., Blomstrøm, M. M., Riedel, A., Thomassen, M., Kruse, T. A., Karlskov Hansen, S. W., Kioschis, P. & Mollenhauer, J., 6. Jun 2019, In : Oncogene. 38, 23, p. 4560-4573

Research output: Contribution to journalJournal articleResearchpeer-review

Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19

Ormhøj, M., Scarfò, I., Cabral, M. L., Bailey, S. R., Lorrey, S. J., Bouffard, A. A., Castano, A. P., Larson, R. C., Riley, L. S., Schmidts, A., Choi, B. D., Andersen, R. S., Cédile, O., Nyvold, C. G., Haaber, J., Gjerstorff, M. F., Ditzel, H. J., Weinstock, D. M., Barington, T., Frigault, M. J. & 1 others, Maus, M. V., 1. Dec 2019, In : Clinical Cancer Research. 25, 23, p. 7046-7057

Research output: Contribution to journalJournal articleResearchpeer-review

CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients

Pedersen, M. H., Hood, B. L., Ehmsen, S., Beck, H. C., Conrads, T. P., Bak, M., Ditzel, H. J. & Leth-Larsen, R., 1. Feb 2019, In : International Journal of Cancer. 144, 3, p. 631-640

Research output: Contribution to journalJournal articleResearchpeer-review

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Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer

Koopman, L. A., Terp, M. G., Zom, G. G., Janmaat, M. L., Jacobsen, K., Van Den Heuvel, E. G., Brandhorst, M., Forssmann, U., De Bree, F., Pencheva, N., Lingnau, A., Zipeto, M. A., Parren, P. W. H. I., Breij, E. C. W. & Ditzel, H. J., Oct 2019, In : JCI Insight. 4, 21, 19 p., e128199.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC

Røsland, G. V., Dyrstad, S. E., Tusubira, D., Helwa, R., Tan, T. Z., Lotsberg, M. L., Pettersen, I. K. N., Berg, A., Kindt, C., Hoel, F., Jacobsen, K., Arason, A. J., Engelsen, A. S. T., Ditzel, H. J., Lønning, P. E., Krakstad, C., Thiery, J. P., Lorens, J. B., Knappskog, S. & Tronstad, K. J., 1. Jun 2019, In : Cancer & Metabolism. 7, 18 p., 6.

Research output: Contribution to journalJournal articleResearchpeer-review

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HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy

Mansoori, B., Mohammadi, A., Asadzadeh, Z., Shirjang, S., Minouei, M., Abedi Gaballu, F., Shajari, N., Kazemi, T., Gjerstrorff, M. F., Duijf, P. H. G. & Baradaran, B., Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17714-17726

Research output: Contribution to journalJournal articleResearchpeer-review

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Identification of miRNAs correlating with stage and progression of colorectal cancer

Asadi, M., Talesh, S. T., Gjerstorff, M. F., Shanehbandi, D., Baradaran, B., Hashemzadeh, S. & Zafari, V., 1. Nov 2019, In : Colorectal Cancer. 8, 2, 10 p., CRC06.

Research output: Contribution to journalJournal articleResearchpeer-review

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Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

Ehmsen, S., Pedersen, M. H., Wang, G., Terp, M. G., Arslanagic, A., Hood, B. L., Conrads, T. P., Leth-Larsen, R. & Ditzel, H. J., 25. Jun 2019, In : Cell Reports. 27, 13, p. 3927-3938.e6

Research output: Contribution to journalJournal articleResearchpeer-review

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MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H. G., Mohammadi, A., Gjerstorff, M. & Baradaran, B., 1. Aug 2019, In : Free Radical Biology & Medicine. 139, p. 1-15

Research output: Contribution to journalJournal articleResearchpeer-review

miR-142-3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach-1 expression

Mansoori, B., Mohammadi, A., Ghasabi, M., Shirjang, S., Dehghan, R., Montazeri, V., Holmskov, U., Kazemi, T., Duijf, P., Gjerstorff, M. & Baradaran, B., Jun 2019, In : Journal of Cellular Physiology. 234, 6, p. 9816-9825

Research output: Contribution to journalJournal articleResearchpeer-review

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miR-142-3p is a tumor suppressor that inhibits estrogen receptor expression in ER-positive breast cancer

Mansoori, B., Mohammadi, A., Gjerstorff, M. F., Shirjang, S., Asadzadeh, Z., Khaze, V., Holmskov, U., Kazemi, T., Duijf, P. H. G. & Baradaran, B., 1. Sep 2019, In : Journal of Cellular Physiology. 234, 9, p. 16043-16053

Research output: Contribution to journalJournal articleResearchpeer-review

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Optimization of NGS-based 16S rRNA gene sequencing for identification of bacterial pathogens in clinical samples

Høgh, S. V., Larsen, S. L., Kemp, M., Skov, M. N., Sydenham, T. V., Johansen, R. L., Arnborg Didreksen, S. & Johansson Nielsen, E., 17. Oct 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Photodynamic therapy for cancer: Role of natural products

Mansoori, B., Mohammadi, A., Amin Doustvandi, M., Mohammadnejad, F., Kamari, F., Gjerstorff, M. F., Baradaran, B. & Hamblin, M. R., Jun 2019, In : Photodiagnosis and Photodynamic Therapy. 26, p. 395-404

Research output: Contribution to journalJournal articleResearchpeer-review

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Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

Traynor, S., Møllegaard, N. E., Jørgensen, M. G., Brückmann, N. H., Pedersen, C. B., Terp, M. G., Johansen, S., Dejardin, J., Ditzel, H. J. & Gjerstorff, M. F., 26. Jul 2019, In : Nucleic acids research. 47, 13, p. 6668-6684

Research output: Contribution to journalJournal articleResearchpeer-review

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Targeting CD79b with chimeric antigen receptors shows potent pre-clinical efficacy in mantle cell lymphoma

Ormhøj, M., Scarfò, I., Andersen, R. S., Cédile, O., Bailey, S. R., Lorrey, S., Bouffard, A. A., Castano, A. P., Nyvold, C. G., Christensen, J. H., Gjerstorff, M., Ditzel, H., Weinstock, D. M., Barington, T. & Maus, M. V., 14. Feb 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2018

An AXL-specific antibody-drug conjugate shows preclinical anti-tumor activity in non-small cell lung cancer, including EGFR-inhibitor resistant NSCLC

Koopman, L. A., Janmaat, M. L., Jacobsen, K., Terp, M. G., Gresnigt-van den Heuvel, E., Forssman, U., Lingnau, A., Parren, P. W., Ditzel, H. & Breij, E. C., Jul 2018, In : Cancer research. 78, Suppl. 13, 832.

Research output: Contribution to journalConference abstract in journalResearch

Coexisting genomic aberrations associated with lymph node metastasis in breast cancer

Bao, L., Qian, Z., Lyng, M. B., Wang, L., Yu, Y., Wang, T., Zhang, X., Yang, H., Brünner, N., Wang, J. & Ditzel, H. J., 1. Jun 2018, In : Journal of Clinical Investigation. 128, 6, p. 2310-2324

Research output: Contribution to journalJournal articleResearchpeer-review

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Correction to: Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy (Oncogene, (2015), 34, 15, (1919-1927), 10.1038/onc.2014.138)

Elias, D., Vever, H., Lænkholm, A. V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., Oct 2018, In : Oncogene. 37, 41, p. 5585–5586

Research output: Contribution to journalComment/debateResearchpeer-review

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Correlation between circulating cell-free PIK3CA tumor DNA levels and treatment response in patients with PIK3CA-mutated metastatic breast cancer

Kodahl, A. R., Ehmsen, S., Pallisgaard, N., Jylling, A. M. B., Jensen, J. D., Lænkholm, A. V., Knoop, A. S. & Ditzel, H. J., Jun 2018, In : Molecular Oncology. 12, 6, p. 925-935

Research output: Contribution to journalJournal articleResearchpeer-review

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Epigenetic reprogramming of pericentromeric satellite DNA in premalignant and malignant lesions

Brückmann, N. H., Pedersen, C. B., Ditzel, H. J. & Gjerstorff, M. F., Mar 2018, In : Molecular Cancer Research. 16, 3, p. 417-427

Research output: Contribution to journalJournal articleResearchpeer-review

Human cancer evolution in the context of a human immune system in mice

Gammelgaard, O. L., Terp, M. G., Preiss, B. & Ditzel, H. J., Oct 2018, In : Molecular Oncology. 12, 10, p. 1797-1810

Research output: Contribution to journalJournal articleResearchpeer-review

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Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers

Hansen, S. V., Traynor, S., Ditzel, H. J. & Gjerstorff, M. F., 1. Oct 2018, In : PLOS ONE. 13, 10, 13 p., e0205461.

Research output: Contribution to journalJournal articleResearchpeer-review

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KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer

Wang, W., Oguz, G., Lee, P. L., Bao, Y., Wang, P., Terp, M. G., Ditzel, H. J. & Yu, Q., 5. Nov 2018, In : The Journal of Experimental Medicine. 215, 11, p. 2833-2849

Research output: Contribution to journalJournal articleResearchpeer-review

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One-step FPLC-size-exclusion chromatography procedure for purification of rDMBT1 6 kb with increased biological activity

Tuttolomondo, M., Hansen, P. L., Mollenhauer, J. & Ditzel, H. J., 1. Feb 2018, In : Analytical Biochemistry. 542, p. 16-19

Research output: Contribution to journalJournal articleResearchpeer-review

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Proteomic comparison of clinical breast cancer samples, corresponding patient derived xenografts (PDX) and mammospheres reveal increased cholesterol biosynthesis as a key feature of cancer stem cells

Ehmsen, S., Pedersen, M. H., Arslanagic, A., Terp, M. G., Leth-Larsen, R., Ditzel, H., Hood, B. L. & Conrads, T. P., 4. May 2018.

Research output: Contribution to conference without publisher/journalPosterCommunication

Selective elimination of senescent cells by mitochondrial targeting is regulated via ANT2

Davidova, E., Hubackova, S., Rohlenova, K., Stursa, J., Werner, L., Andera, L., Dong, L., Terp, M. G., Hodny, Z., Ditzel, H. J., Rohlena, J. & Neuzil, J., 1. Jun 2018, In : European Journal of Clinical Investigation. 48, Suppl. 1, p. 53-54 2 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2017

Bispecific antibodies targeting human CD73

Ditzel, H. & Gammelgaard, O. L., 13. Jul 2017, Patent No. WO2017118613 (A1), 13. Jul 2017, Priority date 8. Jan 2016, Priority No. EP20160150669

Research output: Patent

CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells

Peipp, M., Wesch, D., Oberg, H. H., Lutz, S., Muskulus, A., van de Winkel, J. G. J., Parren, P. W. H. I., Burger, R., Humpe, A., Kabelitz, D., Gramatzki, M. & Kellner, C., Oct 2017, In : Scandinavian Journal of Immunology. 86, 4, p. 196-206

Research output: Contribution to journalJournal articleResearchpeer-review

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