Novel Voltage-Sensing Mechanisms in Biology, derived from Principles of Soft Matter Physics

Impact: Other impact

Description of impact

Health: The physiological impact of voltage-sensing is wide, and spans hearing, pain, heat sensation, and transmission of the action potential in nerves, energy storage and signaling. Using the design principles that we discover, we will search for such sensors in membrane proteins, potentially unmasking an entirely new voltage-sensing mechanism in ICs, which of course, are major drug targets for a large variety of diseases and neurological disorders such as serious cardiac arrhythmia, diabetes, cystic fibrosis and atherosclerosis
Category of impactOther impact