Nanotechnology and contact allergy - a risk not to be overlooked.

Jakob Torp Madsen (Lecturer)

Activity: Talks and presentationsTalks and presentations in private or public companies

Description

Introduction

Liposomes and nanoparticles are used increasingly in the cosmetic and pharmaceutical industry. The benefits of encapsulating chemicals in vesicles regarding topical products include increased delivery of active ingredients to or through the skin, protecting products from degradation, and giving improved cosmetic performance. The impact of encapsulating chemicals in carrier molecules on allergic contact dermatitis is unknown. When active ingredients are formulated in carriers such as polycaprolactone, ethosomes or liposomes, this could theoretically increase the sensitization and elicitation potential due to increased bioavailability and skin penetration properties. Few case reports support that the increased bioavailability obtained with encapsulation of chemicals in carrier molecules increases allergenicity.

 

Methods

Ethosomes and liposomes were produced and loaded with the fragrance allergen isoeugenol as well as potassium dichromate. The sensitization portential of ethosome preparations were compared with isoeugenol solution in the same concentrations using the Local Lymph Node Assay (LLNA).

 

Results

Isoeugenol encapsulated in ethosomes significantly increased the sensitizing potency in the LLNA. On the other hand, encapsulated potassium dichromate decreased the sensitizing potency in the LLNA.

 

Conclusion

The results reveal that the allergenic potency of chemicals may be affected by encapsulating allergens in carrier molecules.
Period14. Jun 2009
Event typeConference
LocationEdingburgh, United Kingdom