X-ray reflectivity investgation of structure and kinetics of photoswitchable lipid monolayers

Kuntal Chatterjee, Björn Haushahn, Chen Shen, Sven Festersen, Jonas Warias, Benjamin Runge, Franziska Reise, Thisbe Lindhorst, Beate Maria Klösgen-Buchkremer, Olaf M. Magnussen, Bridget Murphy

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Abstrakt

The mechanical and dynamic properties of phospholipid membranes are of importance for important biological functions, such as switching of embedded proteins. In order to investigate these properties we study model systems in which amphiphilic photoswitchable molecules are integrated into Langmuir films of phospholipids. we have modified glycolipids to contain an azobenzene photoswitch between the chain and the head group and successfully embedded those in a monolayer of dipalmitoylphosphatidylcholine (DPPC). This allows us to reversibly change the azobenzene-glycolipid orientation between trans- and cis-conformation by illumination with UV and blue light. We have followed the structural changes in this model membrane and the switching kinetics of the system with Langmuir isotherms and in situ X-ray reflectivity at the LISA diffractometer P08, PETRA III.
OriginalsprogEngelsk
Publikationsdatomar. 2016
StatusUdgivet - mar. 2016
Begivenhed80. Jahrestagung der DPG und DPG-Frühjahrstagung: BP: Fachverband Biologische Physik - Regensburg, Tyskland
Varighed: 6. mar. 201611. mar. 2016

Konference

Konference80. Jahrestagung der DPG und DPG-Frühjahrstagung
LandTyskland
ByRegensburg
Periode06/03/201611/03/2016

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