Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

A M Rosendahl Madsen; A Holm; T G Jensen; E Knudsen; H Lundgaard; M N Skov; S A Uldum; M Kemp

doi:10.1016/j.jhin.2017.04.020

Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

A M Rosendahl Madsen, A Holm, T G Jensen, E Knudsen, H Lundgaard, M N Skov, S A Uldum, M Kemp

KI, OUH, Forskningsenhed for Klinisk mikrobiologi (Odense)

Statens Serum Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

Originalsprog	Engelsk
Tidsskrift	Journal of Hospital Infection
Vol/bind	96
Udgave nummer	4
Sider (fra-til)	392-395
ISSN	0195-6701
DOI	https://doi.org/10.1016/j.jhin.2017.04.020
Status	Udgivet - 2017

Dokumenter og links

10.1016/j.jhin.2017.04.020

Citationsformater

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abstract = "Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.",

keywords = "Journal Article",

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T1 - Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

AU - Rosendahl Madsen, A M

AU - Holm, A

AU - Jensen, T G

AU - Knudsen, E

AU - Lundgaard, H

AU - Skov, M N

AU - Uldum, S A

AU - Kemp, M

PY - 2017

Y1 - 2017

N2 - Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

AB - Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.

KW - Journal Article

U2 - 10.1016/j.jhin.2017.04.020

DO - 10.1016/j.jhin.2017.04.020

M3 - Journal article

C2 - 28622979

SN - 0195-6701

VL - 96

SP - 392

EP - 395

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 4

ER -

Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

Abstract

Dokumenter og links

Fingeraftryk

Citationsformater