White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls

Torben Albert Devantier, B. L. Norgaard, Mikael Kjær Poulsen, E Garde, K. A. Ovrehus, M Marwan, S Achenbach, D. Dey, L. H. Sørensen, P Videbech

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Background: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be important for the formation of WMLs in depression. Methods: The case-control study included 29 patients with late-onset major depressive disorder and27 controls matched for sex, age, and tobacco use. WML volume, carotid intima-media thickness, and coronary plaque volume were assessed using magnetic resonance imaging, ultrasound scan, and coronary computed tomography (CT) angiography, respectively. Results: The mean age for the total sample was 59.7 4.7 years. There was no difference in carotid intima-media thickness between patients and controls (p = 0.164), whereas a higher WML volume in the patients was found (p = 0.051). In both patients and controls, WML volume was associated with carotid but not with coronary atherosclerosis. In adjusted multiple linear regression, a 0.1 mm increase in averaged carotid intima-media thickness was associated with a 52% (95% CI: 8.4-112, p = 0.032) increase in WML volume. The association between carotid intima-media thickness and WML volume was, however, similar in patients and controls. Conclusions: In older persons aged between 50 and 70 years, WMLs do not seem to be a part of generalized atherosclerotic disease, but seem to be dependent on atherosclerosis in the carotid arteries. Carotid atherosclerosis, however, could not explain the higher WML load observed in the depressed patients, and thus, studies are needed to establish the mechanisms linking depression and WMLs.
Udgave nummer4
Sider (fra-til)369-377
StatusUdgivet - 2016

Bibliografisk note

ISI Document Delivery No.: DN7XX Times Cited: 0 Cited Reference Count: 30 Devantier, Torben Albert Norgaard, Bjarne Linde Poulsen, Mikael Kjaer Garde, Ellen Ovrehus, Kristian Altern Marwan, Mohamed Achenbach, Stephan Dey, Damini Sorensen, Leif Hougaard Videbech, Poul Danish Ministry of Science, Technology and Innovation; Augustinus Fonden, Copenhagen, Denmark The study was supported by grants from the Danish Ministry of Science, Technology and Innovation, and Augustinus Fonden, Copenhagen, Denmark. 0 1 Elsevier science inc New york


Dyk ned i forskningsemnerne om 'White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls'. Sammen danner de et unikt fingeraftryk.