When the entire population is the sample: strengths and limitations in register-based epidemiology

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Studies based on databases, medical records and registers are used extensively today in epidemiological research. Despite the increasing use, no developed methodological literature on use and evaluation of population-based registers is available, even though data collection in register-based studies differs from researcher-collected data, all persons in a population are available and traditional statistical analyses focusing on sampling error as the main source of uncertainty may not be relevant. We present the main strengths and limitations of register-based studies, biases especially important in register-based studies and methods for evaluating completeness and validity of registers. The main strengths are that data already exist and valuable time has passed, complete study populations minimizing selection bias and independently collected data. Main limitations are that necessary information may be unavailable, data collection is not done by the researcher, confounder information is lacking, missing information on data quality, truncation at start of follow-up making it difficult to differentiate between prevalent and incident cases and the risk of data dredging. We conclude that epidemiological studies with inclusion of all persons in a population followed for decades available relatively fast are important data sources for modern epidemiology, but it is important to acknowledge the data limitations.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind29
Udgave nummer8
Sider (fra-til)551-558
ISSN0393-2990
DOI
StatusUdgivet - 10. jan. 2014

Fingeraftryk

Epidemiology
Selection Bias
Research Personnel
Population
Information Storage and Retrieval
Uncertainty
Medical Records
Registries
Epidemiologic Studies
Databases
Research
Data Accuracy

Citer dette

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abstract = "Studies based on databases, medical records and registers are used extensively today in epidemiological research. Despite the increasing use, no developed methodological literature on use and evaluation of population-based registers is available, even though data collection in register-based studies differs from researcher-collected data, all persons in a population are available and traditional statistical analyses focusing on sampling error as the main source of uncertainty may not be relevant. We present the main strengths and limitations of register-based studies, biases especially important in register-based studies and methods for evaluating completeness and validity of registers. The main strengths are that data already exist and valuable time has passed, complete study populations minimizing selection bias and independently collected data. Main limitations are that necessary information may be unavailable, data collection is not done by the researcher, confounder information is lacking, missing information on data quality, truncation at start of follow-up making it difficult to differentiate between prevalent and incident cases and the risk of data dredging. We conclude that epidemiological studies with inclusion of all persons in a population followed for decades available relatively fast are important data sources for modern epidemiology, but it is important to acknowledge the data limitations.",
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When the entire population is the sample : strengths and limitations in register-based epidemiology. / Thygesen, Lau Caspar; Ersbøll, Annette Kjær.

I: European Journal of Epidemiology, Bind 29, Nr. 8, 10.01.2014, s. 551-558.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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