Weight change and risk of hyperglycaemia in elderly women

Katrine Dragsbæk, Jesper S Neergaard, Claus Christiansen, Morten A Karsdal, Henning Beck-Nielsen, Susanne Brix, Kim Henriksen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood.

AIM: We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women.

METHODS: Elderly Caucasian women (age: 67.1 years at baseline, n = 1173) enrolled in the Prospective Epidemiological Risk Factor study with baseline and 13-year follow-up measurements of BMI and fasting glucose levels (FPG) and no previous history of diabetes or impaired fasting glucose. Multivariate logistic regression was used to determine risk of hyperglycaemia (FPG ≥ 5.6 mmol/L or HbA1c ≥ 42 mmol/mol) in normalweight (BMI ≤ 25 kg/m(2)), overweight (BMI = 25-29.9 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)) women who either lost weight, were weight-stable or had gained weight at follow-up.

RESULTS: Overweight and obese elderly women who had gained weight at follow-up presented an increased risk of hyperglycaemia, OR = 2.7 (1.6-4.6) and OR = 3.2 (1.5-6.8), compared to weight-stable normalweight women. Overweight and obese women who lost weight decreased their risk of hyperglycaemia to a level comparable to weight-stable normalweight women. Overweight and obese women with stable weight presented a two-fold increased risk of hyperglycaemia compared to normalweight weight-stable women.

CONCLUSIONS: Losing weight in late life had a positive effect on the risk of hyperglycaemia in overweight and obese women, while further, weight gain increased the risk of hyperglycaemia. The study highlights that strategies to reduce weight in obese and overweight elderly women could have a positive influence on disease burden in late-life.

OriginalsprogEngelsk
TidsskriftAging Clinical and Experimental Research
Vol/bind29
Udgave nummer6
Sider (fra-til)1095–1104
ISSN1594-0667
DOI
StatusUdgivet - 2017

Fingeraftryk

Hyperglycemia
Weights and Measures
Fasting
Type 2 Diabetes Mellitus
Weight Gain
Logistic Models

Citer dette

Dragsbæk, Katrine ; Neergaard, Jesper S ; Christiansen, Claus ; Karsdal, Morten A ; Beck-Nielsen, Henning ; Brix, Susanne ; Henriksen, Kim. / Weight change and risk of hyperglycaemia in elderly women. I: Aging Clinical and Experimental Research. 2017 ; Bind 29, Nr. 6. s. 1095–1104.
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title = "Weight change and risk of hyperglycaemia in elderly women",
abstract = "BACKGROUND: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood.AIM: We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women.METHODS: Elderly Caucasian women (age: 67.1 years at baseline, n = 1173) enrolled in the Prospective Epidemiological Risk Factor study with baseline and 13-year follow-up measurements of BMI and fasting glucose levels (FPG) and no previous history of diabetes or impaired fasting glucose. Multivariate logistic regression was used to determine risk of hyperglycaemia (FPG ≥ 5.6 mmol/L or HbA1c ≥ 42 mmol/mol) in normalweight (BMI ≤ 25 kg/m(2)), overweight (BMI = 25-29.9 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)) women who either lost weight, were weight-stable or had gained weight at follow-up.RESULTS: Overweight and obese elderly women who had gained weight at follow-up presented an increased risk of hyperglycaemia, OR = 2.7 (1.6-4.6) and OR = 3.2 (1.5-6.8), compared to weight-stable normalweight women. Overweight and obese women who lost weight decreased their risk of hyperglycaemia to a level comparable to weight-stable normalweight women. Overweight and obese women with stable weight presented a two-fold increased risk of hyperglycaemia compared to normalweight weight-stable women.CONCLUSIONS: Losing weight in late life had a positive effect on the risk of hyperglycaemia in overweight and obese women, while further, weight gain increased the risk of hyperglycaemia. The study highlights that strategies to reduce weight in obese and overweight elderly women could have a positive influence on disease burden in late-life.",
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Dragsbæk, K, Neergaard, JS, Christiansen, C, Karsdal, MA, Beck-Nielsen, H, Brix, S & Henriksen, K 2017, 'Weight change and risk of hyperglycaemia in elderly women', Aging Clinical and Experimental Research, bind 29, nr. 6, s. 1095–1104. https://doi.org/10.1007/s40520-016-0696-1

Weight change and risk of hyperglycaemia in elderly women. / Dragsbæk, Katrine; Neergaard, Jesper S; Christiansen, Claus; Karsdal, Morten A; Beck-Nielsen, Henning; Brix, Susanne; Henriksen, Kim.

I: Aging Clinical and Experimental Research, Bind 29, Nr. 6, 2017, s. 1095–1104.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Weight change and risk of hyperglycaemia in elderly women

AU - Dragsbæk, Katrine

AU - Neergaard, Jesper S

AU - Christiansen, Claus

AU - Karsdal, Morten A

AU - Beck-Nielsen, Henning

AU - Brix, Susanne

AU - Henriksen, Kim

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood.AIM: We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women.METHODS: Elderly Caucasian women (age: 67.1 years at baseline, n = 1173) enrolled in the Prospective Epidemiological Risk Factor study with baseline and 13-year follow-up measurements of BMI and fasting glucose levels (FPG) and no previous history of diabetes or impaired fasting glucose. Multivariate logistic regression was used to determine risk of hyperglycaemia (FPG ≥ 5.6 mmol/L or HbA1c ≥ 42 mmol/mol) in normalweight (BMI ≤ 25 kg/m(2)), overweight (BMI = 25-29.9 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)) women who either lost weight, were weight-stable or had gained weight at follow-up.RESULTS: Overweight and obese elderly women who had gained weight at follow-up presented an increased risk of hyperglycaemia, OR = 2.7 (1.6-4.6) and OR = 3.2 (1.5-6.8), compared to weight-stable normalweight women. Overweight and obese women who lost weight decreased their risk of hyperglycaemia to a level comparable to weight-stable normalweight women. Overweight and obese women with stable weight presented a two-fold increased risk of hyperglycaemia compared to normalweight weight-stable women.CONCLUSIONS: Losing weight in late life had a positive effect on the risk of hyperglycaemia in overweight and obese women, while further, weight gain increased the risk of hyperglycaemia. The study highlights that strategies to reduce weight in obese and overweight elderly women could have a positive influence on disease burden in late-life.

AB - BACKGROUND: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood.AIM: We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women.METHODS: Elderly Caucasian women (age: 67.1 years at baseline, n = 1173) enrolled in the Prospective Epidemiological Risk Factor study with baseline and 13-year follow-up measurements of BMI and fasting glucose levels (FPG) and no previous history of diabetes or impaired fasting glucose. Multivariate logistic regression was used to determine risk of hyperglycaemia (FPG ≥ 5.6 mmol/L or HbA1c ≥ 42 mmol/mol) in normalweight (BMI ≤ 25 kg/m(2)), overweight (BMI = 25-29.9 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)) women who either lost weight, were weight-stable or had gained weight at follow-up.RESULTS: Overweight and obese elderly women who had gained weight at follow-up presented an increased risk of hyperglycaemia, OR = 2.7 (1.6-4.6) and OR = 3.2 (1.5-6.8), compared to weight-stable normalweight women. Overweight and obese women who lost weight decreased their risk of hyperglycaemia to a level comparable to weight-stable normalweight women. Overweight and obese women with stable weight presented a two-fold increased risk of hyperglycaemia compared to normalweight weight-stable women.CONCLUSIONS: Losing weight in late life had a positive effect on the risk of hyperglycaemia in overweight and obese women, while further, weight gain increased the risk of hyperglycaemia. The study highlights that strategies to reduce weight in obese and overweight elderly women could have a positive influence on disease burden in late-life.

KW - Journal Article

U2 - 10.1007/s40520-016-0696-1

DO - 10.1007/s40520-016-0696-1

M3 - Journal article

C2 - 28265973

VL - 29

SP - 1095

EP - 1104

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

SN - 1594-0667

IS - 6

ER -