TY - JOUR
T1 - Waist circumference is related to low-grade inflammation in youth
AU - Steene-Johannessen, Jostein
AU - Kolle, Elin
AU - Resaland, GK
AU - Anderssen, Sigmund A
AU - Andersen, Lars Bo
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Abstract Objectives. To examine markers of inflammation in 9- and 15-year-olds with high waist circumference and compare these with controls, and to examine the relationships between inflammatory markers and cardiovascular disease (CVD) risk factors. Methods. Cross-sectional analysis of data from 2 299 Norwegian 9- and 15-year-olds participating in the "Physical activity among Norwegian Children Study". In each sex and age group, the 10 participants with the highest waist circumference (HW) were selected (n=40) for analyses, and a random sample of 40 participants within the same groups were included as controls. Inflammatory markers included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha), hepatocyte growth factor (HGF), resistin and interleukin-6 (IL-6). The CVD risk factors included blood pressure, glucose, insulin, triglycerides and high density lipoprotein cholesterol. Results. HW participants had elevated levels of CRP (mean difference 1.50 mg/l; 95% confidence interval [CI] 0.33 to 2.66), PAI-1 (mean difference 13.3 ng/ml; 95% CI 4.1 to 22.5) and HGF (mean difference 0.29 ng/ml; 95% CI 0.07 to 0.51) compared with controls. All CVD risk factors differed between the HW group and controls. The CVD risk factors were not associated with TNFalpha or IL-6, but CRP, HGF and PAI-1 were related to the metabolic risk score. Conclusions. Low grade systemic inflammation is already present in youth with high waist circumference. CRP, HGF and PAI-1 may be related to the adverse overall metabolic risk profile observed in these children and adolescents.
AB - Abstract Objectives. To examine markers of inflammation in 9- and 15-year-olds with high waist circumference and compare these with controls, and to examine the relationships between inflammatory markers and cardiovascular disease (CVD) risk factors. Methods. Cross-sectional analysis of data from 2 299 Norwegian 9- and 15-year-olds participating in the "Physical activity among Norwegian Children Study". In each sex and age group, the 10 participants with the highest waist circumference (HW) were selected (n=40) for analyses, and a random sample of 40 participants within the same groups were included as controls. Inflammatory markers included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha), hepatocyte growth factor (HGF), resistin and interleukin-6 (IL-6). The CVD risk factors included blood pressure, glucose, insulin, triglycerides and high density lipoprotein cholesterol. Results. HW participants had elevated levels of CRP (mean difference 1.50 mg/l; 95% confidence interval [CI] 0.33 to 2.66), PAI-1 (mean difference 13.3 ng/ml; 95% CI 4.1 to 22.5) and HGF (mean difference 0.29 ng/ml; 95% CI 0.07 to 0.51) compared with controls. All CVD risk factors differed between the HW group and controls. The CVD risk factors were not associated with TNFalpha or IL-6, but CRP, HGF and PAI-1 were related to the metabolic risk score. Conclusions. Low grade systemic inflammation is already present in youth with high waist circumference. CRP, HGF and PAI-1 may be related to the adverse overall metabolic risk profile observed in these children and adolescents.
U2 - 10.3109/17477160903497035
DO - 10.3109/17477160903497035
M3 - Journal article
C2 - 20078378
SN - 2047-6302
VL - 5
SP - 313
EP - 319
JO - International Journal of Pediatric Obesity
JF - International Journal of Pediatric Obesity
IS - 4
ER -