Resumé
BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.
MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.
RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).
CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European journal of gastroenterology & hepatology |
| Vol/bind | 30 |
| Udgave nummer | 11 |
| Sider (fra-til) | 1297–1303 |
| ISSN | 0954-691X |
| DOI | |
| Status | Udgivet - nov. 2018 |
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Vitamin D deficiency in a European inflammatory bowel disease inception cohort : an Epi-IBD study. / Zammit, Stefania Chetcuti; Ellul, Pierre; Girardin, Giulia; Valpiani, Daniela; Nielsen, Kári R; Olsen, Jóngerð; Goldis, Adrian; Lazar, Daniela; Shonová, Olga; Nováková, Marie; Sebastian, Shaji; Whitehead, Emma; Carmona, Amalia; Martinez-Cadilla, Jesus; Dahlerup, Jens F; Kievit, Adriana L H; Thorsgaard, Niels; Katsanos, Konstantinos H; Christodoulou, Dimitrios K; Magro, Fernando; Salupere, Riina; Pedersen, Natalia; Kjeldsen, Jens; Carlsen, Katrine; Ioannis, Kaimaklioti; Bergemalm, Daniel; Halfvarson, Jonas; Duricova, Dana; Bortlik, Martin; Collin, Pekka; Oksanen, Pia; Kiudelis, Gediminas; Kupcinskas, Limas; Kudsk, Karen; Andersen, Vibeke; O'Morain, Colm; Bailey, Yvonne; Doron, Schwartz; Shmuel, Odes; Almer, Sven; Arebi, Naila; Misra, Ravi; Čuković-Čavka, Silvija; Brinar, Marko; Munkholm, Pia; Vegh, Zsuzsanna; Burisch, Johan.
I: European journal of gastroenterology & hepatology, Bind 30, Nr. 11, 11.2018, s. 1297–1303.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Vitamin D deficiency in a European inflammatory bowel disease inception cohort
T2 - an Epi-IBD study
AU - Zammit, Stefania Chetcuti
AU - Ellul, Pierre
AU - Girardin, Giulia
AU - Valpiani, Daniela
AU - Nielsen, Kári R
AU - Olsen, Jóngerð
AU - Goldis, Adrian
AU - Lazar, Daniela
AU - Shonová, Olga
AU - Nováková, Marie
AU - Sebastian, Shaji
AU - Whitehead, Emma
AU - Carmona, Amalia
AU - Martinez-Cadilla, Jesus
AU - Dahlerup, Jens F
AU - Kievit, Adriana L H
AU - Thorsgaard, Niels
AU - Katsanos, Konstantinos H
AU - Christodoulou, Dimitrios K
AU - Magro, Fernando
AU - Salupere, Riina
AU - Pedersen, Natalia
AU - Kjeldsen, Jens
AU - Carlsen, Katrine
AU - Ioannis, Kaimaklioti
AU - Bergemalm, Daniel
AU - Halfvarson, Jonas
AU - Duricova, Dana
AU - Bortlik, Martin
AU - Collin, Pekka
AU - Oksanen, Pia
AU - Kiudelis, Gediminas
AU - Kupcinskas, Limas
AU - Kudsk, Karen
AU - Andersen, Vibeke
AU - O'Morain, Colm
AU - Bailey, Yvonne
AU - Doron, Schwartz
AU - Shmuel, Odes
AU - Almer, Sven
AU - Arebi, Naila
AU - Misra, Ravi
AU - Čuković-Čavka, Silvija
AU - Brinar, Marko
AU - Munkholm, Pia
AU - Vegh, Zsuzsanna
AU - Burisch, Johan
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
AB - BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
KW - Adolescent
KW - Adrenal Cortex Hormones/therapeutic use
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Anti-Inflammatory Agents/therapeutic use
KW - Biomarkers/blood
KW - Child
KW - Europe/epidemiology
KW - Female
KW - Humans
KW - Inflammatory Bowel Diseases/diagnosis
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Quality of Life
KW - Risk Factors
KW - Severity of Illness Index
KW - Smoking/adverse effects
KW - Time Factors
KW - Vitamin D Deficiency/blood
KW - Vitamin D/blood
KW - Young Adult
U2 - 10.1097/MEG.0000000000001238
DO - 10.1097/MEG.0000000000001238
M3 - Journal article
VL - 30
SP - 1297
EP - 1303
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 11
ER -