We live in a changed world. In times past many resources could be found in abundance: intellectual, financial, social and natural capital domains alike. Population growth was generally slow and total human population was well below the carrying capacity of the planet. In such times, enterprise consideration for social and environmental performance was generally quite low and the upper boundaries of those considerations were generally by legal or other external means, rather by an internal conscience. Times have changed, with positive and negative elements of change. Many of the social, environmental, and enterprise challenges that enterprises and we as individuals are confronted by are far too large, with consequences far too extreme to be approached without help. Rapid, highly-innovative, and highly-productive collaboration is needed. A key pre-condition for such collaboration is trust, with higher trust levels leading to higher levels of cyclical virtuous or positive reciprocal behaviour. Explored are the relationships among trust, reciprocal behaviour, leadership, and collaboration with respect to innovation and enterprise excellence.