Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

Nynne Dose, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Christina Ellervik, Peter R Hansen, Jørgen K Kanters, Eva Prescott, Steering Committee of the iPOWER study, Jens Kastrup, Ida Gustafsson, Henrik Steen Hansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.

METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.

RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).

CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

OriginalsprogEngelsk
TidsskriftJournal of Electrocardiology
Vol/bind51
Udgave nummer1
Sider (fra-til)15-20
ISSN0022-0736
DOI
StatusUdgivet - 1. jan. 2018

Fingeraftryk Dyk ned i forskningsemnerne om 'Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction'. Sammen danner de et unikt fingeraftryk.

  • Citationsformater

    Dose, N., Michelsen, M. M., Mygind, N. D., Pena, A., Ellervik, C., Hansen, P. R., Kanters, J. K., Prescott, E., Steering Committee of the iPOWER study, Kastrup, J., Gustafsson, I., & Hansen, H. S. (2018). Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction. Journal of Electrocardiology, 51(1), 15-20. https://doi.org/10.1016/j.jelectrocard.2017.08.017