Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women

Christine Dalgård, Lene Christiansen, Ulla Birgitte Vogel, Claus Dethlefsen, Anne Tjønneland, Kim Overvad

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.

DESIGN: In the Danish Diet, Cancer and Health cohort study, we performed a case-cohort study among 57,053 subjects aged 50-64 years.

RESULTS: During a mean follow-up period of 6.4 years, we identified 936 cases and randomly selected a sub-cohort (n = 1,580) with full information on genotypes and covariates. Using Cox proportional hazard models, we found that women with the rs6139591 TT genotype and a lower than median dietary vitamin C intake had a higher risk of acute coronary syndrome compared with those with the CC genotype (adjusted HR 5.39, 95% confidence interval, 2.01-14.50). We also observed a not as strong but positive although inconsistent association for women at a higher than median intake of vitamin C rich food. For the rs1776964 polymorphism, we found a higher risk (adjusted HR 3.45, 95% CI, 1.16-10.28) among TT-homozygous women with higher than median vitamin C intake compared with the CC genotype and low vitamin C intake. Among men, weaker and non-significant associations were observed for both polymorphisms.

CONCLUSION: Genetic variation in the sodium-dependent vitamin C transporter 2 is associated with risk of incident acute coronary syndrome in women. The genotype effects may not be fully compensated by a higher intake of vitamin C rich food.
OriginalsprogEngelsk
Artikelnummere70421
TidsskriftPLOS ONE
Vol/bind8
Udgave nummer8
ISSN1932-6203
DOI
StatusUdgivet - 2013

Fingeraftryk

Sodium-Coupled Vitamin C Transporters
Acute Coronary Syndrome
Ascorbic Acid
transporters
Genes
ascorbic acid
sodium
genes
Collagen
Tissue
collagen
Proteins
synthesis

Citer dette

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Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women. / Dalgård, Christine; Christiansen, Lene; Vogel, Ulla Birgitte; Dethlefsen, Claus; Tjønneland, Anne; Overvad, Kim.

I: PLOS ONE, Bind 8, Nr. 8, e70421, 2013.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Tjønneland, Anne

AU - Overvad, Kim

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