Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

G Rose; S Dato; K Altomare; D Bellizzi; S Garasto; V Greco; G Passarino; E Feraco; V Mari; C Barbi; M BonaFe; C Franceschi; Qihua Tan; S Boiko; AI Yashin; G Benedictis

doi:10.1016/S0531-5565(03)00209-2

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

G Rose
, S Dato
, K Altomare
, D Bellizzi
, S Garasto
, V Greco
, G Passarino
, E Feraco
, V Mari
, C Barbi
, M BonaFe
, C Franceschi
, Qihua Tan
, S Boiko
, AI Yashin
, G Benedictis

Unknown

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

Originalsprog	Engelsk
Tidsskrift	Experimental Gerontology
Vol/bind	38
Udgave nummer	10
Sider (fra-til)	1065-70
Antal sider	6
ISSN	0531-5565
DOI	https://doi.org/10.1016/S0531-5565(03)00209-2
Status	Udgivet - okt. 2003
Udgivet eksternt	Ja

Dokumenter og links

10.1016/S0531-5565(03)00209-2

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V., Passarino, G., Feraco, E., Mari, V., Barbi, C., BonaFe, M., Franceschi, C., Tan, Q., Boiko, S., Yashin, AI., & Benedictis, G. (2003). Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Experimental Gerontology, 38(10), 1065-70. https://doi.org/10.1016/S0531-5565(03)00209-2

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title = "Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly",

abstract = "The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.",

author = "G Rose and S Dato and K Altomare and D Bellizzi and S Garasto and V Greco and G Passarino and E Feraco and V Mari and C Barbi and M BonaFe and C Franceschi and Qihua Tan and S Boiko and AI Yashin and G Benedictis",

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doi = "10.1016/S0531-5565(03)00209-2",

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Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, AI & Benedictis, G 2003, 'Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly', Experimental Gerontology, bind 38, nr. 10, s. 1065-70. https://doi.org/10.1016/S0531-5565(03)00209-2

TY - JOUR

T1 - Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

AU - Rose, G

AU - Dato, S

AU - Altomare, K

AU - Bellizzi, D

AU - Garasto, S

AU - Greco, V

AU - Passarino, G

AU - Feraco, E

AU - Mari, V

AU - Barbi, C

AU - BonaFe, M

AU - Franceschi, C

AU - Tan, Qihua

AU - Boiko, S

AU - Yashin, AI

AU - Benedictis, G

PY - 2003/10

Y1 - 2003/10

N2 - The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

AB - The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

U2 - 10.1016/S0531-5565(03)00209-2

DO - 10.1016/S0531-5565(03)00209-2

M3 - Journal article

SN - 0531-5565

VL - 38

SP - 1065

EP - 1070

JO - Experimental Gerontology

JF - Experimental Gerontology

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ER -