Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

G Rose, S Dato, K Altomare, D Bellizzi, S Garasto, V Greco, G Passarino, E Feraco, V Mari, C Barbi, M BonaFe, C Franceschi, Qihua Tan, S Boiko, AI Yashin, G Benedictis

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Resumé

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.
OriginalsprogEngelsk
TidsskriftExperimental Gerontology
Vol/bind38
Udgave nummer10
Sider (fra-til)1065-70
Antal sider6
ISSN0531-5565
DOI
StatusUdgivet - okt. 2003
Udgivet eksterntJa

Citer dette

Rose, G ; Dato, S ; Altomare, K ; Bellizzi, D ; Garasto, S ; Greco, V ; Passarino, G ; Feraco, E ; Mari, V ; Barbi, C ; BonaFe, M ; Franceschi, C ; Tan, Qihua ; Boiko, S ; Yashin, AI ; Benedictis, G. / Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. I: Experimental Gerontology. 2003 ; Bind 38, Nr. 10. s. 1065-70.
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title = "Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly",
abstract = "The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.",
author = "G Rose and S Dato and K Altomare and D Bellizzi and S Garasto and V Greco and G Passarino and E Feraco and V Mari and C Barbi and M BonaFe and C Franceschi and Qihua Tan and S Boiko and AI Yashin and G Benedictis",
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Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, AI & Benedictis, G 2003, 'Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly', Experimental Gerontology, bind 38, nr. 10, s. 1065-70. https://doi.org/10.1016/S0531-5565(03)00209-2

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. / Rose, G; Dato, S; Altomare, K; Bellizzi, D; Garasto, S; Greco, V; Passarino, G; Feraco, E; Mari, V; Barbi, C; BonaFe, M; Franceschi, C; Tan, Qihua; Boiko, S; Yashin, AI; Benedictis, G.

I: Experimental Gerontology, Bind 38, Nr. 10, 10.2003, s. 1065-70.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

AU - Rose, G

AU - Dato, S

AU - Altomare, K

AU - Bellizzi, D

AU - Garasto, S

AU - Greco, V

AU - Passarino, G

AU - Feraco, E

AU - Mari, V

AU - Barbi, C

AU - BonaFe, M

AU - Franceschi, C

AU - Tan, Qihua

AU - Boiko, S

AU - Yashin, AI

AU - Benedictis, G

PY - 2003/10

Y1 - 2003/10

N2 - The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

AB - The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

U2 - 10.1016/S0531-5565(03)00209-2

DO - 10.1016/S0531-5565(03)00209-2

M3 - Journal article

VL - 38

SP - 1065

EP - 1070

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 10

ER -