Valproic acid monotherapy in pregnancy and major congenital malformations

Janneke Jentink, Maria A Loane, Helen Dolk, Ingeborg Barisic, Ester Garne, Joan K Morris, Lolkje T W de Jong-van den Berg, EUROCAT Antiepileptic Study Working Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited.
OriginalsprogEngelsk
TidsskriftThe New England Journal of Medicine
Vol/bind362
Udgave nummer23
Sider (fra-til)2185-93
Antal sider9
ISSN0028-4793
DOI
StatusUdgivet - 10. jun. 2010

Fingeraftryk

Valproic Acid
Spinal Dysraphism
First Pregnancy Trimester

Citer dette

Jentink, J., Loane, M. A., Dolk, H., Barisic, I., Garne, E., Morris, J. K., ... EUROCAT Antiepileptic Study Working Group (2010). Valproic acid monotherapy in pregnancy and major congenital malformations. The New England Journal of Medicine, 362(23), 2185-93. https://doi.org/10.1056/NEJMoa0907328
Jentink, Janneke ; Loane, Maria A ; Dolk, Helen ; Barisic, Ingeborg ; Garne, Ester ; Morris, Joan K ; de Jong-van den Berg, Lolkje T W ; EUROCAT Antiepileptic Study Working Group. / Valproic acid monotherapy in pregnancy and major congenital malformations. I: The New England Journal of Medicine. 2010 ; Bind 362, Nr. 23. s. 2185-93.
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Jentink, J, Loane, MA, Dolk, H, Barisic, I, Garne, E, Morris, JK, de Jong-van den Berg, LTW & EUROCAT Antiepileptic Study Working Group 2010, 'Valproic acid monotherapy in pregnancy and major congenital malformations', The New England Journal of Medicine, bind 362, nr. 23, s. 2185-93. https://doi.org/10.1056/NEJMoa0907328

Valproic acid monotherapy in pregnancy and major congenital malformations. / Jentink, Janneke; Loane, Maria A; Dolk, Helen; Barisic, Ingeborg; Garne, Ester; Morris, Joan K; de Jong-van den Berg, Lolkje T W; EUROCAT Antiepileptic Study Working Group.

I: The New England Journal of Medicine, Bind 362, Nr. 23, 10.06.2010, s. 2185-93.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Valproic acid monotherapy in pregnancy and major congenital malformations

AU - Jentink, Janneke

AU - Loane, Maria A

AU - Dolk, Helen

AU - Barisic, Ingeborg

AU - Garne, Ester

AU - Morris, Joan K

AU - de Jong-van den Berg, Lolkje T W

AU - EUROCAT Antiepileptic Study Working Group

N1 - Copyright 2010 Massachusetts Medical Society.

PY - 2010/6/10

Y1 - 2010/6/10

N2 - The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited.

AB - The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited.

KW - Abnormalities, Drug-Induced

KW - Anticonvulsants

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Male

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Trimester, First

KW - Prenatal Exposure Delayed Effects

KW - Prevalence

KW - Risk Factors

KW - Valproic Acid

U2 - 10.1056/NEJMoa0907328

DO - 10.1056/NEJMoa0907328

M3 - Journal article

C2 - 20558369

VL - 362

SP - 2185

EP - 2193

JO - The New England Journal of Medicine

JF - The New England Journal of Medicine

SN - 0028-4793

IS - 23

ER -

Jentink J, Loane MA, Dolk H, Barisic I, Garne E, Morris JK et al. Valproic acid monotherapy in pregnancy and major congenital malformations. The New England Journal of Medicine. 2010 jun 10;362(23):2185-93. https://doi.org/10.1056/NEJMoa0907328