Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells.
OriginalsprogEngelsk
TidsskriftActa pharmacologica et toxicologica
Vol/bind53
Udgave nummer3
Sider (fra-til)245-9
Antal sider5
ISSN0001-6683
StatusUdgivet - 1983

Fingeraftryk

p-Methoxy-N-methylphenethylamine
Mast Cells
Histamine
Rats
Adenosine Triphosphate
Antimycin A
Oligomycins
Deoxyglucose
Lactic Acid
Recovery

Citer dette

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title = "Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80",
abstract = "The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells.",
keywords = "Adenosine Triphosphate, Animals, Histamine Release, Lactates, Lactic Acid, Male, Mast Cells, Rats, Rats, Inbred Strains, p-Methoxy-N-methylphenethylamine",
author = "Torben Johansen",
year = "1983",
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volume = "53",
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journal = "Acta pharmacologica et toxicologica",
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Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80. / Johansen, Torben.

I: Acta pharmacologica et toxicologica, Bind 53, Nr. 3, 1983, s. 245-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80

AU - Johansen, Torben

PY - 1983

Y1 - 1983

N2 - The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells.

AB - The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells.

KW - Adenosine Triphosphate

KW - Animals

KW - Histamine Release

KW - Lactates

KW - Lactic Acid

KW - Male

KW - Mast Cells

KW - Rats

KW - Rats, Inbred Strains

KW - p-Methoxy-N-methylphenethylamine

M3 - Journal article

C2 - 6195889

VL - 53

SP - 245

EP - 249

JO - Acta pharmacologica et toxicologica

JF - Acta pharmacologica et toxicologica

SN - 0001-6683

IS - 3

ER -