Use of soluble TREM2 as non-invasive biomarker for NASH

Jonas Heilskov Graversen; Vineesh Indira Chandran; Søren Kragh Moestrup; Maria Kløjgaard Skytthe; Aleksander Krag; Charlotte Wernberg; MM Lauridsen

Use of soluble TREM2 as non-invasive biomarker for NASH

Jonas Heilskov Graversen (Opfinder)
, Vineesh Indira Chandran (Opfinder)
, Søren Kragh Moestrup (Opfinder)
, Maria Kløjgaard Skytthe (Opfinder)
, Aleksander Krag (Opfinder)
, Charlotte Wernberg (Opfinder)
, MM Lauridsen (Opfinder)

Publikation: Patent

Abstract

Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

Originalsprog	Engelsk
IPC	G01N33/68
Patentnummer	WO2022248363 (A1)
Land/Område	Danmark
Prioritetsdato	28/05/2021
Prioritetsnummer	EP20210176575
Status	Udgivet - 1. dec. 2022

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Use of soluble TREM2 as non-invasive biomarker for NASH",

abstract = "Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.",

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T1 - Use of soluble TREM2 as non-invasive biomarker for NASH

AU - Graversen, Jonas Heilskov

AU - Chandran, Vineesh Indira

AU - Moestrup, Søren Kragh

AU - Skytthe, Maria Kløjgaard

AU - Krag, Aleksander

AU - Wernberg, Charlotte

AU - Lauridsen, MM

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

AB - Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.

M3 - Patent

M1 - WO2022248363 (A1)

ER -

Use of soluble TREM2 as non-invasive biomarker for NASH

Abstract

SDU link

Fingeraftryk

Citationsformater