Use of prescription drugs in the older adult population

a nationwide pharmacoepidemiological study

Line Due Christensen*, Mette Reilev, Helle Gybel Juul-Larsen, Lillian Mørch Jørgensen, Susanne Kaae, Ove Andersen, Anton Pottegård, Janne Petersen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Purpose: Multi-morbidity and polypharmacy are common among older people. It is essential to provide a better understanding of the complexity of prescription drug use among older adults to optimise rational pharmacotherapy. Population-based utilisation data in this age group is limited. Using the Danish nationwide health registries, we aimed to characterise drug use among Danish individuals ≥ 60 years. Methods: This is a descriptive population-based study assessing drug prescription patterns in 2015 in the full Danish population aged ≥ 60 years. The use of specific therapeutic subgroups and chemical subgroups and its dependence on age were described using descriptive statistics. Profiles of drug combination patterns were evaluated using latent class analysis. Results: We included 1,424,775 residents (median age 70 years, 53% women). Of all the older adults, 89% filled at least one prescription during 2015. The median number of drug groups used was five per person. The most used single drug groups were paracetamol and analogues (34%), statins (33%) and platelet aggregation inhibitors (24%). Eighteen drug profiles with different drug combination patterns were identified. One drug profile with expected use of zero drugs and 11 drug profiles expected to receive more than five different therapeutic subgroup drugs were identified. Conclusion: The use of drugs is extensive both at the population level and increasing with age at an individual level. Separating the population into different homogenous groups related to drug use resulted in 18 different drug profiles, of which 11 drug profiles received on average more than five different therapeutic subgroup drugs.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind75
Udgave nummer8
Sider (fra-til)1125-1133
ISSN0031-6970
DOI
StatusUdgivet - aug. 2019

Fingeraftryk

Pharmaceutical Preparations
Population
Drug Combinations
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Platelet Aggregation Inhibitors
Therapeutic Uses
Acetaminophen
Prescriptions
Registries
Age Groups
Health

Citer dette

Christensen, L. D., Reilev, M., Juul-Larsen, H. G., Jørgensen, L. M., Kaae, S., Andersen, O., ... Petersen, J. (2019). Use of prescription drugs in the older adult population: a nationwide pharmacoepidemiological study. European Journal of Clinical Pharmacology, 75(8), 1125-1133. https://doi.org/10.1007/s00228-019-02669-2
Christensen, Line Due ; Reilev, Mette ; Juul-Larsen, Helle Gybel ; Jørgensen, Lillian Mørch ; Kaae, Susanne ; Andersen, Ove ; Pottegård, Anton ; Petersen, Janne. / Use of prescription drugs in the older adult population : a nationwide pharmacoepidemiological study. I: European Journal of Clinical Pharmacology. 2019 ; Bind 75, Nr. 8. s. 1125-1133.
@article{02c7e786099a490ca3ac61c61d87e07e,
title = "Use of prescription drugs in the older adult population: a nationwide pharmacoepidemiological study",
abstract = "Purpose: Multi-morbidity and polypharmacy are common among older people. It is essential to provide a better understanding of the complexity of prescription drug use among older adults to optimise rational pharmacotherapy. Population-based utilisation data in this age group is limited. Using the Danish nationwide health registries, we aimed to characterise drug use among Danish individuals ≥ 60 years. Methods: This is a descriptive population-based study assessing drug prescription patterns in 2015 in the full Danish population aged ≥ 60 years. The use of specific therapeutic subgroups and chemical subgroups and its dependence on age were described using descriptive statistics. Profiles of drug combination patterns were evaluated using latent class analysis. Results: We included 1,424,775 residents (median age 70 years, 53{\%} women). Of all the older adults, 89{\%} filled at least one prescription during 2015. The median number of drug groups used was five per person. The most used single drug groups were paracetamol and analogues (34{\%}), statins (33{\%}) and platelet aggregation inhibitors (24{\%}). Eighteen drug profiles with different drug combination patterns were identified. One drug profile with expected use of zero drugs and 11 drug profiles expected to receive more than five different therapeutic subgroup drugs were identified. Conclusion: The use of drugs is extensive both at the population level and increasing with age at an individual level. Separating the population into different homogenous groups related to drug use resulted in 18 different drug profiles, of which 11 drug profiles received on average more than five different therapeutic subgroup drugs.",
keywords = "Drug profiles, Drug utilisation, Older adults, Pharmacoepidemiology, Prescription drugs",
author = "Christensen, {Line Due} and Mette Reilev and Juul-Larsen, {Helle Gybel} and J{\o}rgensen, {Lillian M{\o}rch} and Susanne Kaae and Ove Andersen and Anton Potteg{\aa}rd and Janne Petersen",
year = "2019",
month = "8",
doi = "10.1007/s00228-019-02669-2",
language = "English",
volume = "75",
pages = "1125--1133",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Heinemann",
number = "8",

}

Use of prescription drugs in the older adult population : a nationwide pharmacoepidemiological study. / Christensen, Line Due; Reilev, Mette; Juul-Larsen, Helle Gybel; Jørgensen, Lillian Mørch; Kaae, Susanne; Andersen, Ove; Pottegård, Anton; Petersen, Janne.

I: European Journal of Clinical Pharmacology, Bind 75, Nr. 8, 08.2019, s. 1125-1133.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Use of prescription drugs in the older adult population

T2 - a nationwide pharmacoepidemiological study

AU - Christensen, Line Due

AU - Reilev, Mette

AU - Juul-Larsen, Helle Gybel

AU - Jørgensen, Lillian Mørch

AU - Kaae, Susanne

AU - Andersen, Ove

AU - Pottegård, Anton

AU - Petersen, Janne

PY - 2019/8

Y1 - 2019/8

N2 - Purpose: Multi-morbidity and polypharmacy are common among older people. It is essential to provide a better understanding of the complexity of prescription drug use among older adults to optimise rational pharmacotherapy. Population-based utilisation data in this age group is limited. Using the Danish nationwide health registries, we aimed to characterise drug use among Danish individuals ≥ 60 years. Methods: This is a descriptive population-based study assessing drug prescription patterns in 2015 in the full Danish population aged ≥ 60 years. The use of specific therapeutic subgroups and chemical subgroups and its dependence on age were described using descriptive statistics. Profiles of drug combination patterns were evaluated using latent class analysis. Results: We included 1,424,775 residents (median age 70 years, 53% women). Of all the older adults, 89% filled at least one prescription during 2015. The median number of drug groups used was five per person. The most used single drug groups were paracetamol and analogues (34%), statins (33%) and platelet aggregation inhibitors (24%). Eighteen drug profiles with different drug combination patterns were identified. One drug profile with expected use of zero drugs and 11 drug profiles expected to receive more than five different therapeutic subgroup drugs were identified. Conclusion: The use of drugs is extensive both at the population level and increasing with age at an individual level. Separating the population into different homogenous groups related to drug use resulted in 18 different drug profiles, of which 11 drug profiles received on average more than five different therapeutic subgroup drugs.

AB - Purpose: Multi-morbidity and polypharmacy are common among older people. It is essential to provide a better understanding of the complexity of prescription drug use among older adults to optimise rational pharmacotherapy. Population-based utilisation data in this age group is limited. Using the Danish nationwide health registries, we aimed to characterise drug use among Danish individuals ≥ 60 years. Methods: This is a descriptive population-based study assessing drug prescription patterns in 2015 in the full Danish population aged ≥ 60 years. The use of specific therapeutic subgroups and chemical subgroups and its dependence on age were described using descriptive statistics. Profiles of drug combination patterns were evaluated using latent class analysis. Results: We included 1,424,775 residents (median age 70 years, 53% women). Of all the older adults, 89% filled at least one prescription during 2015. The median number of drug groups used was five per person. The most used single drug groups were paracetamol and analogues (34%), statins (33%) and platelet aggregation inhibitors (24%). Eighteen drug profiles with different drug combination patterns were identified. One drug profile with expected use of zero drugs and 11 drug profiles expected to receive more than five different therapeutic subgroup drugs were identified. Conclusion: The use of drugs is extensive both at the population level and increasing with age at an individual level. Separating the population into different homogenous groups related to drug use resulted in 18 different drug profiles, of which 11 drug profiles received on average more than five different therapeutic subgroup drugs.

KW - Drug profiles

KW - Drug utilisation

KW - Older adults

KW - Pharmacoepidemiology

KW - Prescription drugs

U2 - 10.1007/s00228-019-02669-2

DO - 10.1007/s00228-019-02669-2

M3 - Journal article

VL - 75

SP - 1125

EP - 1133

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 8

ER -