Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

Laura Kofoed Kjær*, Vanja Cejvanovic, Trine Henriksen, Torben Hansen, Oluf Pedersen, Cramer Kjeldahl Christensen, Christian Torp-Pedersen, Thomas Alexander Gerds, Ivan Brandslund, Thomas Mandrup-Poulsen, Henrik Enghusen Poulsen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range: 25–75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI: [0.59–0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95% CI [0.49–0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10–1.53] and OR 1.26, 95% CI [1.07–1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.

OriginalsprogEngelsk
TidsskriftFree Radical Research
Vol/bind53
Udgave nummer6
Sider (fra-til)694-703
ISSN1071-5762
DOI
StatusUdgivet - 4. jun. 2019

Fingeraftryk

Medical problems
Type 2 Diabetes Mellitus
Nucleic Acids
RNA
Oxidation
DNA
Hypoglycemic Agents
Pharmaceutical Preparations
Insulin
Causality
Registries
Logistic Models
Odds Ratio
Lipids
Logistics
Association reactions

Citer dette

Kofoed Kjær, L., Cejvanovic, V., Henriksen, T., Hansen, T., Pedersen, O., Kjeldahl Christensen, C., ... Enghusen Poulsen, H. (2019). Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes. Free Radical Research, 53(6), 694-703. https://doi.org/10.1080/10715762.2019.1622011
Kofoed Kjær, Laura ; Cejvanovic, Vanja ; Henriksen, Trine ; Hansen, Torben ; Pedersen, Oluf ; Kjeldahl Christensen, Cramer ; Torp-Pedersen, Christian ; Alexander Gerds, Thomas ; Brandslund, Ivan ; Mandrup-Poulsen, Thomas ; Enghusen Poulsen, Henrik. / Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes. I: Free Radical Research. 2019 ; Bind 53, Nr. 6. s. 694-703.
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title = "Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes",
abstract = "The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64{\%} male, age range: 25–75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95{\%} CI: [0.59–0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95{\%} CI [0.49–0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95{\%} CI [1.10–1.53] and OR 1.26, 95{\%} CI [1.07–1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.",
keywords = "8-Oxo-7,8-dihydro-2-deoxyguanosine, 8-oxo-7,8-dihydroguanosine, clinical pharmacology, oxidative stress, type 2 diabetes",
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Kofoed Kjær, L, Cejvanovic, V, Henriksen, T, Hansen, T, Pedersen, O, Kjeldahl Christensen, C, Torp-Pedersen, C, Alexander Gerds, T, Brandslund, I, Mandrup-Poulsen, T & Enghusen Poulsen, H 2019, 'Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes', Free Radical Research, bind 53, nr. 6, s. 694-703. https://doi.org/10.1080/10715762.2019.1622011

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes. / Kofoed Kjær, Laura; Cejvanovic, Vanja; Henriksen, Trine; Hansen, Torben; Pedersen, Oluf; Kjeldahl Christensen, Cramer; Torp-Pedersen, Christian; Alexander Gerds, Thomas; Brandslund, Ivan; Mandrup-Poulsen, Thomas; Enghusen Poulsen, Henrik.

I: Free Radical Research, Bind 53, Nr. 6, 04.06.2019, s. 694-703.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

AU - Kofoed Kjær, Laura

AU - Cejvanovic, Vanja

AU - Henriksen, Trine

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Kjeldahl Christensen, Cramer

AU - Torp-Pedersen, Christian

AU - Alexander Gerds, Thomas

AU - Brandslund, Ivan

AU - Mandrup-Poulsen, Thomas

AU - Enghusen Poulsen, Henrik

PY - 2019/6/4

Y1 - 2019/6/4

N2 - The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range: 25–75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI: [0.59–0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95% CI [0.49–0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10–1.53] and OR 1.26, 95% CI [1.07–1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.

AB - The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range: 25–75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI: [0.59–0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin: OR 0.60, 95% CI [0.49–0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10–1.53] and OR 1.26, 95% CI [1.07–1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.

KW - 8-Oxo-7,8-dihydro-2-deoxyguanosine

KW - 8-oxo-7,8-dihydroguanosine

KW - clinical pharmacology

KW - oxidative stress

KW - type 2 diabetes

U2 - 10.1080/10715762.2019.1622011

DO - 10.1080/10715762.2019.1622011

M3 - Journal article

VL - 53

SP - 694

EP - 703

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 6

ER -