Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer

Søren Rafael Rafaelsen, Chris Aksel Vagn-Hansen, Torben Sørensen, Jan Lindebjerg, John Pløen, Anders Jakobsen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Resumé

OBJECTIVE: The current literature has described the usefulness of elastography and diffusion weighted MRI in cancer patients, but to the best of our knowledge so far none of them have compared the two new methods. The tumour cell density is related to the MRI measured apparent diffusion weighted coefficient (ADC). The purpose of the present study was to compare quantitative elastography based on ultrasound shear wave measurements with MRI ADC. METHODS AND MATERIALS: We prospectively examined consecutive 52 patients with histopathological proven rectal cancer. The tumour elasticity was measured using the Acoustic Radiation Force Impulse (ARFI) to generate information on the mechanical properties of the tissue. The objective quantitative elastography shear wave velocity was blindly compared to the ADC measurements using a 1.5 Tesla MRI system. The study was approved by the local Clinical Ethics Committee. RESULTS: The mean tumour elasticity was 3.05 m/s (SD:0.79) and the mean ADC was 0.69 mm2/s (SD: 0.27). Elasticity was inversely strong correlated with ADC, r = -0.65 (Salkin scale). ARFI = 4.392 – 1.949 x ADC, R2 = 0.43, P < 000.1. Intercept = 4.392 (95% CI:3.92 – 4.86), Slope = -1.949 (95% CI: -1.31 - -2.59), P < 0.0001. CONCLUSION: Elasticity correlates with the estimated diffusion restriction by MRI ADC measurements in rectal tumours. The relationship between ARFI and ADC measurement was linear in our study population.
OriginalsprogEngelsk
Publikationsdato9. jun. 2015
Antal sider1
StatusUdgivet - 9. jun. 2015
BegivenhedEuropean Society of Gastrointestinal Radiology: Annual Meeting - La Défense, Paris, Frankrig
Varighed: 9. jun. 201512. jun. 2015
Konferencens nummer: 26

Konference

KonferenceEuropean Society of Gastrointestinal Radiology
Nummer26
LokationLa Défense
LandFrankrig
ByParis
Periode09/06/201512/06/2015

Citer dette

Rafaelsen, S. R., Vagn-Hansen, C. A., Sørensen, T., Lindebjerg, J., Pløen, J., & Jakobsen, A. (2015). Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer. Poster session præsenteret på European Society of Gastrointestinal Radiology, Paris, Frankrig.
Rafaelsen, Søren Rafael ; Vagn-Hansen, Chris Aksel ; Sørensen, Torben ; Lindebjerg, Jan ; Pløen, John ; Jakobsen, Anders. / Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer. Poster session præsenteret på European Society of Gastrointestinal Radiology, Paris, Frankrig.1 s.
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abstract = "OBJECTIVE: The current literature has described the usefulness of elastography and diffusion weighted MRI in cancer patients, but to the best of our knowledge so far none of them have compared the two new methods. The tumour cell density is related to the MRI measured apparent diffusion weighted coefficient (ADC). The purpose of the present study was to compare quantitative elastography based on ultrasound shear wave measurements with MRI ADC. METHODS AND MATERIALS: We prospectively examined consecutive 52 patients with histopathological proven rectal cancer. The tumour elasticity was measured using the Acoustic Radiation Force Impulse (ARFI) to generate information on the mechanical properties of the tissue. The objective quantitative elastography shear wave velocity was blindly compared to the ADC measurements using a 1.5 Tesla MRI system. The study was approved by the local Clinical Ethics Committee. RESULTS: The mean tumour elasticity was 3.05 m/s (SD:0.79) and the mean ADC was 0.69 mm2/s (SD: 0.27). Elasticity was inversely strong correlated with ADC, r = -0.65 (Salkin scale). ARFI = 4.392 – 1.949 x ADC, R2 = 0.43, P < 000.1. Intercept = 4.392 (95{\%} CI:3.92 – 4.86), Slope = -1.949 (95{\%} CI: -1.31 - -2.59), P < 0.0001. CONCLUSION: Elasticity correlates with the estimated diffusion restriction by MRI ADC measurements in rectal tumours. The relationship between ARFI and ADC measurement was linear in our study population.",
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Rafaelsen, SR, Vagn-Hansen, CA, Sørensen, T, Lindebjerg, J, Pløen, J & Jakobsen, A 2015, 'Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer' European Society of Gastrointestinal Radiology, Paris, Frankrig, 09/06/2015 - 12/06/2015, .

Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer. / Rafaelsen, Søren Rafael; Vagn-Hansen, Chris Aksel; Sørensen, Torben; Lindebjerg, Jan; Pløen, John; Jakobsen, Anders.

2015. Poster session præsenteret på European Society of Gastrointestinal Radiology, Paris, Frankrig.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

TY - CONF

T1 - Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer

AU - Rafaelsen, Søren Rafael

AU - Vagn-Hansen, Chris Aksel

AU - Sørensen, Torben

AU - Lindebjerg, Jan

AU - Pløen, John

AU - Jakobsen, Anders

PY - 2015/6/9

Y1 - 2015/6/9

N2 - OBJECTIVE: The current literature has described the usefulness of elastography and diffusion weighted MRI in cancer patients, but to the best of our knowledge so far none of them have compared the two new methods. The tumour cell density is related to the MRI measured apparent diffusion weighted coefficient (ADC). The purpose of the present study was to compare quantitative elastography based on ultrasound shear wave measurements with MRI ADC. METHODS AND MATERIALS: We prospectively examined consecutive 52 patients with histopathological proven rectal cancer. The tumour elasticity was measured using the Acoustic Radiation Force Impulse (ARFI) to generate information on the mechanical properties of the tissue. The objective quantitative elastography shear wave velocity was blindly compared to the ADC measurements using a 1.5 Tesla MRI system. The study was approved by the local Clinical Ethics Committee. RESULTS: The mean tumour elasticity was 3.05 m/s (SD:0.79) and the mean ADC was 0.69 mm2/s (SD: 0.27). Elasticity was inversely strong correlated with ADC, r = -0.65 (Salkin scale). ARFI = 4.392 – 1.949 x ADC, R2 = 0.43, P < 000.1. Intercept = 4.392 (95% CI:3.92 – 4.86), Slope = -1.949 (95% CI: -1.31 - -2.59), P < 0.0001. CONCLUSION: Elasticity correlates with the estimated diffusion restriction by MRI ADC measurements in rectal tumours. The relationship between ARFI and ADC measurement was linear in our study population.

AB - OBJECTIVE: The current literature has described the usefulness of elastography and diffusion weighted MRI in cancer patients, but to the best of our knowledge so far none of them have compared the two new methods. The tumour cell density is related to the MRI measured apparent diffusion weighted coefficient (ADC). The purpose of the present study was to compare quantitative elastography based on ultrasound shear wave measurements with MRI ADC. METHODS AND MATERIALS: We prospectively examined consecutive 52 patients with histopathological proven rectal cancer. The tumour elasticity was measured using the Acoustic Radiation Force Impulse (ARFI) to generate information on the mechanical properties of the tissue. The objective quantitative elastography shear wave velocity was blindly compared to the ADC measurements using a 1.5 Tesla MRI system. The study was approved by the local Clinical Ethics Committee. RESULTS: The mean tumour elasticity was 3.05 m/s (SD:0.79) and the mean ADC was 0.69 mm2/s (SD: 0.27). Elasticity was inversely strong correlated with ADC, r = -0.65 (Salkin scale). ARFI = 4.392 – 1.949 x ADC, R2 = 0.43, P < 000.1. Intercept = 4.392 (95% CI:3.92 – 4.86), Slope = -1.949 (95% CI: -1.31 - -2.59), P < 0.0001. CONCLUSION: Elasticity correlates with the estimated diffusion restriction by MRI ADC measurements in rectal tumours. The relationship between ARFI and ADC measurement was linear in our study population.

M3 - Poster

ER -

Rafaelsen SR, Vagn-Hansen CA, Sørensen T, Lindebjerg J, Pløen J, Jakobsen A. Ultrasound elastography and diffusion weighted MRI in patients with rectal cancer. 2015. Poster session præsenteret på European Society of Gastrointestinal Radiology, Paris, Frankrig.