Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa

Magdy M D Mohammed*, Nabaweya A. Ibrahim, Fatma S. El-Sakhawy, Khaled M. Mohamed, Doaa A H Deabes

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly.

OriginalsprogEngelsk
TidsskriftNatural Product Research
Vol/bind30
Udgave nummer22
Sider (fra-til)2559-2566
ISSN1478-6419
DOI
StatusUdgivet - 2016

Fingeraftryk

Aegle
Alkaloids
MCF-7 Cells
Ether
Cell Line
Acids

Citer dette

Mohammed, M. M. D., Ibrahim, N. A., El-Sakhawy, F. S., Mohamed, K. M., & Deabes, D. A. H. (2016). Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa. Natural Product Research, 30(22), 2559-2566. https://doi.org/10.1080/14786419.2015.1126262
Mohammed, Magdy M D ; Ibrahim, Nabaweya A. ; El-Sakhawy, Fatma S. ; Mohamed, Khaled M. ; Deabes, Doaa A H. / Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa. I: Natural Product Research. 2016 ; Bind 30, Nr. 22. s. 2559-2566.
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title = "Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa",
abstract = "Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly.",
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author = "Mohammed, {Magdy M D} and Ibrahim, {Nabaweya A.} and El-Sakhawy, {Fatma S.} and Mohamed, {Khaled M.} and Deabes, {Doaa A H}",
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doi = "10.1080/14786419.2015.1126262",
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Mohammed, MMD, Ibrahim, NA, El-Sakhawy, FS, Mohamed, KM & Deabes, DAH 2016, 'Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa', Natural Product Research, bind 30, nr. 22, s. 2559-2566. https://doi.org/10.1080/14786419.2015.1126262

Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa. / Mohammed, Magdy M D; Ibrahim, Nabaweya A.; El-Sakhawy, Fatma S.; Mohamed, Khaled M.; Deabes, Doaa A H.

I: Natural Product Research, Bind 30, Nr. 22, 2016, s. 2559-2566.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa

AU - Mohammed, Magdy M D

AU - Ibrahim, Nabaweya A.

AU - El-Sakhawy, Fatma S.

AU - Mohamed, Khaled M.

AU - Deabes, Doaa A H

PY - 2016

Y1 - 2016

N2 - Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly.

AB - Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly.

KW - Aegle marmelos (Linn.) Correa

KW - cytotoxicity

KW - furoquinoline alkaloids

KW - rutaceae

KW - structure–activity relationship studies

U2 - 10.1080/14786419.2015.1126262

DO - 10.1080/14786419.2015.1126262

M3 - Journal article

VL - 30

SP - 2559

EP - 2566

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 22

ER -