Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3

linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients

Jiaoyang Yin, Ulla Vogel, Lars Ulrik Gerdes, Marianne Dybdahl, Lars Bolund, Bjørn Andersen Nexø

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.

    OriginalsprogEngelsk
    TidsskriftBiochemical Genetics
    Vol/bind41
    Udgave nummer1-2
    Sider (fra-til)27-37
    Antal sider11
    ISSN0006-2928
    StatusUdgivet - feb. 2003

    Fingeraftryk

    Linkage Disequilibrium
    Chromosomes
    linkage disequilibrium
    Polymorphism
    disequilibrium
    single nucleotide polymorphism
    carcinoma
    Single Nucleotide Polymorphism
    chromosome
    polymorphism
    Nucleotides
    Genes
    Cells
    chromosomes
    gene
    Association reactions
    Biomarkers
    cells
    confidence interval
    repair

    Citer dette

    Yin, Jiaoyang ; Vogel, Ulla ; Gerdes, Lars Ulrik ; Dybdahl, Marianne ; Bolund, Lars ; Nexø, Bjørn Andersen. / Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3 : linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients. I: Biochemical Genetics. 2003 ; Bind 41, Nr. 1-2. s. 27-37.
    @article{5f7c1aef76324c7591922aca907be3c6,
    title = "Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients",
    abstract = "The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95{\%} Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.",
    keywords = "Adult, Carcinoma, Basal Cell, Chromosomes, Human, Pair 19, DNA Helicases, DNA Mutational Analysis, DNA Repair, DNA-Binding Proteins, Denmark, Endonucleases, Genetic Predisposition to Disease, Humans, Linkage Disequilibrium, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Proteins, Psoriasis, Skin Neoplasms, Transcription Factors, Xeroderma Pigmentosum Group D Protein",
    author = "Jiaoyang Yin and Ulla Vogel and Gerdes, {Lars Ulrik} and Marianne Dybdahl and Lars Bolund and Nex{\o}, {Bj{\o}rn Andersen}",
    year = "2003",
    month = "2",
    language = "English",
    volume = "41",
    pages = "27--37",
    journal = "Biochemical Genetics",
    issn = "0006-2928",
    publisher = "Springer",
    number = "1-2",

    }

    Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3 : linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients. / Yin, Jiaoyang; Vogel, Ulla; Gerdes, Lars Ulrik; Dybdahl, Marianne; Bolund, Lars; Nexø, Bjørn Andersen.

    I: Biochemical Genetics, Bind 41, Nr. 1-2, 02.2003, s. 27-37.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3

    T2 - linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients

    AU - Yin, Jiaoyang

    AU - Vogel, Ulla

    AU - Gerdes, Lars Ulrik

    AU - Dybdahl, Marianne

    AU - Bolund, Lars

    AU - Nexø, Bjørn Andersen

    PY - 2003/2

    Y1 - 2003/2

    N2 - The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.

    AB - The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.

    KW - Adult

    KW - Carcinoma, Basal Cell

    KW - Chromosomes, Human, Pair 19

    KW - DNA Helicases

    KW - DNA Mutational Analysis

    KW - DNA Repair

    KW - DNA-Binding Proteins

    KW - Denmark

    KW - Endonucleases

    KW - Genetic Predisposition to Disease

    KW - Humans

    KW - Linkage Disequilibrium

    KW - Polymorphism, Restriction Fragment Length

    KW - Polymorphism, Single Nucleotide

    KW - Proteins

    KW - Psoriasis

    KW - Skin Neoplasms

    KW - Transcription Factors

    KW - Xeroderma Pigmentosum Group D Protein

    M3 - Journal article

    VL - 41

    SP - 27

    EP - 37

    JO - Biochemical Genetics

    JF - Biochemical Genetics

    SN - 0006-2928

    IS - 1-2

    ER -