Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy

Peter Aaby, T G Jensen, H L Hansen, H Kristiansen, J Thårup, A Poulsen, Morten Sodemann, M Jakobsen, K Knudsen, M Clotilde da Silva

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.
OriginalsprogEngelsk
TidsskriftLancet
Vol/bind2
Udgave nummer8615
Sider (fra-til)809-11
Antal sider3
ISSN0140-6736
StatusUdgivet - 1988

Fingeraftryk

Guinea-Bissau
Measles

Citer dette

Aaby, P., Jensen, T. G., Hansen, H. L., Kristiansen, H., Thårup, J., Poulsen, A., ... Clotilde da Silva, M. (1988). Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. Lancet, 2(8615), 809-11.
Aaby, Peter ; Jensen, T G ; Hansen, H L ; Kristiansen, H ; Thårup, J ; Poulsen, A ; Sodemann, Morten ; Jakobsen, M ; Knudsen, K ; Clotilde da Silva, M. / Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau : protective efficacy. I: Lancet. 1988 ; Bind 2, Nr. 8615. s. 809-11.
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title = "Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy",
abstract = "In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.",
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Aaby, P, Jensen, TG, Hansen, HL, Kristiansen, H, Thårup, J, Poulsen, A, Sodemann, M, Jakobsen, M, Knudsen, K & Clotilde da Silva, M 1988, 'Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy', Lancet, bind 2, nr. 8615, s. 809-11.

Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau : protective efficacy. / Aaby, Peter; Jensen, T G; Hansen, H L; Kristiansen, H; Thårup, J; Poulsen, A; Sodemann, Morten ; Jakobsen, M; Knudsen, K; Clotilde da Silva, M.

I: Lancet, Bind 2, Nr. 8615, 1988, s. 809-11.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau

T2 - protective efficacy

AU - Aaby, Peter

AU - Jensen, T G

AU - Hansen, H L

AU - Kristiansen, H

AU - Thårup, J

AU - Poulsen, A

AU - Sodemann, Morten

AU - Jakobsen, M

AU - Knudsen, K

AU - Clotilde da Silva, M

PY - 1988

Y1 - 1988

N2 - In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.

AB - In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.

KW - Age Factors

KW - Clinical Trials as Topic

KW - Drug Evaluation

KW - Female

KW - Guinea-Bissau

KW - Humans

KW - Immunization Schedule

KW - Infant

KW - Measles

KW - Measles Vaccine

KW - Random Allocation

KW - Urban Population

KW - Vaccination

M3 - Journal article

C2 - 2902263

VL - 2

SP - 809

EP - 811

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 8615

ER -

Aaby P, Jensen TG, Hansen HL, Kristiansen H, Thårup J, Poulsen A et al. Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. Lancet. 1988;2(8615):809-11.