Abstrakt
BACKGROUND: There is no consensus regarding chemotherapy to patients with advanced NSCLC (ANSCLC) and performance status (PS) 2. Using data from a national multicenter study comparing two third-generation carboplatin-based regimens in ANSCLC patients, we evaluated the outcome of PS 2 patients.
PATIENTS AND METHODS: The 123 PS 2 patients were compared to 309 PS 0/1 patients regarding survival, quality of life (QOL) and treatment toxicity.
RESULTS: PS 2 patients had lower haemoglobin, lower global QOL and more pain, nausea/vomiting and dyspnea at inclusion. 68% of PS 2 patients received three chemotherapy courses vs. 85% in the PS 0/1 group (P<0.01). Median and 1-year survival were lower in the PS 2 group, 4.5 vs. 8.9 months and 10% vs. 37% (P<.01). More PS 2 patients needed blood transfusions (P=0.03) and hospitalization (P<0.01). In contrast, PS 2 patients had better relief of pain and dyspnea, and tended to a better global QOL and did not experience more leucopoenia, infections or bleeding.
CONCLUSIONS: Despite shorter survival, treatment toxicity was acceptable and PS 2 patients achieved better improvement of pain and dyspnea and tended to better global QOL when compared to PS 0/1 patients.
Originalsprog | Engelsk |
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Tidsskrift | Lung cancer (Amsterdam, Netherlands) |
Vol/bind | 62 |
Udgave nummer | 2 |
Sider (fra-til) | 253-260 |
ISSN | 0169-5002 |
DOI | |
Status | Udgivet - nov. 2008 |
Udgivet eksternt | Ja |
Emneord
- Antineoplastic Combined Chemotherapy Protocols
- Carboplatin
- Carcinoma, Non-Small-Cell Lung
- Deoxycytidine
- Humans
- Kaplan-Meier Estimate
- Karnofsky Performance Status
- Lung Neoplasms
- Quality of Life
- Treatment Outcome
- Vinblastine