Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy

Nina Helbekkmo*, Ulf Aasebø, Stein H Sundstrøm, Christian von Plessen, Paal Fr Brunsvig, Roy M Bremnes, Norwegian Lung Cancer Study Group

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

BACKGROUND: There is no consensus regarding chemotherapy to patients with advanced NSCLC (ANSCLC) and performance status (PS) 2. Using data from a national multicenter study comparing two third-generation carboplatin-based regimens in ANSCLC patients, we evaluated the outcome of PS 2 patients.

PATIENTS AND METHODS: The 123 PS 2 patients were compared to 309 PS 0/1 patients regarding survival, quality of life (QOL) and treatment toxicity.

RESULTS: PS 2 patients had lower haemoglobin, lower global QOL and more pain, nausea/vomiting and dyspnea at inclusion. 68% of PS 2 patients received three chemotherapy courses vs. 85% in the PS 0/1 group (P<0.01). Median and 1-year survival were lower in the PS 2 group, 4.5 vs. 8.9 months and 10% vs. 37% (P<.01). More PS 2 patients needed blood transfusions (P=0.03) and hospitalization (P<0.01). In contrast, PS 2 patients had better relief of pain and dyspnea, and tended to a better global QOL and did not experience more leucopoenia, infections or bleeding.

CONCLUSIONS: Despite shorter survival, treatment toxicity was acceptable and PS 2 patients achieved better improvement of pain and dyspnea and tended to better global QOL when compared to PS 0/1 patients.

OriginalsprogEngelsk
TidsskriftLung cancer (Amsterdam, Netherlands)
Vol/bind62
Udgave nummer2
Sider (fra-til)253-260
ISSN0169-5002
DOI
StatusUdgivet - nov. 2008
Udgivet eksterntJa

Emneord

  • Antineoplastic Combined Chemotherapy Protocols
  • Carboplatin
  • Carcinoma, Non-Small-Cell Lung
  • Deoxycytidine
  • Humans
  • Kaplan-Meier Estimate
  • Karnofsky Performance Status
  • Lung Neoplasms
  • Quality of Life
  • Treatment Outcome
  • Vinblastine

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