Abstract
The purpose of this study was to examine the transfer rate of SARS-CoV-2 IgG antibodies in pregnancy and newborns. Two Danish labor wards screened all women for SARS-CoV-2 by PCR upon arrival. Women (n = 99) with a SARS-CoV-2 PCR–positive nasopharyngeal (NP) swab or with a household member with a positive swab at labor or any time during pregnancy, or COVID-19 symptoms upon admission (November 2020 through August 2021), were included. Mother and infant were tested by NP swabs at delivery, and maternal and infant (umbilical cord) venous blood samples were collected. We obtained clinical information including previous PCR test results from the medical records. SARS-Cov-2 IgM and quantified IgG antibodies were measured by enzyme-linked immunosorbent assay and transfer ratios of IgG. We detected IgG antibodies in 73 women and 65 cord blood sera and found a strong correlation between SARS-CoV-2 IgG concentrations in maternal and umbilical cord sera (r = 0.9; p < 0.05). Transfer ratio was > 1.0 in 51 out of 73 (69%) infants and > 1.5 in 26 (35%). We found that transfer was proportional to time from a positive SARS-CoV-2 PCR NP swab to delivery (r = 0.5; p < 0.05). Transfer ratios of SARS-CoV-2 antibodies were associated with time from infection to delivery with transfer ratios of more than 1.0 in the majority of seropositive mother-infant dyads.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Clinical Microbiology & Infectious Diseases |
| Vol/bind | 42 |
| Udgave nummer | 3 |
| Sider (fra-til) | 277-285 |
| ISSN | 0934-9723 |
| DOI | |
| Status | Udgivet - mar. 2023 |
Bibliografisk note
Funding Information:The project received funding from Novo Nordisk Fonden (NNF20SA0062875). The funder played no role in the conduction of research or writing of the manuscript.
Funding Information:
The authors would like to thank all the participants, the midwives, and the laboratory technicians at Aarhus University Hospital and Lillebaelt Hospital and Novo Nordisk Fonden. A special thank you to Lene Toft Nielsen, Lone Pødenphant, Camilla Andersen, and Lene Yding.