Transient Receptor Potential Canonical Type 3 Channels - Their Evolving Role in Hypertension and Its Related Complications

Peijian Wang, Daoyan Liu, Martin Tepel, Zhiming Zhu

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Abstrakt

Recent studies indicate that transient receptor potential canonical type 3 (TRPC3) channels contribute to the regulation of blood pressure and vascular and renal function. Several studies show that TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events. In this review, we summarize the role of TRPC3 channels in the cardiovascular system, and we focus on their pathophysiogical role in hypertension and related target organ damages. We provide new insight into the involvement of TRPC3 channels in the development of hypertension and its related complications.

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Pharmacology
Vol/bind61
Udgave nummer6
Sider (fra-til)455-460
ISSN0160-2446
DOI
StatusUdgivet - jun. 2013

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