Transgenic engineering of male-specific muscular hypertrophy

D. Pirottin, L. Grobet, A. Adamantidis, F. Farnir, C. Herens, Henrik Daa Schrøder, M. Georges

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Abstrakt

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows.

OriginalsprogEngelsk
TidsskriftProceedings of the National Academy of Science of the United States of America
Vol/bind102
Udgave nummer18
Sider (fra-til)6413-8
Antal sider6
ISSN0027-8424
DOI
StatusUdgivet - 2005

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