Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi; Peter Aaby; Shabaana Abdul Khader; Luis B. Barreiro; Siroon Bekkering; Triantafyllos Chavakis; Reinout van Crevel; Nigel Curtis; Andrew R. DiNardo; Jorge Dominguez-Andres; Raphael Duivenwoorden; Stephanie Fanucchi; Zahi Fayad; Elaine Fuchs; Melanie Hamon; Kate L. Jeffrey; Nargis Khan; Leo A.B. Joosten; Eva Kaufmann; Eicke Latz; Giuseppe Matarese; Jos W.M. van der Meer; Musa Mhlanga; Simone J.C.F.M. Moorlag; Willem J.M. Mulder; Shruti Naik; Boris Novakovic; Luke O’Neill; Jordi Ochando; Keiko Ozato; Niels P. Riksen; Robert Sauerwein; Edward R. Sherwood; Andreas Schlitzer; Joachim L. Schultze; Michael H. Sieweke; Christine Stabell Benn; Henk Stunnenberg; Joseph Sun; Frank L. van de Veerdonk; Sebastian Weis; David L. Williams; Ramnik Xavier; Mihai G. Netea

doi:10.1038/s41590-020-00845-6

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi^*, Peter Aaby, Shabaana Abdul Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R. DiNardo, Jorge Dominguez-Andres, Raphael Duivenwoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L. Jeffrey, Nargis Khan, Leo A.B. Joosten, Eva Kaufmann, Eicke LatzGiuseppe Matarese, Jos W.M. van der Meer, Musa Mhlanga, Simone J.C.F.M. Moorlag, Willem J.M. Mulder, Shruti Naik, Boris Novakovic, Luke O’Neill, Jordi Ochando, Keiko Ozato, Niels P. Riksen, Robert Sauerwein, Edward R. Sherwood, Andreas Schlitzer, Joachim L. Schultze, Michael H. Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L. van de Veerdonk, Sebastian Weis, David L. Williams, Ramnik Xavier, Mihai G. Netea

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

Abstract

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

Originalsprog	Engelsk
Tidsskrift	Nature Immunology
Vol/bind	22
Udgave nummer	1
Sider (fra-til)	2–6
ISSN	1529-2908
DOI	https://doi.org/10.1038/s41590-020-00845-6
Status	Udgivet - jan. 2021

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Divangahi, M., Aaby, P., Khader, S. A., Barreiro, L. B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A. R., Dominguez-Andres, J., Duivenwoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K. L., Khan, N., Joosten, L. A. B., Kaufmann, E., ... Netea, M. G. (2021). Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nature Immunology, 22(1), 2–6. https://doi.org/10.1038/s41590-020-00845-6

@article{13d37e05971548efa42d897c3bc0b2f1,

title = "Trained immunity, tolerance, priming and differentiation: distinct immunological processes",

abstract = "The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.",

author = "Maziar Divangahi and Peter Aaby and Khader, {Shabaana Abdul} and Barreiro, {Luis B.} and Siroon Bekkering and Triantafyllos Chavakis and {van Crevel}, Reinout and Nigel Curtis and DiNardo, {Andrew R.} and Jorge Dominguez-Andres and Raphael Duivenwoorden and Stephanie Fanucchi and Zahi Fayad and Elaine Fuchs and Melanie Hamon and Jeffrey, {Kate L.} and Nargis Khan and Joosten, {Leo A.B.} and Eva Kaufmann and Eicke Latz and Giuseppe Matarese and {van der Meer}, {Jos W.M.} and Musa Mhlanga and Moorlag, {Simone J.C.F.M.} and Mulder, {Willem J.M.} and Shruti Naik and Boris Novakovic and Luke O{\textquoteright}Neill and Jordi Ochando and Keiko Ozato and Riksen, {Niels P.} and Robert Sauerwein and Sherwood, {Edward R.} and Andreas Schlitzer and Schultze, {Joachim L.} and Sieweke, {Michael H.} and Benn, {Christine Stabell} and Henk Stunnenberg and Joseph Sun and {van de Veerdonk}, {Frank L.} and Sebastian Weis and Williams, {David L.} and Ramnik Xavier and Netea, {Mihai G.}",

year = "2021",

month = jan,

doi = "10.1038/s41590-020-00845-6",

language = "English",

volume = "22",

pages = "2–6",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

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Divangahi, M, Aaby, P, Khader, SA, Barreiro, LB, Bekkering, S, Chavakis, T, van Crevel, R, Curtis, N, DiNardo, AR, Dominguez-Andres, J, Duivenwoorden, R, Fanucchi, S, Fayad, Z, Fuchs, E, Hamon, M, Jeffrey, KL, Khan, N, Joosten, LAB, Kaufmann, E, Latz, E, Matarese, G, van der Meer, JWM, Mhlanga, M, Moorlag, SJCFM, Mulder, WJM, Naik, S, Novakovic, B, O’Neill, L, Ochando, J, Ozato, K, Riksen, NP, Sauerwein, R, Sherwood, ER, Schlitzer, A, Schultze, JL, Sieweke, MH, Benn, CS, Stunnenberg, H, Sun, J, van de Veerdonk, FL, Weis, S, Williams, DL, Xavier, R & Netea, MG 2021, 'Trained immunity, tolerance, priming and differentiation: distinct immunological processes', Nature Immunology, bind 22, nr. 1, s. 2–6. https://doi.org/10.1038/s41590-020-00845-6

TY - JOUR

T1 - Trained immunity, tolerance, priming and differentiation

T2 - distinct immunological processes

AU - Divangahi, Maziar

AU - Aaby, Peter

AU - Khader, Shabaana Abdul

AU - Barreiro, Luis B.

AU - Bekkering, Siroon

AU - Chavakis, Triantafyllos

AU - van Crevel, Reinout

AU - Curtis, Nigel

AU - DiNardo, Andrew R.

AU - Dominguez-Andres, Jorge

AU - Duivenwoorden, Raphael

AU - Fanucchi, Stephanie

AU - Fayad, Zahi

AU - Fuchs, Elaine

AU - Hamon, Melanie

AU - Jeffrey, Kate L.

AU - Khan, Nargis

AU - Joosten, Leo A.B.

AU - Kaufmann, Eva

AU - Latz, Eicke

AU - Matarese, Giuseppe

AU - van der Meer, Jos W.M.

AU - Mhlanga, Musa

AU - Moorlag, Simone J.C.F.M.

AU - Mulder, Willem J.M.

AU - Naik, Shruti

AU - Novakovic, Boris

AU - O’Neill, Luke

AU - Ochando, Jordi

AU - Ozato, Keiko

AU - Riksen, Niels P.

AU - Sauerwein, Robert

AU - Sherwood, Edward R.

AU - Schlitzer, Andreas

AU - Schultze, Joachim L.

AU - Sieweke, Michael H.

AU - Benn, Christine Stabell

AU - Stunnenberg, Henk

AU - Sun, Joseph

AU - van de Veerdonk, Frank L.

AU - Weis, Sebastian

AU - Williams, David L.

AU - Xavier, Ramnik

AU - Netea, Mihai G.

PY - 2021/1

Y1 - 2021/1

N2 - The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

AB - The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

UR - https://doi.org/10.1038/s41590-021-00960-y

U2 - 10.1038/s41590-020-00845-6

DO - 10.1038/s41590-020-00845-6

M3 - Comment/debate

C2 - 33293712

AN - SCOPUS:85097285095

SN - 1529-2908

VL - 22

SP - 2

EP - 6

JO - Nature Immunology

JF - Nature Immunology

IS - 1

ER -

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Abstract

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