Tracking of bone mass from childhood to puberty

a 7-year follow-up. The CHAMPS study DK

M. S. Rønne*, M. Heidemann, A. Schou, J. O. Laursen, A. B. Bojesen, L. Lylloff, S. Husby, N. Wedderkopp, C. Mølgaard

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Summary: Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health. Introduction: Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence. Methods: A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years. Results: Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80–0.84). Conclusions: Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.

OriginalsprogEngelsk
TidsskriftOsteoporosis International
Vol/bind29
Udgave nummer8
Sider (fra-til)1843–1852
ISSN0937-941X
DOI
StatusUdgivet - aug. 2018

Fingeraftryk

Bone Density
Photon Absorptiometry
Luteinizing Hormone
Longitudinal Studies
Health
Self-Assessment
Child Health

Citer dette

@article{ee78dce5604240938c4ff043cc090147,
title = "Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK",
abstract = "Summary: Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health. Introduction: Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence. Methods: A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years. Results: Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80{\%} of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80–0.84). Conclusions: Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.",
keywords = "Bone mass, Dual-energy X-ray absorptiometry, Longitudinal, Puberty, Tracking",
author = "R{\o}nne, {M. S.} and M. Heidemann and A. Schou and Laursen, {J. O.} and Bojesen, {A. B.} and L. Lylloff and S. Husby and N. Wedderkopp and C. M{\o}lgaard",
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month = "8",
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language = "English",
volume = "29",
pages = "1843–1852",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer",
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Tracking of bone mass from childhood to puberty : a 7-year follow-up. The CHAMPS study DK. / Rønne, M. S.; Heidemann, M.; Schou, A.; Laursen, J. O.; Bojesen, A. B.; Lylloff, L.; Husby, S.; Wedderkopp, N.; Mølgaard, C.

I: Osteoporosis International, Bind 29, Nr. 8, 08.2018, s. 1843–1852.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Tracking of bone mass from childhood to puberty

T2 - a 7-year follow-up. The CHAMPS study DK

AU - Rønne, M. S.

AU - Heidemann, M.

AU - Schou, A.

AU - Laursen, J. O.

AU - Bojesen, A. B.

AU - Lylloff, L.

AU - Husby, S.

AU - Wedderkopp, N.

AU - Mølgaard, C.

PY - 2018/8

Y1 - 2018/8

N2 - Summary: Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health. Introduction: Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence. Methods: A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years. Results: Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80–0.84). Conclusions: Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.

AB - Summary: Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health. Introduction: Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence. Methods: A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years. Results: Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80–0.84). Conclusions: Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.

KW - Bone mass

KW - Dual-energy X-ray absorptiometry

KW - Longitudinal

KW - Puberty

KW - Tracking

U2 - 10.1007/s00198-018-4556-z

DO - 10.1007/s00198-018-4556-z

M3 - Journal article

VL - 29

SP - 1843

EP - 1852

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 8

ER -