Towards protocell embedded replication of nucleic acids

Philipp M. G. Löffler, Rafal Wieczorek, Michael Chr. Wamberg, Mark Dörr, Pernille Lykke Pedersen, Carsten Svaneborg, Harold Fellermann, Joseph B. Edson, Jonathan Cape, Hans-Joachim Ziock, James M. Boncella, Steen Rasmussen, Pierre-Alain Monnard

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The construction of a self-reproducing chemical system possessing simplified capabilities of a living cell is a major scientific challenge and a milestone for Artificial Life research. Minimal living physicochemical systems should encompass “information”, “energy transformation” and “co-localization” in a mutually interdependent manner. A fundamental design strategy to achieve such minimal living system was outlined in Rasmussen et al. (2003, 2004), and to reach that goal we have defined a chemical dependency between each of the three component subsystems. The replication of the information molecules must depend on the formation of the container, while the formation of the container must depend on the work of the metabolism, likewise, the work of the metabolism must depend on the replication of the information molecules. This work focuses of the information replication processes, where we have recently developed a template-directed synthesis of oligonucleotides by non-enzymatic ligation (Cape et al., 2012), which is connected to the growth of the container by the action of a Ruthenium catalyst.
TitelArtificial Life 13: Proceedings of the Thirteenth International Conference on the Synthesis and Simulation of Living Systems
RedaktørerChristoph Adami, David M. Bryson, Charles Ofria, Robert T. Pennock
Antal sider2
ForlagMIT Press
StatusUdgivet - 2012


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