Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium

Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A van den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne Ewertz, Roni T Falk, Mia M Gaudet, George Gkiokas, Laurel A Habel, Ann W Hsing, Kenneth Johnson, Laurence N Kolonel, Carlo La Vecchia, Elsebeth Lynge, Jay H Lubin, Valerie A McCormackEva Negri, Hakan Olsson, Dominick Parisi, Eleni Th Petridou, Elio Riboli, Howard D Sesso, Anthony Swerdlow, David B Thomas, Walter C Willett, Louise A Brinton

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.

Fingeraftryk

Male Breast Neoplasms
Alcohols
Smoking
Confidence Intervals
Alcohol Drinking
Odds Ratio
Tobacco Use
Meta-Analysis
Body Mass Index
Cohort Studies
Logistic Models

Citer dette

Cook, Michael B ; Guenel, Pascal ; Gapstur, Susan M ; van den Brandt, Piet A ; Michels, Karin B ; Casagrande, John T ; Cooke, Rosie ; Van Den Eeden, Stephen K ; Ewertz, Marianne ; Falk, Roni T ; Gaudet, Mia M ; Gkiokas, George ; Habel, Laurel A ; Hsing, Ann W ; Johnson, Kenneth ; Kolonel, Laurence N ; La Vecchia, Carlo ; Lynge, Elsebeth ; Lubin, Jay H ; McCormack, Valerie A ; Negri, Eva ; Olsson, Hakan ; Parisi, Dominick ; Petridou, Eleni Th ; Riboli, Elio ; Sesso, Howard D ; Swerdlow, Anthony ; Thomas, David B ; Willett, Walter C ; Brinton, Louise A. / Tobacco and Alcohol in Relation to Male Breast Cancer : An Analysis of the Male Breast Cancer Pooling Project Consortium. I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015.
@article{fb18c3bdf83b4c42bf146fd44112a711,
title = "Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium",
abstract = "Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95{\%} confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95{\%}CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95{\%}CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.",
author = "Cook, {Michael B} and Pascal Guenel and Gapstur, {Susan M} and {van den Brandt}, {Piet A} and Michels, {Karin B} and Casagrande, {John T} and Rosie Cooke and {Van Den Eeden}, {Stephen K} and Marianne Ewertz and Falk, {Roni T} and Gaudet, {Mia M} and George Gkiokas and Habel, {Laurel A} and Hsing, {Ann W} and Kenneth Johnson and Kolonel, {Laurence N} and {La Vecchia}, Carlo and Elsebeth Lynge and Lubin, {Jay H} and McCormack, {Valerie A} and Eva Negri and Hakan Olsson and Dominick Parisi and Petridou, {Eleni Th} and Elio Riboli and Sesso, {Howard D} and Anthony Swerdlow and Thomas, {David B} and Willett, {Walter C} and Brinton, {Louise A}",
note = "Copyright {\circledC} 2014, American Association for Cancer Research.",
year = "2015",
doi = "10.1158/1055-9965.EPI-14-1009",
language = "English",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",

}

Cook, MB, Guenel, P, Gapstur, SM, van den Brandt, PA, Michels, KB, Casagrande, JT, Cooke, R, Van Den Eeden, SK, Ewertz, M, Falk, RT, Gaudet, MM, Gkiokas, G, Habel, LA, Hsing, AW, Johnson, K, Kolonel, LN, La Vecchia, C, Lynge, E, Lubin, JH, McCormack, VA, Negri, E, Olsson, H, Parisi, D, Petridou, ET, Riboli, E, Sesso, HD, Swerdlow, A, Thomas, DB, Willett, WC & Brinton, LA 2015, 'Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. https://doi.org/10.1158/1055-9965.EPI-14-1009

Tobacco and Alcohol in Relation to Male Breast Cancer : An Analysis of the Male Breast Cancer Pooling Project Consortium. / Cook, Michael B; Guenel, Pascal; Gapstur, Susan M; van den Brandt, Piet A; Michels, Karin B; Casagrande, John T; Cooke, Rosie; Van Den Eeden, Stephen K; Ewertz, Marianne; Falk, Roni T; Gaudet, Mia M; Gkiokas, George; Habel, Laurel A; Hsing, Ann W; Johnson, Kenneth; Kolonel, Laurence N; La Vecchia, Carlo; Lynge, Elsebeth; Lubin, Jay H; McCormack, Valerie A; Negri, Eva; Olsson, Hakan; Parisi, Dominick; Petridou, Eleni Th; Riboli, Elio; Sesso, Howard D; Swerdlow, Anthony; Thomas, David B; Willett, Walter C; Brinton, Louise A.

I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Tobacco and Alcohol in Relation to Male Breast Cancer

T2 - An Analysis of the Male Breast Cancer Pooling Project Consortium

AU - Cook, Michael B

AU - Guenel, Pascal

AU - Gapstur, Susan M

AU - van den Brandt, Piet A

AU - Michels, Karin B

AU - Casagrande, John T

AU - Cooke, Rosie

AU - Van Den Eeden, Stephen K

AU - Ewertz, Marianne

AU - Falk, Roni T

AU - Gaudet, Mia M

AU - Gkiokas, George

AU - Habel, Laurel A

AU - Hsing, Ann W

AU - Johnson, Kenneth

AU - Kolonel, Laurence N

AU - La Vecchia, Carlo

AU - Lynge, Elsebeth

AU - Lubin, Jay H

AU - McCormack, Valerie A

AU - Negri, Eva

AU - Olsson, Hakan

AU - Parisi, Dominick

AU - Petridou, Eleni Th

AU - Riboli, Elio

AU - Sesso, Howard D

AU - Swerdlow, Anthony

AU - Thomas, David B

AU - Willett, Walter C

AU - Brinton, Louise A

N1 - Copyright © 2014, American Association for Cancer Research.

PY - 2015

Y1 - 2015

N2 - Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.

AB - Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.

U2 - 10.1158/1055-9965.EPI-14-1009

DO - 10.1158/1055-9965.EPI-14-1009

M3 - Journal article

C2 - 25515550

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

ER -